aedae-q17b28

Aedes aegypti (Yellowfever mosquito) alpha-esterase CCEae6a

Comment

Bioassays on Ae. aegypti larvae from Thailand detected temephos resistance ratios ranging from 3.5 fold in Chiang Mai to nearly 10 fold in Nakhon Sawan (NS) province. CCEae3a, was upregulated more than 60 fold in the NS population compared to the susceptible population. A similar amplification occurs in other major arbovirus vector in the Asian Tiger Mosquito Aedes albopictus. The few mutaions found originally in the amplified allele do not seem to participate in resistance CCEae6a also amplified

Relationship

Family : Carb_B_Arthropoda

Block : C

Position in NCBI Life Tree : Aedes aegypti

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Protostomia N E > Ecdysozoa N E > Panarthropoda N E > Arthropoda N E > Mandibulata N E > Pancrustacea N E > Hexapoda N E > Insecta N E > Dicondylia N E > Pterygota N E > Neoptera N E > Holometabola N E > Diptera N E > Nematocera N E > Culicomorpha N E > Culicoidea N E > Culicidae N E > Culicinae N E > Aedini N E > Aedes N E > Stegomyia N E > Aedes aegypti N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

No inhibitor

Database

Sequence

Peptide

MFHTIEQSLK MSAANRINVK VHQGTVSGVR EKLPNGNESF AFRGIPYAKP PVGELRFKAP QPLDKFQYPI LDCSVERDVC FSRNMFTQEI EGSEDCLYLN VYSPKIGSDD KALPVMVFIH GGAFMFGSGN SDCYSPEYLV QEDVVAVTLN YRLGTLGFTY LPSQGIEGNS GLKDQLMALK WIKQNIAKFG GDPNNVTMFG ESAGAASVHL HLLSPNSRQY FHKAICQSGC SIMEWVMQRD PEYKARTLAK LIGCKGQSDE EVYETLMTSS TADVVGRMVS VLTDDEKIRG LPMPFKPVVE SESATDAIVT KAPIDVMKTP NAIPNIPVMM GVNNREGTIM LLDGIKKLEL YENDMARLIP RTVNVNPGTV ASNELGEEIK KFYFGNQPIT TKMLPQLADL MSDYHFSILA NVCCELHSRY QHQSPLYYYN FSFDGMLNMY KRLLNLKVPG ACHADELSYQ FLFRMAPVEV EPESPEARVR YYMCRMWTNF AKYGNPTPPE DSTLPYRWDP VGKIAAESKE DFQLNCLDIT EEPKMITNPD KHRMDFWRSV YRRFNEGMLK VKL

References (5)

Title : Carboxylesterase gene amplifications associated with insecticide resistance in Aedes albopictus: Geographical distribution and evolutionary origin - Grigoraki_2017_PLoS.Negl.Trop.Dis_11_e0005533
Author(s) : Grigoraki L , Pipini D , Labbe P , Chaskopoulou A , Weill M , Vontas J
Ref : PLoS Negl Trop Dis , 11 :e0005533 , 2017
PubMedID: 28394886
Gene_locus related to this paper: aedae-q17b28 , aedae-q17b31

Title : Functional and immunohistochemical characterization of CCEae3a, a carboxylesterase associated with temephos resistance in the major arbovirus vectors Aedes aegypti and Ae. albopictus - Grigoraki_2016_Insect.Biochem.Mol.Biol_74_61
Author(s) : Grigoraki L , Balabanidou V , Meristoudis C , Myridakis A , Ranson H , Swevers L , Vontas J
Ref : Insect Biochemistry & Molecular Biology , 74 :61 , 2016
PubMedID: 27180726
Gene_locus related to this paper: aedae-q17b28 , aedae-q17b31

Title : Transcriptome Profiling and Genetic Study Reveal Amplified Carboxylesterase Genes Implicated in Temephos Resistance, in the Asian Tiger Mosquito Aedes albopictus - Grigoraki_2015_PLoS.Negl.Trop.Dis_9_e0003771
Author(s) : Grigoraki L , Lagnel J , Kioulos I , Kampouraki A , Morou E , Labbe P , Weill M , Vontas J
Ref : PLoS Negl Trop Dis , 9 :e0003771 , 2015
PubMedID: 26000638
Gene_locus related to this paper: aedae-q17b28 , aedae-q17b31

Title : Identification of Carboxylesterase Genes Implicated in Temephos Resistance in the Dengue Vector Aedes aegypti - Poupardin_2014_PLoS.Negl.Trop.Dis_8_e2743
Author(s) : Poupardin R , Srisukontarat W , Yunta C , Ranson H
Ref : PLoS Negl Trop Dis , 8 :e2743 , 2014
PubMedID: 24651719
Gene_locus related to this paper: aedae-q17b28 , aedae-q17b31

