Mycobacterium tuberculosis, Mycobacterium bovis Rv3487c Carboxylesterase/phospholipase lipF
(from Uniprot) Hydrolyzes short-chain esters. Shows maximal activity with triacetin and p-nitrophenyl acetate. Has no enzyme activity on triacylglycerides or p-nitrophenyl esters (p-NP) with long fatty acids (tricaprin, p-NP caprylate, or p-NP caprate)\; experiments performed with enzyme missing the first 97 residues (PubMed:15939293). Has phospholipase C activity, making 1,2-DAG phosphocholine\; experiments performed with enzyme missing the first 97 residues. There are more than 3000 strains. Other Uniprot entries and list of strains can be found with the link: Other strains
Family : Hormone-sensitive_lipase_like
Block : H
Position in NCBI Life Tree : Mycobacterium tuberculosis
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Bacteria N E > Terrabacteria group N E > Actinobacteria [phylum] N E > Actinobacteria [class] N E > Corynebacteriales N E > Mycobacteriaceae N E > Mycobacterium N E > Mycobacterium tuberculosis complex N E > Mycobacterium tuberculosis N EVRAPGVRAAD GAGRVVLYLH GGAFVMCGPN SHSRIVNALS GFAESPVLIV DYRLIPKHSL GMALDDCHDA YQWLRARGYR PEQIVLAGDS AGGYLALALA QRLQCDDEKP AAIVAISPLL QLAKGPKQDH PNIGTDAMFP ARAFDALAAW VRAAAAKNMV DGRPEDLYEP LDHIESSLPP TLIHVSGSEV LLHDAQLGAG KLAAAGVCAE VRVWPGQAHL FQLATPLVPE ATRSLRQIGQ FIRDATADSS LSPVHRSRYV AGSPRAASRG AFGQSPI
| Title : Expression and characterization of the carboxyl esterase Rv3487c from Mycobacterium tuberculosis - Zhang_2005_Protein.Expr.Purif_42_59 |
| Author(s) : Zhang M , Wang JD , Li ZF , Xie J , Yang YP , Zhong Y , Wang HH |
| Ref : Protein Expr Purif , 42 :59 , 2005 |
| Abstract : |
| PubMedSearch : Zhang_2005_Protein.Expr.Purif_42_59 |
| PubMedID: 15939293 |
| Gene_locus related to this paper: myctu-Rv3487c |
| Title : Identification of a virulence gene cluster of Mycobacterium tuberculosis by signature-tagged transposon mutagenesis - Camacho_1999_Mol.Microbiol_34_257 |
| Author(s) : Camacho LR , Ensergueix D , Perez E , Gicquel B , Guilhot C |
| Ref : Molecular Microbiology , 34 :257 , 1999 |
| Abstract : |
| PubMedSearch : Camacho_1999_Mol.Microbiol_34_257 |
| PubMedID: 10564470 |
| Gene_locus related to this paper: myctu-Rv3487c |
| Title : An integrated map of the genome of the tubercle bacillus, Mycobacterium tuberculosis H37Rv, and comparison with Mycobacterium leprae - Philipp_1996_Proc.Natl.Acad.Sci.U.S.A_93_3132 |
| Author(s) : Philipp WJ , Poulet S , Eiglmeier K , Pascopella L , Balasubramanian V , Heym B , Bergh S , Bloom BR , Jacobs WR, Jr. , Cole ST |
| Ref : Proc Natl Acad Sci U S A , 93 :3132 , 1996 |
| Abstract : |
| PubMedSearch : Philipp_1996_Proc.Natl.Acad.Sci.U.S.A_93_3132 |
| PubMedID: 8610181 |
| Gene_locus related to this paper: myctu-Rv0217c , myctu-Rv0220 , myctu-Rv1076 , myctu-Rv1399c , myctu-Rv1400c , myctu-Rv1426c , myctu-Rv2045c , myctu-Rv2284 , myctu-Rv2385 , myctu-Rv2485c , myctu-Rv2970c , myctu-Rv3084 , myctu-Rv3097c , myctu-Rv3487c |