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Family Report for: Monoglyceridelipase_lysophospholip

Monoglyceridelipase_lysophospholip



Relationship
Block X
Parent Family : Hydrolase_4

Comment
This family consists of Monoglyceridelipase_lysophospholipase but different of phospholipases and carboxylesterases with broad substrate specificity. Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth.The closest family is CarbLipBact

Database
Sequences
Interpro
|
IPR022742 (Alpha/beta hydrolase, N-terminal)
PIRSF
|
Pdoc
|
PFam
|
PF12146 (Hydrolase_4)
Prints
|
Prosite
|
EC at KEGG
|
EC at EXPASY
|


Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
11 more
    Title: Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase
    Butler CR, Beck EM, Harris A, Huang Z, McAllister LA, Am Ende CW, Fennell K, Foley TL, Fonseca K and Brodney MA <12 more author(s)>
    Ref: Journal of Medicinal Chemistry, 60:9860, 2017 : PubMed

            

    Title: Inhibition of the endocannabinoid-regulating enzyme monoacylglycerol lipase elicits a CB1 receptor-mediated discriminative stimulus in mice
    Owens RA, Mustafa MA, Ignatowska-Jankowska BM, Damaj MI, Beardsley PM, Wiley JL, Niphakis MJ, Cravatt BF, Lichtman AH
    Ref: Neuropharmacology, 125:80, 2017 : PubMed

            

    Title: Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling
    Labar G, Bauvois C, Borel F, Ferrer JL, Wouters J, Lambert DM
    Ref: Chembiochem, 11:218, 2010 : PubMed

            

Other Papers


No structure scheme yet for this family

Structures in Monoglyceridelipase_lysophospholip family (26)

Genes Proteins in Monoglyceridelipase_lysophospholip family (1179)

Fragments of genes in Monoglyceridelipase_lysophospholip family (102)

Substrates of some enzymes in the Monoglyceridelipase_lysophospholip family (16)

Inhibitors of some enzymes in the Monoglyceridelipase_lysophospholip family (63)



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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