Sarin

The organophosphate nerve agents tabun (GA), sarin (GB), soman (GD), and cyclosarin (GF) are among the most toxic chemical warfare agents known. The G-series nerve agents are named because German scientists led by Dr Gerhard Schraderfirst synthesized them during World War II, beginning with GA in 1936. GB was discovered next in 1938, followed by GD in 1944 and finally GF in 1949. The only other known nerve agent, O-ethyl S-(2-diisopropylaminoethyl) methylphosphonothioate (VX), V-series - VE, VG, VM, Russian VX). G-series nerve agents share a number of common physical and chemical properties. At room temperature, the G-series nerve agents are volatile liquids, making them a serious risk for 2 types of exposure: dermal contact with liquid nerve agent or inhalation of nerve agent vapor.Sarin is an acronym for the names of the members of the development team: Schrader. Ambrose. Rudriger. and van der Linde. The Germans deignated it T-I44 or Trilon-46. The United Slates eventually designated it GB

General

Type : Chemical Warfare Agent, Organophosphate, Nerve Agent G-series, Derivative of Sarin

Chemical_Nomenclature : 2-[fluoro(methyl)phosphoryl]oxypropane

Canonical SMILES : CC(C)OP(=O)(C)F

InChI : InChI=1S\/C4H10FO2P\/c1-4(2)7-8(3,5)6\/h4H,1-3H3

InChIKey : DYAHQFWOVKZOOW-UHFFFAOYSA-N

Other name(s) : Zarin  ||  Sarin II  ||  Trilone 46  ||  IMPF  ||  Methylphosphonofluoridic acid 1-methyl-ethyl esther  ||  Isopropylmethylphosphonofluoridate  ||  Isopropoxymethylphosphorylfluoride  ||  GB  ||  T144  ||  T-144  ||  Trilon-46


MW : 140.09

Formula : C4H10FO2P

CAS_number : 107-44-8

PubChem : 7871

UniChem : DYAHQFWOVKZOOW-UHFFFAOYSA-N

Wikipedia : Sarin

Target

Families : Sarin ligand of proteins in family
ACHE BCHE PAF-Acetylhydrolase Carboxypeptidase_S10

Structure :
1CFJ 7R0A 7BFU 6WUZ 6WV1 5FPP 5FPQ 2Y2V 2WHP 2WHQ 3F96 2JGL

Protein :
human-ACHE human-BCHE human-CTSA

References (48)

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Title : Enzyme-kinetic investigation of different sarin analogues reacting with human acetylcholinesterase and butyrylcholinesterase - Bartling_2007_Toxicology_233_166
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Gene_locus related to this paper: human-BCHE

Title : A preliminary study on delayed vestibulo-cerebellar effects of Tokyo Subway Sarin Poisoning in relation to gender difference: frequency analysis of postural sway - Yokoyama_1998_J.Occup.Environ.Med_40_17
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Gene_locus related to this paper: torca-ACHE

Title : Reactivating potency of obidoxime, pralidoxime, HI 6 and HLo 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds - Worek_1998_Arch.Toxicol_72_237
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Title : Sarin poisoning on Tokyo subway - Ohbu_1997_South.Med.J_90_587
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Title : Studies on low dose sub-acute administration of soman, sarin and tabun in the rat - Dulaney_1985_Acta.Pharmacol.Toxicol.(Copenh)_57_234
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