Mycobacterium tuberculosis, Mycobacterium bovis, Esterase lipC Rv0220
Rv0220 gene lipC MTCY8D5.15 Orf 15 of MTCY8D5, old myctu-este2. || Esterase that can hydrolyze short-chain esters with the carbon chain containing 2 to 10 carbon atoms. Does not have lipase activity. Is highly immunogenic and elicits strong humoral immune responses in both HIV-negative (HIV-) and HIV-positive (HIV+) tuberculosis (TB) patients. Also elicits pro-inflammatory cytokine and chemokine responses from macrophages and pulmonary epithelial cells. May participate in the progression of active tuberculosis both by contributing to the utilization of lipid substrates for bacterial growth and replication, and by modulating immune responses There are more than 1000 strains. Other Uniprot entries and list of strains can be found with the link: Other strains
MNQRRAAGST GVAYIRWLLR ARPADYMLAL SVAGGSLPVV GKHLKPLGGV TAIGVWGARH ASDFLSATAK DLLTPGINEV RRRDRASTQE VSVAALRGIV SPDDLAVEWP APERTPPVCG ALRHRRYVHR RRVLYGDDPA QLLDVWRRKD MPTKPAPVLI FVPGGAWVHG SRAIQGYAVL SRLAAQGWVC LSIDYRVAPH HRWPRHILDV KTAIAWARAN VDKFGGDRNF IAVAGCSAGG HLSALAGLTA NDPQYQAELP EGSDTSVDAV VGIYGRYDWE DRSTPERARF VDFLERVVVQ RTIDRHPEVF RDASPIQRVT RNAPPFLVIH GSRDCVIPVE QARSFVERLR AVSRSQVGYL ELPGAGHGFD LLDGARTGPT AHAIALFLNQ VHRSRAQFAK EVI
Title : LipC (Rv0220) is an immunogenic cell surface esterase of Mycobacterium tuberculosis - Shen_2012_Infect.Immun_80_243 |
Author(s) : Shen G , Singh K , Chandra D , Serveau-Avesque C , Maurin D , Canaan S , Singla R , Behera D , Laal S |
Ref : Infect Immun , 80 :243 , 2012 |
Abstract : Shen_2012_Infect.Immun_80_243 |
ESTHER : Shen_2012_Infect.Immun_80_243 |
PubMedSearch : Shen_2012_Infect.Immun_80_243 |
PubMedID: 22038913 |
Gene_locus related to this paper: myctu-Rv0220 |
Title : An integrated map of the genome of the tubercle bacillus, Mycobacterium tuberculosis H37Rv, and comparison with Mycobacterium leprae - Philipp_1996_Proc.Natl.Acad.Sci.U.S.A_93_3132 |
Author(s) : Philipp WJ , Poulet S , Eiglmeier K , Pascopella L , Balasubramanian V , Heym B , Bergh S , Bloom BR , Jacobs WR, Jr. , Cole ST |
Ref : Proc Natl Acad Sci U S A , 93 :3132 , 1996 |
Abstract : Philipp_1996_Proc.Natl.Acad.Sci.U.S.A_93_3132 |
ESTHER : Philipp_1996_Proc.Natl.Acad.Sci.U.S.A_93_3132 |
PubMedSearch : Philipp_1996_Proc.Natl.Acad.Sci.U.S.A_93_3132 |
PubMedID: 8610181 |
Gene_locus related to this paper: myctu-Rv0217c , myctu-Rv0220 , myctu-Rv1076 , myctu-Rv1399c , myctu-Rv1400c , myctu-Rv1426c , myctu-Rv2045c , myctu-Rv2284 , myctu-Rv2385 , myctu-Rv2485c , myctu-Rv2970c , myctu-Rv3084 , myctu-Rv3097c , myctu-Rv3487c |