2024

Liao_2024_Biotechnol.Lett__ Essential amino acid residues and catalytic mechanism of trans-epoxysuccinate hydrolase for production of meso-tartaric acid
Zhang_2024_Int.J.Biol.Macromol_269_132082 Multiple strategies to improve extracellular secretion and activity of feruloyl esterase
Xu_2024_Bull.Entomol.Res__1 SlCarE054 in Spodoptera litura (Lepidoptera: Noctuidae) showed direct metabolic activity to beta-cypermethrin with stereoselectivity
Jing_2024_J.Agric.Food.Chem_72_11221 Overexpression of an Integument Esterase Gene LbEST-inte4 Infers the Malathion Detoxification in Liposcelis bostrychophila (Psocoptera: Liposcelididae)
Jiang_2024_J.Hazard.Mater_472_134493 Novel polyurethane-degrading cutinase BaCut1 from Blastobotrys sp. G-9 with potential role in plastic bio-recycling
Kataoka_2024_FEBS.Lett__ Structural and functional insights into the enzymatic activities of lipases from Burkholderia stagnalis and Burkholderia plantarii
Roman_2024_Appl.Environ.Microbiol__e0169423 Identification and recombinant expression of a cutinase from Papiliotrema laurentii that hydrolyzes natural and synthetic polyesters
De Witt_2024_Microb.Biotechnol_17_e14362 Biodegradation of poly(ester-urethane) coatings by Halopseudomonas formosensis
Cao_2024_J.Agric.Food.Chem__ Highly Sensitive and Rapid Screening Technique for the Detection of Organophosphate Pesticides and Copper Compounds Using Bifunctional Recombinant TrxA-PvCarE1
Zan_2024_Process.Biochem_137_164 Structural characteristics and catalysis properties of a dual-functional enzyme Lip10 from Mucor circinelloides
Neoh_2024_Microb.Cell.Fact_23_52 N-terminal truncation of PhaC(BP-M-CPF4) and its effect on PHA production
Liu_2024_Appl.Environ.Microbiol__e0147723 Identification and characterization of a fungal cutinase-like enzyme CpCut1 from Cladosporium sp. P7 for polyurethane degradation
Chandravanshi_2024_FEBS.Lett__ Crystal structure and solution scattering of Geobacillus stearothermophilus S9 peptidase reveal structural adaptations for carboxypeptidase activity
Das_2024_bioRxiv__ Unlocking prophage potential: In silico and experimental analysis of a novel Mycobacterium fortuitum LysinB containing a peptidoglycan-binding domain
Sanchez-Arroyo_2024_Appl.Microbiol.Biotechnol_108_230 A new and promiscuous alpha\/beta hydrolase from Acinetobacter tandoii DSM 14970( T) inactivates the mycotoxin ochratoxin A
Phienluphon_2024_ACS.Sustain.Chem.Eng__ Structure-Based Characterization and Improvement of an Enzymatic Activity of Acremonium alcalophilum Feruloyl Esterase
Fruhauf_2024_ACS.Catal_14_3392 Bacterial Lactonases ZenA with Noncanonical Structural Features Hydrolyse the Mycotoxin Zearalenone
Wang_2024_Mol.Plant.Pathol_25_e13431 The secreted feruloyl esterase of Verticillium dahliae modulates host immunity via degradation of GhDFR
Zhou_2024_Microorganisms_12_138 Polyethylene Terephthalate Hydrolases in Human Gut Microbiota and Their Implications for Human Health
Holtsclaw_2024_Plant.Mol.Biol_114_4 Identification and characterization of GLYCEROLIPASE A1 for wound-triggered JA biosynthesis in Nicotiana benthamiana leaves
Zhou_2024_Front.Microbiol_14_1320827 Characteristics of a lipase ArEstA with lytic activity against drug-resistant pathogen from a novel myxobacterium, Archangium lipolyticum sp. nov
Yan_2024_Int.J.Biol.Macromol__129538 Complete degradation of PET waste using a thermophilic microbe-enzyme system
He_2024_J.Ocean.Univ.China_23_221 Characterization of a Novel Esterase Belonging to Family V from Marinobacter flavimaris
Adjeroud_2024_Appl.Microbiol.Biotechnol_108_1 AMWEst, a new thermostable and detergent-tolerant esterase retrieved from the Albian aquifer
