Lipase_2

Relationship

Family: Lipase_2

Block: X

Parent Family: No family

Comment

Previously included in Fungal_triacylglycerol_lipase. This group of lipases has been called class 2 as they are not clearly related to other lipase families, and includes LipA and LipB from Bacillus subtilis and uncharacterised proteins from Caenorhabditis. Two other subfamilies described in: Arpigny and Jaeger (1999), Jaeger and Eggert (Family I.4 and Family I.7) are included in Lipase_2 (see classification). A novel type of hydrolase purified from Paucimonas revealed an unusual substrate specificity for amorphous poly((R)-3-hydroxyalkanoates PHA and no homologies to any other PHB depolymerase. A new family was built and extracted form Lipase_2 PHAZ7_phb_depolymerase (Arpigny_Jaeger Family IX)

Database

Interpro : IPR002918 Lipase EstA\/Esterase EstB

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF01674 Lipase_2

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (26)

Genes Proteins in Lipase_2 family (183)

Fragments of genes in Lipase_2 family (6)

Structures in Lipase_2 family (26)

Substrates in Lipase_2 family (24)

Inhibitors in Lipase_2 family (2)

References (6)

Title : Biophysical characterization of mutants of Bacillus subtilis lipase evolved for thermostability: factors contributing to increased activity retention - Augustyniak_2012_Protein.Sci_21_487
Author(s) : Augustyniak W , Brzezinska AA , Pijning T , Wienk H , Boelens R , Dijkstra BW , Reetz MT
Ref : Protein Science , 21 :487 , 2012
PubMedID: 22267088
Gene_locus related to this paper: bacsu-lip

Title : Structural basis of selection and thermostability of laboratory evolved Bacillus subtilis lipase - Acharya_2004_J.Mol.Biol_341_1271
Author(s) : Acharya P , Rajakumara E , Sankaranarayanan R , Rao NM
Ref : Journal of Molecular Biology , 341 :1271 , 2004
PubMedID: 15321721
Gene_locus related to this paper: bacsu-lip

Title : Lipases for biotechnology - Jaeger_2002_Curr.Opin.Biotechnol_13_390
Author(s) : Jaeger KE , Eggert T
Ref : Curr Opin Biotechnol , 13 :390 , 2002
PubMedID: 12323363

Title : A new type of thermoalkalophilic hydrolase of Paucimonas lemoignei with high specificity for amorphous polyesters of short chain-length hydroxyalkanoic acids - Handrick_2001_J.Biol.Chem_276_36215
Author(s) : Handrick R , Reinhardt S , Focarete ML , Scandola M , Adamus G , Kowalczuk M , Jendrossek D
Ref : Journal of Biological Chemistry , 276 :36215 , 2001
PubMedID: 11457823
Gene_locus related to this paper: psele-PHAZ7

Title : Lipolytic enzymes LipA and LipB from Bacillus subtilis differ in regulation of gene expression, biochemical properties, and three-dimensional structure - Eggert_2001_FEBS.Lett_502_89
Author(s) : Eggert T , van Pouderoyen G , Dijkstra BW , Jaeger KE
Ref : FEBS Letters , 502 :89 , 2001
PubMedID: 11583117
Gene_locus related to this paper: bacsu-lip , bacsu-LIPB

Title : Bacterial lipolytic enzymes: classification and properties - Arpigny_1999_Biochem.J_343_177
Author(s) : Arpigny JL , Jaeger KE
Ref : Biochemical Journal , 343 :177 , 1999
PubMedID: 10493927