Gene_Locus Report

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Gene_locus Report for: myctu-bpoC

Mycobacterium tuberculosis, Mycobacterium bovis, Rv0554 MT0580 bpoC bromoperoxidase, putative

Comment
There are more than 1000 strains. Other Uniprot entries and list of strains can be found with the link: Other strains. no binding of ligands related to menaquinone biosynthesis could be detected and functional assays failed to support possible roles in menaquinone biosynthesis


Relationship
Family|6_AlphaBeta_hydrolase
Block| X
Position in NCBI Life Tree|Mycobacterium tuberculosis
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Bacteria: N E > Terrabacteria group: N E > Actinobacteria [phylum]: N E > Actinobacteria [class]: N E > Corynebacteriales: N E > Mycobacteriaceae: N E > Mycobacterium: N E > Mycobacterium tuberculosis complex: N E > Mycobacterium tuberculosis: N E
Warning: This entry is a compilation of different species or line or strain with more than 90% amino acid identity. You can retrieve all strain data


Molecular evidence
Database
No mutation
5 structures (e.g. : 3E3A, 3HSS, 3HYS... more)
No kinetic





No Substrate
1 inhbitor:
Malonic-acid
Sequence
Graphical view for this peptide sequence: myctu-bpoC
Colored MSA for 6_AlphaBeta_hydrolase (raw)
MINLAYDDNGTGDPVVFIAGRGGAGRTWHPHQVPAFLAAGYRCITFDNRG
IGATENAEGFTTQTMVADTAALIETLDIAPARVVGVSMGAFIAQELMVVA
PELVSSAVLMATRGRLDRARQFFNKAEAELYDSGVQLPPTYDARARLLEN
FSRKTLNDDVAVGDWIAMFSMWPIKSTPGLRCQLDCAPQTNRLPAYRNIA
APVLVIGFADDVVTPPYLGREVADALPNGRYLQIPDAGHLGFFERPEAVN
TAMLKFFASVKA
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MINLAYDDNGTGDPVVFIAGRGGAGRTWHPHQVPAFLAAGYRCITFDNRG
IGATENAEGFTTQTMVADTAALIETLDIAPARVVGVSMGAFIAQELMVVA
PELVSSAVLMATRGRLDRARQFFNKAEAELYDSGVQLPPTYDARARLLEN
FSRKTLNDDVAVGDWIAMFSMWPIKSTPGLRCQLDCAPQTNRLPAYRNIA
APVLVIGFADDVVTPPYLGREVADALPNGRYLQIPDAGHLGFFERPEAVN
TAMLKFFASVKA


References
4 more
    Title: The alpha/beta Hydrolase Fold Proteins of Mycobacterium tuberculosis, With Reference to their Contribution to Virulence
    Johnson G
    Ref: Curr Protein Pept Sci, 18:190, 2016 : PubMed

            

    Title: Structural and functional analysis of Rv0554 from Mycobacterium tuberculosis: testing a putative role in menaquinone biosynthesis
    Johnston JM, Jiang M, Guo Z, Baker EN
    Ref: Acta Crystallographica D Biol Crystallogr, 66:909, 2010 : PubMed

            

    Title: Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains
    Fleischmann RD, Alland D, Eisen JA, Carpenter L, White O, Peterson J, Deboy R, Dodson R, Gwinn M and Fraser CM <16 more author(s)>
    Ref: Journal of Bacteriology, 184:5479, 2002 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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