myctu-Rv3569c
Mycobacterium tuberculosis and Mycobacterium bovis Rv3569c 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase bphD BPHD HSAD HsaD
Comment
(2-hydroxy-6-phenylhexa-2,4-dienoic acid hydrolase) recommended name 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase. There are more than 1000 strains. Other Uniprot entries and list of strains can be found with the link: Other strains. Cholesterol metabolism contributes to the survival of M.tuberculosis in the host by helping the bacterial multiplication during earlier stages of infection and to the dissemination of the pathogen in the host.
Relationship
Family : Carbon-carbon_bond_hydrolase
Block : X
Position in NCBI Life Tree : Mycobacterium tuberculosis
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Bacteria N E > Terrabacteria group N E > Actinobacteria [phylum] N E > Actinobacteria [class] N E > Corynebacteriales N E > Mycobacteriaceae N E > Mycobacterium N E > Mycobacterium tuberculosis complex N E > Mycobacterium tuberculosis N EMolecular evidence
Sequence
Peptide
MTATEELTFE STSRFAEVDV DGPLKLHYHE AGVGNDQTVV LLHGGGPGAA SWTNFSRNIA VLARHFHVLA VDQPGYGHSD KRAEHGQFNR YAAMALKGLF DQLGLGRVPL VGNSLGGGTA VRFALDYPAR AGRLVLMGPG GLSINLFAPD PTEGVKRLSK FSVAPTRENL EAFLRVMVYD KNLITPELVD QRFALASTPE SLTATRAMGK SFAGADFEAG MMWREVYRLR QPVLLIWGRE DRVNPLDGAL VALKTIPRAQ LHVFGQCGHW VQVEKFDEFN KLTIEFLGGG R
References (13)
| Title : Direct capture, inhibition and crystal structure of HsaD (Rv3569c) from M. tuberculosis - Barelier_2022_FEBS.J__ |
| Author(s) : Barelier S , Avellan R , Gnawali GR , Fourquet P , Roig-Zamboni V , Poncin I , Point V , Bourne Y , Audebert S , Camoin L , Spilling CD , Canaan S , Cavalier JF , Sulzenbacher G |
| Ref : Febs J , : , 2022 |
| Abstract : |
| PubMedSearch : Barelier_2022_FEBS.J__ |
| PubMedID: 36197115 |
| Gene_locus related to this paper: myctu-Rv3569c |
| Title : Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach - Ryan_2017_Br.J.Pharmacol_174_2209 |
| Author(s) : Ryan A , Polycarpou E , Lack NA , Evangelopoulos D , Sieg C , Halman A , Bhakta S , Eleftheriadou O , McHugh TD , Keany S , Lowe ED , Ballet R , Abuhammad A , Jacobs WR, Jr. , Ciulli A , Sim E |
| Ref : British Journal of Pharmacology , 174 :2209 , 2017 |
| Abstract : |
| PubMedSearch : Ryan_2017_Br.J.Pharmacol_174_2209 |
| PubMedID: 28380256 |
| Gene_locus related to this paper: myctu-Rv3569c |
| Title : Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis - Nguyen_2017_Sci.Rep_7_11751 |
| Author(s) : Nguyen PC , Delorme V , Benarouche A , Martin BP , Paudel R , Gnawali GR , Madani A , Puppo R , Landry V , Kremer L , Brodin P , Spilling CD , Cavalier JF , Canaan S |
| Ref : Sci Rep , 7 :11751 , 2017 |
| Abstract : |
| PubMedSearch : Nguyen_2017_Sci.Rep_7_11751 |
| PubMedID: 28924204 |
| Gene_locus related to this paper: mycle-ML2603 , myctu-a85a , myctu-a85c , myctu-Rv1399c , myctu-Rv2970c , myctu-Rv3569c , myctu-yt28 |
| Title : Characterization of a carbon-carbon hydrolase from Mycobacterium tuberculosis involved in cholesterol metabolism - Lack_2010_J.Biol.Chem_285_434 |
| Author(s) : Lack NA , Yam KC , Lowe ED , Horsman GP , Owen RL , Sim E , Eltis LD |
| Ref : Journal of Biological Chemistry , 285 :434 , 2010 |
| Abstract : |
| PubMedSearch : Lack_2010_J.Biol.Chem_285_434 |
| PubMedID: 19875455 |
| Gene_locus related to this paper: myctu-Rv3569c |
| Title : Structure of HsaD, a steroid-degrading hydrolase, from Mycobacterium tuberculosis - Lack_2008_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_64_2 |
| Author(s) : Lack N , Lowe ED , Liu J , Eltis LD , Noble ME , Sim E , Westwood IM |
| Ref : Acta Crystallographica Sect F Struct Biol Cryst Commun , 64 :2 , 2008 |
| Abstract : |
| PubMedSearch : Lack_2008_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_64_2 |
| PubMedID: 18097091 |
| Gene_locus related to this paper: myctu-Rv3569c |
| Title : A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis - Kendall_2007_Mol.Microbiol_65_684 |
| Author(s) : Kendall SL , Withers M , Soffair CN , Moreland NJ , Gurcha S , Sidders B , Frita R , Ten Bokum A , Besra GS , Lott JS , Stoker NG |
| Ref : Molecular Microbiology , 65 :684 , 2007 |
| Abstract : |
| PubMedSearch : Kendall_2007_Mol.Microbiol_65_684 |
| PubMedID: 17635188 |
| Gene_locus related to this paper: myctu-Rv3569c |
| Title : A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages - Van der Geize_2007_Proc.Natl.Acad.Sci.U.S.A_104_1947 |
| Author(s) : Van der Geize R , Yam K , Heuser T , Wilbrink MH , Hara H , Anderton MC , Sim E , Dijkhuizen L , Davies JE , Mohn WW , Eltis LD |
| Ref : Proc Natl Acad Sci U S A , 104 :1947 , 2007 |
| Abstract : |
| PubMedSearch : Van der Geize_2007_Proc.Natl.Acad.Sci.U.S.A_104_1947 |
| PubMedID: 17264217 |
| Gene_locus related to this paper: myctu-Rv3569c |