Title : Genome sequence of Aedes aegypti, a major arbovirus vector - Nene_2007_Science_316_1718
Author(s) : Nene V , Wortman JR , Lawson D , Haas B , Kodira C , Tu ZJ , Loftus B , Xi Z , Megy K , Grabherr M , Ren Q , Zdobnov EM , Lobo NF , Campbell KS , Brown SE , Bonaldo MF , Zhu J , Sinkins SP , Hogenkamp DG , Amedeo P , Arensburger P , Atkinson PW , Bidwell S , Biedler J , Birney E , Bruggner RV , Costas J , Coy MR , Crabtree J , Crawford M , Debruyn B , Decaprio D , Eiglmeier K , Eisenstadt E , El-Dorry H , Gelbart WM , Gomes SL , Hammond M , Hannick LI , Hogan JR , Holmes MH , Jaffe D , Johnston JS , Kennedy RC , Koo H , Kravitz S , Kriventseva EV , Kulp D , LaButti K , Lee E , Li S , Lovin DD , Mao C , Mauceli E , Menck CF , Miller JR , Montgomery P , Mori A , Nascimento AL , Naveira HF , Nusbaum C , O'Leary S , Orvis J , Pertea M , Quesneville H , Reidenbach KR , Rogers YH , Roth CW , Schneider JR , Schatz M , Shumway M , Stanke M , Stinson EO , Tubio JM , Vanzee JP , Verjovski-Almeida S , Werner D , White O , Wyder S , Zeng Q , Zhao Q , Zhao Y , Hill CA , Raikhel AS , Soares MB , Knudson DL , Lee NH , Galagan J , Salzberg SL , Paulsen IT , Dimopoulos G , Collins FH , Birren B , Fraser-Liggett CM , Severson DW
Ref : Science , 316 :1718 , 2007
PubMedID: 17510324
Gene_locus related to this paper: aedae-ACHE , aedae-ACHE1 , aedae-glita , aedae-q0iea6 , aedae-q0iev6 , aedae-q0ifn6 , aedae-q0ifn8 , aedae-q0ifn9 , aedae-q0ifp0 , aedae-q0ig41 , aedae-q1dgl0 , aedae-q1dh03 , aedae-q1dh19 , aedae-q1hqe6 , aedae-Q8ITU8 , aedae-Q8MMJ6 , aedae-Q8T9V6 , aedae-q16e91 , aedae-q16f04 , aedae-q16f25 , aedae-q16f26 , aedae-q16f28 , aedae-q16f29 , aedae-q16f30 , aedae-q16gq5 , aedae-q16iq5 , aedae-q16je0 , aedae-q16je1 , aedae-q16je2 , aedae-q16ks8 , aedae-q16lf2 , aedae-q16lv6 , aedae-q16m61 , aedae-q16mc1 , aedae-q16mc6 , aedae-q16mc7 , aedae-q16md1 , aedae-q16ms7 , aedae-q16nk5 , aedae-q16rl5 , aedae-q16rz9 , aedae-q16si8 , aedae-q16t49 , aedae-q16wf1 , aedae-q16x18 , aedae-q16xp8 , aedae-q16xu6 , aedae-q16xw5 , aedae-q16xw6 , aedae-q16y04 , aedae-q16y05 , aedae-q16y06 , aedae-q16y07 , aedae-q16y39 , aedae-q16y40 , aedae-q16yg4 , aedae-q16z03 , aedae-q17aa7 , aedae-q17av1 , aedae-q17av2 , aedae-q17av3 , aedae-q17av4 , aedae-q17b28 , aedae-q17b29 , aedae-q17b30 , aedae-q17b31 , aedae-q17b32 , aedae-q17bm3 , aedae-q17bm4 , aedae-q17bv7 , aedae-q17c44 , aedae-q17cz1 , aedae-q17d32 , aedae-q17g39 , aedae-q17g40 , aedae-q17g41 , aedae-q17g42 , aedae-q17g43 , aedae-q17g44 , aedae-q17gb8 , aedae-q17gr3 , aedae-q17if7 , aedae-q17if9 , aedae-q17ig1 , aedae-q17ig2 , aedae-q17is4 , aedae-q17l09 , aedae-q17m26 , aedae-q17mg9 , aedae-q17mv4 , aedae-q17mv5 , aedae-q17mv6 , aedae-q17mv7 , aedae-q17mw8 , aedae-q17mw9 , aedae-q17nw5 , aedae-q17nx5 , aedae-q17pa4 , aedae-q17q69 , aedae-q170k7 , aedae-q171y4 , aedae-q172e0 , aedae-q176i8 , aedae-q176j0 , aedae-q177k1 , aedae-q177k2 , aedae-q177l9 , aedae-j9hic3 , aedae-q179r9 , aedae-u483 , aedae-j9hj23 , aedae-q17d68 , aedae-q177c7 , aedae-q0ifp1 , aedae-a0a1s4fx83 , aedae-a0a1s4g2m0 , aedae-q1hr49