Wang_2024_ChemSusChem__e202301735 Discovery and Mechanistic Understanding of a Lipase from Rhizorhabdus dicambivorans for Efficient Ester Aminolysis in Aromatic Amines
Bergmann_2024_Sci.Rep_14_377 New dienelactone hydrolase from microalgae bacterial community-Antibiofilm activity against fish pathogens and potential applications for aquaculture
Seveso_2024_Appl.Environ.Microbiol__e0176823 Polysaccharide utilization loci from Bacteroidota encode CE15 enzymes with possible roles in cleaving pectin-lignin bonds
Hwang_2024_Int.J.Biol.Macromol__130419 Structural insights into the distinct substrate preferences of two bacterial epoxide hydrolases
Hong_2024_Nat.Commun_15_8 Molecular basis of the inositol deacylase PGAP1 involved in quality control of GPI-AP biogenesis
Madsen_2024_Enzyme.Microb.Technol_178_110444 Efficient activity screening of new glucuronoyl esterases using a pNP-based assay
Erdem_2024_Exp.Appl.Acarol__ Geographical distribution of pyrethroid resistance mutations in Varroa destructor across Turkiye and a European overview
Johan_2024_Arch.Biochem.Biophys__109996 Thermodynamics of a Hyperthermostable Carboxylesterase from Anoxybacillus geothermalis D9
Pinto_2024_Curr.Res.Struct.Biol_7_100130 Assessment of Kaistella jeonii esterase conformational dynamics in response to poly(ethylene terephthalate) binding
Rennison_2024_Chembiochem__e202300661 Unveiling PET Hydrolase Surface Dynamics through Fluorescence Microscopy
Vinces_2024_Biochemistry__ Monomeric Esterase: Insights into Cooperative Behavior, Hysteresis\/Allokairy
Makryniotis_2024_Biotechnol.J__e2400053 Exploring the substrate spectrum of phylogenetically distinct bacterial polyesterases
Burgin_2024_Commun.Chem_7_65 The reaction mechanism of the Ideonella sakaiensis PETase enzyme
Chen_2024_Chem.Eng.J_481_148418 Complete decomposition of poly(ethylene terephthalate) by crude PET hydrolytic enzyme produced in Pichia pastoris
Xin_2024_Biotechnol.J_19_e2300723 Depolymerization of the polyester-polyurethane by amidase GatA250 and enhancing the production of 4,4'-methylenedianiline with cutinase LCC
Schubert_2024_ChemSusChem__e202301752 Relationships of crystallinity and reaction rates for enzymatic degradation of poly (ethylene terephthalate), PET
Oda_2024_Biochemistry__ Development of Enzyme-Based Approaches for Recycling PET on an Industrial Scale
Charlier_2024_Biophys.J__ Exploring the pH dependence of an improved PETase
Sahihi_2024_J.Chem.Inf.Model__ Probing Enzymatic PET Degradation: Molecular Dynamics Analysis of Cutinase Adsorption and Stability
Poulton_2024_PLoS.Negl.Trop.Dis_18_e0011595 Aedes aegypti CCEae3A carboxylase expression confers carbamate, organophosphate and limited pyrethroid resistance in a model transgenic mosquito
Zhao_2024_Stress.Biol_4_23 Improvement of plant resistance to geminiviruses via protein de-S-acylation
Mu_2024_Biotechnol.Rep.(Amst)_42_e00840 Identification and characterisation of moderately thermostable diisobutyl phthalate degrading esterase from a Great Artesian Basin Bacillus velezensis NP05
Jaufer_2024_J.Phys.Chem.B__ Hydrophobic Clusters Regulate Surface Hydration Dynamics of Bacillus subtilis Lipase A
Shi_2024_J.Agric.Food.Chem__ Characterization, Structural Analysis, and Thermal Stability Mutation of a New Zearalenone-Degrading Enzyme Mined from Bacillus subtilis
Garcia-Sanz_2024_Nanoscale__ Design of a gold nanoparticles site in an engineered lipase: an artificial metalloenzyme with enantioselective reductase-like activity
Cossio-Bayugar_2024_Parasite_31_3 Relationship between acaricide resistance and acetylcholinesterase gene polymorphisms in the cattle tick Rhipicephalus microplus
