Family

Go to basket

Tree Display

AceDB Schema

XML Display

Feedback

Family Report for: ABHD6-Lip

ABHD6-Lip



Relationship
Family ABHD6-Lip
Block X
Parent Family : Epoxide-hydrolase_like

Comment
Monoacylglycerol lipase ABHD6 hydrolyses the endocannabinoid 2-arachidonoylglycerol (2-AG). 2-AG regulates neurotransmission and neuroinflammation by activating CB1 cannabinoid receptors on neurons and CB2 cannabinoid receptors on microglia. (A MGLL human-MGLL or MAGLL is the other enzyme hydrolyzing 26AG (belongs to Monoglyceridelipase_lysophospholip family). . Alpha/beta-Hydrolase domain 6 deletion induces adipose browning and prevents obesity and type 2 diabetes and is published by Zhao et al.. A study by Wei et al. shows that ABHD6 negatively regulates the surface delivery and synaptic function of AMPA receptors independantly of hydrolase activity. ABHD6 hydrolyzes Bis(monoacylglycerol)phosphate (BMP): a phospholipid crucial for lipid degradation and sorting in acidic organelles and accumulating in Lysosomal storage disorders Pribasnig et al. ABHD6 of animals is homologous to some bacterial enzymes. For bacterial enzymes, this family correspond to family V.1 of the classification of Arpigny and Jaeger 1999 Membrane phospholipid remodeling by a bacterial Lands cycle phospholipase A is published by Bleffert et al. PlaF dimerization, mediated solely through the intermolecular interactions of TM and juxtamembrane regions, inhibits its activity. (6I8W)

Database
Sequences
Interpro
|
PIRSF
|
Pdoc
|
PFam
|
Prints
|
Prosite
|
no EC number



Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
23 more
    Title: Evidence for a bacterial Lands cycle phospholipase A: Structural and mechanistic insights into membrane phospholipid remodeling
    Bleffert F, Granzin J, Caliskan M, Schott-Verdugo SN, Siebers M, Thiele B, Rahme L, Felgner S, Dormann P and Kovacic F <3 more author(s)>
    Ref: Biorxiv, :, 2021 : PubMed

            

    Title: Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status
    Miralpeix C, Reguera AC, Fosch A, Casas M, Lillo J, Navarro G, Franco R, Casas J, Alexander SPH and Rodriguez-Rodriguez R <1 more author(s)>
    Ref: British Journal of Pharmacology, 178:1507, 2021 : PubMed

            

    Title: Alpha/Beta-Hydrolase Domain-Containing 6: Signaling and Function in the Central Nervous System
    Zhang H, Li X, Liao D, Luo P, Jiang X
    Ref: Front Pharmacol, 12:784202, 2021 : PubMed

            

Other Papers


No structure scheme yet for this family

Structures in ABHD6-Lip family (4)

Genes Proteins in ABHD6-Lip family (155)

Fragments of genes in ABHD6-Lip family (3)

Substrates of some enzymes in the ABHD6-Lip family (8)

Inhibitors of some enzymes in the ABHD6-Lip family (24)



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer