human-NDRG2

 
Homo sapiens (Human) ndrg2 protein N-myc downstream-regulated gene 2 protein (syld709613 protein) ndr1-related protein 2

Comment
Q96FD3 Q96JU0 Q96FT0 Q86U46 Q86U08 probable alternative splicing. Q8TDR6 very close


Relationship
Family Ndr_family
Block X
Homo sapiens position in NCBI Life Tree :
N link to NCBI taxonomic web page and E link to ESTHER gene locus found in this strain.
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Mammalia: N E > Theria: N E > Eutheria: N E > Boreoeutheria: N E > Euarchontoglires: N E > Primates: N E > Haplorrhini: N E > Simiiformes: N E > Catarrhini: N E > Hominoidea: N E > Hominidae: N E > Homininae: N E > Homo: N E > Homo sapiens: N E

Molecular evidence
Database
No mutation
3 structures: 2XMQ, 2XMR, 2XMS
No kinetic



>3 Genbank links 11 more: AF304051, CR749252, BC093038
>3 UniProt links 40 more: Q8TDR6, Q9UN36, H0YJ56
3 Structure : 2XMQ, 2XMR, 2XMS
>3 UniProtTrembl links 40 more: Q8TDR6, Q9UN36, H0YJ56
>3 Interpro links 40 more: Q8TDR6, Q9UN36, H0YJ56
>3 Prodom links 40 more: Q8TDR6, Q9UN36, H0YJ56
>3 Pfam links 40 more: Q8TDR6, Q9UN36, H0YJ56
>3 PIRSF links 40 more: Q8TDR6, Q9UN36, H0YJ56
>3 SUPERFAM links 40 more: Q8TDR6, Q9UN36, H0YJ56
>3 QuickSwissBlast links 40 more: Q8TDR6, Q9UN36, H0YJ56
1 EntrezGene : 57447
1 SNP : 57447
1 UniGene : 525205
1 HUGO HGNC : 14460
1 OMIM : 605272
1 Ensembl : ENSG00000165795
 
Sequence
Graphical view for this peptide sequence: human-NDRG2
Colored MSA for Ndr_family (raw)
MAELQEVQITEEKPLLPGQTPEAAKEAELAARILLDQGQTHSVETPYGSV
TFTAYGTPKPKRPAILTYHDVGLNYKSCFQPLFQFEDMQEIIQNFVRVHV
DAPGMEEGAPVFPLGYQYPSLDQLADMIPCVLQYLNFSTIIGVGVGAGAY
ILARYALNHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSIPEMILGH
LFSQEELSGNSELIQKYRNIITHAPNLDNIELYWNSYNNRRDLNFERGGN
ITLRCPVMLVVGDQAPHEDAVVECNSKLDPTQTSFLKMADSGGQPQLTQP
GKLTEVFKYFLQGMGYMASSCMTRLSRSRTASLTSAASVDGNRSRSRTLS
QSSESGTLSSGPPGHTMEVSC
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MAELQEVQITEEKPLLPGQTPEAAKEAELAARILLDQGQTHSVETPYGSV
TFTAYGTPKPKRPAILTYHDVGLNYKSCFQPLFQFEDMQEIIQNFVRVHV
DAPGMEEGAPVFPLGYQYPSLDQLADMIPCVLQYLNFSTIIGVGVGAGAY
ILARYALNHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSIPEMILGH
LFSQEELSGNSELIQKYRNIITHAPNLDNIELYWNSYNNRRDLNFERGGN
ITLRCPVMLVVGDQAPHEDAVVECNSKLDPTQTSFLKMADSGGQPQLTQP
GKLTEVFKYFLQGMGYMASSCMTRLSRSRTASLTSAASVDGNRSRSRTLS
QSSESGTLSSGPPGHTMEVSC

no DNA




References
10 more
    Title: Roles of N-myc downstream-regulated gene 2 in the central nervous system: molecular basis and relevance to pathophysiology
    Takarada-Iemata M
    Ref: Anat Sci Int, 96:1, 2021 : PubMed

            

    Title: Astrocyte-specific NDRG2 gene: functions in the brain and neurological diseases
    Li X, Wu X, Luo P, Xiong L
    Ref: Cell Mol Life Sciences, 77:2461, 2020 : PubMed

            

    Title: Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family
    Qu X, Zhai Y, Wei H, Zhang C, Xing G, Yu Y, He F
    Ref: Molecular & Cellular Biochemistry, 229:35, 2002 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
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