de Barros_2024_Langmuir_40_5663 Unraveling the Nano-Bio Interface Interactions of a Lipase Adsorbed on Gold Nanoparticles under Laser Excitation
Sequeiros-Borja_2024_J.Chem.Inf.Model__ Water will Find Its Way: Transport through Narrow Tunnels in Hydrolases
Pena-Montes_2024_Biotechnol.Lett__ ANCUT1, a novel thermoalkaline cutinase from Aspergillus nidulans and its application on hydroxycinnamic acids lipophilization
DeMars_2024_Proc.Natl.Acad.Sci.U.S.A_121_e2318586121 Evolution and diversification of carboxylesterase-like [4+2] cyclases in aspidosperma and iboga alkaloid biosynthesis
Kaur_2024_Pestic.Biochem.Physiol_200_105844 Heterologous expression, biochemical characterization and prospects for insecticide biosensing potential of carboxylesterase Ha006a from Helicoverpa armigera
Nagaoka_2024_Biochem.Pharmacol__116128 Role of carboxylesterase and arylacetamide deacetylase in drug metabolism, physiology, and pathology
Lv_2024_Int.J.Chron.Obstruct.Pulmon.Dis_19_33 Abhd2, a Candidate Gene Regulating Airway Remodeling in COPD via TGF-beta
Xiong_2024_Mol.Carcinog__ ABHD6 suppresses colorectal cancer progression via AKT signaling pathway
Lane_2024_BMC.Neurol_24_116 Onset of Alzheimer disease in apolipoprotein sigma4 carriers is earlier in butyrylcholinesterase K variant carriers
Hussain_2024_J.Appl.Genet__ Pharmacogenetic study of CES1 gene and enalapril efficacy
Cumitini_2024_J.Clin.Med_13_2545 Role of CES1 and ABCB1 Genetic Polymorphisms on Functional Response to Dabigatran in Patients with Atrial Fibrillation
Olserova_2024_Am.J.Ther__ The Effect of ABCB1 and CES1 Polymorphisms on Plasma Levels of Dabigatran and Risk of Hemorrhagic Complications in Ischemic Stroke Patients
Kailass_2024_J.Med.Chem__ Tight-Binding Small-Molecule Carboxylesterase 2 Inhibitors Reduce Intracellular Irinotecan Activation
Miske_2024_J.Neurol.Neurosurg.Psychiatry__ Identification of DAGLA as an autoantibody target in cerebellar ataxia
Ramos-Medina_2024_Psychopharmacology.(Berl)__ Pharmacological diacylglycerol lipase inhibition impairs contextual fear extinction in mice
Failayev_2024_Virus.Res__199330 Molecular insights on the coronavirus MERS-CoV interaction with the CD26 receptor
Gnoth_2024_PLoS.One_19_e0289239 Contribution of amino acids in the active site of dipeptidyl peptidase 4 to the catalytic action of the enzyme
Neo_2024_Mov.Disord.Clin.Pract_11_97 Neuropsychiatric Presentation of Anti-DPPX Progressive Encephalomyelitis with Rigidity and Myoclonus
Wan_2024_Ther.Apher.Dial_28_141 The effect of double filtration plasmapheresis and corticosteroids on patients with anti-dipeptidyl-peptidase-like protein 6 encephalitis
Jin_2024_BMC.Neurol_24_34 A rare case of anti-DPPX encephalitis combined with neuroleptospirosis
Lu_2024_Clin.Nucl.Med__ Colocalization of Increased Midbrain Signals in Neuroinflammation and Tau PET Imaging Suggests the Diagnosis of Progressive Supranuclear Palsy
Hess_2024_Biochim.Biophys.Acta.Mol.Basis.Dis__167133 Dipeptidyl-peptidase 9 regulates the dynamics of tumorigenesis and metastasis in breast cancer
Li_2024_Biochimie__ Inhibition of soluble epoxide hydrolase as a therapeutic approach for blood-brain barrier dysfunction
Dotsch_2024_J.Med.Chem__ Discovery of the sEH Inhibitor Epoxykynin as a Potent Kynurenine Pathway Modulator
Li_2024_Science_383_498 Photosensitization enables Pauson-Khand-type reactions with nitrenes
Shen_2024_Cell.Rep_43_113720 ABHD7-mediated depalmitoylation of lamin A promotes myoblast differentiation
Zhao_2024_Methods.Cell.Biol_184_119 Characterization of lysosomal acid lipase in Ly6G(+) and CD11c(+) myeloid-derived suppressor cells
Chen_2024_Proc.Natl.Acad.Sci.U.S.A_121_e2322332121 Carboxyl-terminal sequences in APOA5 are important for suppressing ANGPTL3\/8 activity
Harris_2024_Proteins__ A conserved but structurally divergent loop in acyl protein thioesterase 1 regulates its catalytic activity, ligand binding, and folded stability
Zhou_2024_Theranostics_14_1583 MAGL protects against renal fibrosis through inhibiting tubular cell lipotoxicity
Butini_2024_J.Med.Chem__ Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization
Mikkelsen_2024_Neurochem.Int__105717 Binding of the monoacylglycerol lipase (MAGL) radiotracer [(3)H]T-401 in the rat brain after status epilepticus
Leduc_2024_Mol.Autism_15_13 Neuroligin-2 shapes individual slow waves during slow-wave sleep and the response to sleep deprivation in mice
Diamanti_2024_Traffic_25_e12930 Glucocorticoids rescue cell surface trafficking of R451C Neuroligin3 and enhance synapse formation
Li_2024_Psychopharmacology.(Berl)__ Mice with an autism-associated R451C mutation in neuroligin-3 show intact attention orienting but atypical responses to methylphenidate and atomoxetine in the mouse-Posner task
Pizzarelli_2024_Front.Cell.Neurosci_17_1332179 Insulin-like growth factor 2 (IGF-2) rescues social deficits in NLG3(-\/y) mouse model of ASDs
Guo_2024_Front.Biosci.(Landmark.Ed)_29_39 Bioinformatics Analysis Identifies PLA2G7 as a Key Antigen-Presenting Prognostic Related Gene Promoting Hepatocellular Carcinoma through the STAT1\/PD-L1 Axis
Zhang_2024_J.Immunother.Cancer_12_e008094 Inhibiting PLA2G7 reverses the immunosuppressive function of intratumoral macrophages and augments immunotherapy response in hepatocellular carcinoma
Zhai_2024_J.Agric.Food.Chem__ Kj-mhpC Enzyme in Klebsiella jilinsis 2N3 Is Involved in the Degradation of Chlorimuron-Ethyl via De-Esterification
Ozawa_2024_Cell.Rep.Phys.Sci_5_ Development of evolutionary algorithm-based protein redesign method
Wu_2024_Chemosphere__141921 Integrated transcriptomics and metabolomics analyses reveal the aerobic biodegradation and molecular mechanisms of 2,3',4,4',5-pentachlorodiphenyl (PCB 118) in Methylorubrum sp. ZY-1
Hosie_2024_Int.J.Mol.Sci_25_ Faster Gastrointestinal Transit, Reduced Small Intestinal Smooth Muscle Tone and Dysmotility in the Nlgn3(R451C) Mouse Model of Autism
Skoug_2024_J.Neurochem__ Genetic deletion of hormone-sensitive lipase in mice reduces cerebral blood flow but does not aggravate the impact of diet-induced obesity on memory
Kimura_2024_J.Lipid.Res_65_100532 Quantification of lipoprotein lipase in mouse plasma with a sandwich enzyme-linked immunosorbent assay
Leidmaa_2024_Cannabis.Cannabinoid.Res__ Astrocytic Dagla Deletion Decreases Hedonic Feeding in Female Mice
Chen_2024_mSphere__e0006124 Uncovering the roles of Mycobacterium tuberculosis melH in redox and bioenergetic homeostasis: implications for antitubercular therapy
Zolfaghari_2024_Insects_15_ Resistance Mechanism of Plutella xylostella (L.) Associated with Amino Acid Substitutions in Acetylcholinesterase-1: Insights from Homology Modeling, Docking and Molecular Dynamic Simulation
He_2024_bioRxiv__ Molecular basis for the transcriptional regulation of an epoxide-based virulence circuit in Pseudomonas aeruginosa
Nazir_2024_Int.J.Biol.Macromol__129345 Recombinant production and characterization of a metal ion-independent Lysophospholipase from a hyperthermophilic archaeon Pyrococcus abyssi DSM25543
Meinert_2024_Angew.Chem.Int.Ed.Engl__e202405152 Efficient Enzymatic Synthesis of Carbamates in Water Using Promiscuous Esterases\/Acyltransferases
Khoshnevisan_2024_Biochem.Biophys.Rep_37_101617 Uncovering the role of sorbitol in Renilla luciferase kinetics: Insights from spectroscopic and molecular dynamics studies
Lin_2024_Plant.Cell.Rep_43_138 GmSABP2-1 encodes methyl salicylate esterase and functions in soybean defense against soybean cyst nematode
Wang_2024_Toxins.(Basel)_16_3 Comparison Study of Two Fumonisin-Degrading Enzymes for Detoxification in Piglets
Jo_2024_J.Am.Chem.Soc__ Development of Oxadiazolone Activity-Based Probes Targeting FphE for Specific Detection of Staphylococcus aureus Infections
Joel_2024_Int.J.Mol.Sci_25_1272 Role of the C-Terminal beta Sandwich of Thermoanaerobacter tengcongensis Thermophilic Esterase in Hydrolysis of Long-Chain Acyl Substrates
Watanabe_2024_Autophagy__1 The activation mechanism of Atg15, a vacuolar phospholipase required for the disintegration of organelle membranes
Deng_2024_Angew.Chem.Int.Ed.Engl__e202402010 A Versatile Thioesterase Involved in Dimerizationduring Cinnamoyl Lipid Biosynthesis
Cominelli_2024_Pest.Manag.Sci__ Survey of target site mutations linked with insecticide resistance in Italian populations of Aphis gossypii
Shang_2024_Sci.Rep_14_10952 In vitro and in vivo stability of a highly efficient long-acting cocaine hydrolase
Tokunaga_2024_Cureus_16_e53153 The First-Known Case of Hereditary Heterozygous Butyrylcholinesterase Deficiency in a Patient on Dialysis
Chen_2024_Eur.J.Med.Chem_272_116463 Discovery of 4-benzylpiperazinequinoline BChE inhibitor that suppresses neuroinflammation for the treatment of Alzheimer's disease
Dhiman_2024_J.Biomol.Struct.Dyn__1 Discovery of thiazolidinedione-based pancreatic lipase inhibitors as anti-obesity agents: synthesis, in silico studies and pharmacological investigations
Nandi_2024_Pharm.Dev.Technol__1 Lipid-Gelucire based rectal delivery of ramipril prodrug exhibits significant lowering of intra-ocular pressure in normotensive rabbit: Sustained structural relaxation release kinetics and IVIVC
Waiker_2024_Eur.J.Med.Chem_271_116409 Design, synthesis, and biological evaluation of some 2-(3-oxo-5,6-diphenyl-1,2,4-triazin-2(3H)-yl)-N-phenylacetamide hybrids as MTDLs for Alzheimer's disease therapy
Zaafar_2024_Int.J.Biol.Macromol__131740 Unleashing new MTDL AChE and BuChE inhibitors as potential anti-AD therapeutic agents: In vitro, in vivo and in silico studies
Krieger_2024_ACS.Infect.Dis__ Inhibitors of the Thioesterase Activity of Mycobacterium tuberculosis Pks13 Discovered Using DNA-Encoded Chemical Library Screening
Guo_2024_Diabetes.Obes.Metab__ Retagliptin as add-on therapy to metformin in Chinese patients with type 2 diabetes inadequately controlled with metformin: A multicentre, randomized, double-blind, placebo-controlled, phase 3 trial
Wang_2024_Diabetes.Obes.Metab__ Combination of retagliptin and henagliflozin as add-on therapy to metformin in patients with type 2 diabetes inadequately controlled with metformin: A multicentre, randomized, double-blind, active-controlled, phase 3 trial
Anika_2024_Int.Immunopharmacol_129_111639 Neuroprotective effects of Embelin in an ethidium bromide-induced multiple sclerosis in rats: Modulation of p38 MAPK signaling pathway
Goal_2024_Curr.Res.Neurobiol_6_100122 Protective effects of Embelin in Benzo[alpha]pyrene induced cognitive and memory impairment in experimental model of mice
Chayah_2024_Drug.Des.Devel.Ther_18_1133 Synthesis and Anti-Diabetic Activity of an 8-Purine Derivative as a Novel DPP-4 Inhibitor in Obese Diabetic Zucker Rats
Clay_2024_Chem.Res.Toxicol__ Treatment of Organophosphorus Poisoning with 6-Alkoxypyridin-3-ol Quinone Methide Precursors: Resurrection of Methylphosphonate-Aged Acetylcholinesterase
Zhang_2024_Results.Chem_7_101492 Synthesis and evaluation of a highly selective cannabidiol amide cholinesterase inhibitor
Samarelli_2024_Eur.J.Med.Chem_270_116353 Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino[4,3-b]indol-1(2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults
Kuzu_2024_Mol.Divers__ Structure-based inhibition of acetylcholinesterase and butyrylcholinesterase with 2-Aryl-6-carboxamide benzoxazole derivatives: synthesis, enzymatic assay, and in silico studies
Wang_2024_J.Med.Chem__ Butyrylcholinesterase-Activated Near-Infrared Fluorogenic Probe for In Vivo Theranostics of Alzheimer's Disease
Chen_2024_J.Med.Chem__ Design and Synthesis of Dual-Targeting Inhibitors of sEH and HDAC6 for the Treatment of Neuropathic Pain and Lipopolysaccharide-Induced Mortality
Petrova_2024_Chem.Biol.Drug.Des_103_e14506 Diethoxyphosphoryloxy-oleanolic acid is a nanomolar-inhibitor of butyrylcholinesterase
Shariatzadeh_2024_ACS.Appl.Bio.Mater_12_45859 Ultrasensitive Nanofiber Biosensor: Rapid In Situ Chromatic Detection of Bacteria for Healthcare Innovation
Gorecki_2024_Chem.Biol.Interact__110941 Uncharged mono- and bisoximes: In search of a zwitterion to countermeasure organophosphorus intoxication
Schmalhofer_2024_Adv.Sci.(Weinh)__e2400184 Polyketide Trimming Shapes Dihydroxynaphthalene-Melanin and Anthraquinone Pigments
Michalska_2024_ACS.Chem.Neurosci__ 4-Oxypiperidine Ethers as Multiple Targeting Ligands at Histamine H(3) Receptors and Cholinesterases
Jevtic_2024_Bioorg.Med.Chem_101_117649 Multi-target potential of newly designed tacrine-derived cholinesterase inhibitors: Synthesis, computational and pharmacological study
El Ati_2024_Arch.Pharm.(Weinheim)__e2300545 Novel benzene sulfonamides with acetylcholinesterase and carbonic anhydrase inhibitory actions
Trancart_2024_Chem.Biol.Interact__110929 No-observed-adverse-effect-level (NOAEL) assessment as an optimized dose of cholinesterase reactivators for the treatment of exposure to warfare nerve agents in mice
Funahashi_2024_Bioorg.Chem_145_107229 Hybrid pharmacophore design and synthesis of donepezil-inspired aurone derivative salts as multifunctional acetylcholinesterase inhibitors
Li_2024_Chirality_36_e23643 Resolution of N-acetyl-DL-methionine methyl ester by the lipase from Brucella thiophenivorans
Mugnaini_2024_ACS.Chem.Neurosci__ Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo
Dinh Thanh_2024_Arch.Pharm.(Weinheim)__e2300557 Sulfonyl thioureas with a benzo[d]thiazole ring as dual acetylcholinesterase\/butyrylcholinesterase and human monoamine oxidase A and B inhibitors: An in vitro and in silico study
Zhai_2024_Arch.Pharm.(Weinheim)__e2300693 Design, synthesis, and evaluation of dual-target inhibitors for the treatment of Alzheimer's disease
Liu_2024_Eur.J.Med.Chem__116169 Corrigendum to Design, synthesis and biological evaluation of carbamate derivatives incorporating multifunctional carrier scaffolds as pseudo-irreversible cholinesterase inhibitors for the treatment of Alzheimer's disease [Eur. J. Med. Chem. 265 (2024) 116071]
Fonseca_2024_Biomimetics.(Basel)_9_ One-Step Purification of Recombinant Cutinase from an E. coli Extract Using a Stabilizing Triazine-Scaffolded Synthetic Affinity Ligand
Wang_2024_J.Agric.Food.Chem__ Carboxylesterase and Cytochrome P450 Confer Metabolic Resistance Simultaneously to Azoxystrobin and Some Other Fungicides in Botrytis cinerea
Huang_2024_Drug.Des.Devel.Ther_18_133 In vitro and in vivo Biological Evaluation of Newly Tacrine-Selegiline Hybrids as Multi-Target Inhibitors of Cholinesterases and Monoamine Oxidases for Alzheimer's Disease
Rosse_2024_ACS.Med.Chem.Lett_15_19 Novel Pyrazolopyridine Inhibitors of Monoacylglycerol Lipase for the Treatment of Neurodegenerative Diseases and Neuroinflammation
Gupta_2024_Sci.Rep_14_1687 Investigation, scaffold hopping of novel donepezil-based compounds as anti-Alzhiemer's agents: synthesis, in-silico and pharmacological evaluations
Makhaeva_2024_Molecules_29_321 Combining Experimental and Computational Methods to Produce Conjugates of Anticholinesterase and Antioxidant Pharmacophores with Linker Chemistries Affecting Biological Activities Related to Treatment of Alzheimer's Disease
Jiang_2024_J.Mater.Chem.B__ Carboxylesterase-activated near-infrared fluorescence probe for highly sensitive imaging of liver tumors
Smolak_2024_J.Pharmacol.Exp.Ther__ Target cell activation of a structurally novel NLRP3 inhibitor NT-0796 enhances potency
Misiachna_2024_Eur.J.Med.Chem_266_116130 Phenoxytacrine derivatives: Low-toxicity neuroprotectants exerting affinity to ifenprodil-binding site and cholinesterase inhibition
Banoo_2024_Eur.J.Med.Chem_266_116131 Design, synthesis, and pharmacological evaluation of indole-piperidine amides as Blood-brain barrier permeable dual cholinesterase and beta-secretase inhibitors
Tobuse_2024_Med.Chem.Res_33_298 Indazole derivatives as selective inhibitors of butyrylcholinesterase with effective blood-brain-barrier permeability profile
Sato_2024_J.Oleo.Sci_73_55 Regiospecificity of Immobilized Candida antarctica Lipase B (CAL-B) towards 2,3-Diacyl-1-O-alkyl Glyceryl Ether in Ethanol
Mezeiova_2024_Biomed.Pharmacother_173_116399 Morphing cholinesterase inhibitor amiridine into multipotent drugs for the treatment of Alzheimer's disease
Shi_2024_Clin.Pharmacokinet__ Pharmacokinetics, Pharmacodynamics, and Safety of Single Dose HSK7653 Tablets in Chinese Subjects with Normal or Impaired Renal Function
Zhu_2024_Int.J.Biol.Macromol_259_129117 AChE activity self-breathing control mechanisms regulated by H(2)S(n) and GSH: Persulfidation and glutathionylation on sulfhydryl after disulfide bonds cleavage
Pidany_2024_RSC.Med.Chem__ Carltonine-Derived Compounds for Targeted Butyrylcholinesterase Inhibition
Wang_2024_Anal.Chem__ New Near-Infrared Fluorescence Imaging Platform with Large Stokes Shift for Carboxylesterase 2 Detection in Thyroid Cancer and Inflammatory Diseases Diagnosis
Karaboga_2024_J.Hazard.Mater_470_134236 Organophosphate toxicity patterns: A new approach for assessing organophosphate neurotoxicity
Xing_2024_Eur.J.Med.Chem_268_116289 Optimizing drug-like properties of selective butyrylcholinesterase inhibitors for cognitive improvement: Enhancing aqueous solubility by disrupting molecular plane
Schmalix_2024_Curr.Drug.Metab__ The Metabolism of the New Benzodiazepine Remimazolam
Zhou_2024_Expert.Opin.Investig.Drugs_33_9 Bemnifosbuvir (BEM, AT-527), a novel nucleotide analogue inhibitor of the hepatitis C virus NS5B polymerase
Coggins_2024_Vet.Q_44_1 Assessing in vitro stability of remdesivir (GS-5734) and conversion to GS-441524 in feline plasma and whole blood
Yu_2024_J.Enzyme.Inhib.Med.Chem_39_2313682 Novel anti-neuroinflammatory pyranone-carbamate derivatives as selective butyrylcholinesterase inhibitors for treating Alzheimer's disease
Li_2024_Environ.Toxicol.Pharmacol__104423 Biotoxicity responses of Zebrafish in environmentally relevant concentration of Di (2-ethylhexyl) phthalate
Lovins_2024_ACS.Chem.Neurosci__ 4-Amidophenol Quinone Methide Precursors: Effective and Broad-Scope Nonoxime Reactivators of Organophosphorus-Inhibited Cholinesterases and Resurrectors of Organophosphorus-Aged Acetylcholinesterase
Bah_2024_Prostaglandins.Other.Lipid.Mediat__106850 Soluble Epoxide Hydrolase Inhibition Reverses Cognitive Dysfunction in a Mouse Model of Metabolic Syndrome by Modulating Inflammation
Lee_2024_Biochem.Biophys.Rep_38_101673 Gemigliptin, a potent selective dipeptidyl peptidase 4 inhibitor, protects endothelial progenitor cells by oxidative stress via caspase-3 dependent pathway
Mican_2024_Appl.Catal.B.Environmental_342_123404 Exploring new galaxies: Perspectives on the discovery of novel PET-degrading enzymes
Aryal_2024_Pharm.Res__ Stress-mediated polysorbate 20 degradation and its potential impact on therapeutic proteins
Diester_2024_J.Pharmacol.Exp.Ther__ Effects of Repeated Treatment with the Monoacylglycerol Lipase Inhibitor MJN110 on Pain-Related Depression of Nesting and Cannabinoid 1 Receptor Function in Male and Female Mice
Cho_2024_Neurourol.Urodyn__ Improvement of lower urinary tract dysfunction by a monoacylglycerol lipase inhibitor in mice with spinal cord injury
Kelly_2024_Proc.Natl.Acad.Sci.U.S.A_121_e2314085121 Enhancing cancer immunotherapy via inhibition of soluble epoxide hydrolase
Dey_2024_J.Pharm.Biomed.Anal_244_116116 Identification and characterization of the in-vivo metabolites of the novel soluble epoxide hydrolase inhibitor EC5026 using liquid chromatography quadrupole time of flight mass spectrometry
Park_2024_BMJ.Open_14_e077084 Cardiovascular safety of evogliptin dual and triple therapy in patients with type 2 diabetes: a nationwide cohort study
Espadinha_2024_Eur.J.Med.Chem_270_116389 Active site-directed probes targeting dipeptidyl peptidases 8 and 9
Nagayama_2024_J.Clin.Med_13_ Effects of Vildagliptin, a Dipeptidyl Peptidase-4 Inhibitor, on the Parameters of Glucose Metabolism and the Cardio-Ankle Vascular Index in Individuals with Type 2 Diabetes
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Cybulski_2024_RSC.Adv_14_13129 The conjugates of 5'-deoxy-5-fluorocytidine and hydroxycinnamic acids - synthesis, anti-pancreatic cancer activity and molecular docking studies
Dagli-Hernandez_2024_Pharmacogenet.Genomics_34_91 Predicted deleterious variants in ABCA1, LPL, LPA and KIF6 are associated with statin response and adverse events in patients with familial hypercholesterolemia and disturb protein structure and stability
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Defant_2024_Mar.Drugs_22_ Structural Insights into the Marine Alkaloid Discorhabdin G as a Scaffold towards New Acetylcholinesterase Inhibitors
Dessai_2024_Cureus_16_e57260 The Rise of Remimazolam: A Review of Pharmacology, Clinical Efficacy, and Safety Profiles
Edin_2024_Biochem.Pharmacol__116237 Overexpression of soluble epoxide hydrolase reduces post-ischemic recovery of cardiac contractile function
Elmansoury_2024_Genes.(Basel)_15_ Relevance of PNPLA3, TM6SF2, HSD17B13, and GCKR Variants to MASLD Severity in an Egyptian Population
Esmaeily_2024_Sci.Rep_14_9766 Four phospholipase A(2) genes encoded in the western flower thrips genome and their functional differentiation in mediating development and immunity
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Foroughi_2024_Brain.Res__148966 Investigating the effects of Thymus vulgaris essential oil, Allium cepa extract, and their active compounds (thymol and quercetin) on expression profile of genes related to Alzheimer's disease in PC12 model cell
Fratianni_2024_Antioxidants.(Basel)_13_ Chemical Characterization and Biological Properties of Leguminous Honey
Giancola_2024_ACS.Chem.Biol_19_908 Evaluation of the Cytosolic Uptake of HaloTag Using a pH-Sensitive Dye
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