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Family Report for: abh_upf0017


Block X
Parent Family : Hydrolase_4

This family includes: Escherichia coli yheT (Zhang et al. 1998); Yeast YBR177c (octanoyl-CoA:ethanol acyltransferase thioesterase), YMR210w, YPL095c; Mammalian ABHD1/2/3/15 are included. Human protein ABHD1, ABHD2 (pHPS1-2), ABHD3, ABHD15 (an essential component in the development of adipocytes as well as in apoptosis Walenta et al. 2013) Human ABHD3 is a phospholipase that may play a role in phospholipids remodeling. It may selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position; Enhanced neointimal hyperplasia was observed in Abhd2-deficient mice, using an experimental vascular cuff placement injury model. Abhd2 is expressed in vascular smooth muscle cells (SMCs). An association between the human ABHD2 gene and colorectal cancer and with Risks for Chronic Obstructive Pulmonary Diseaseis reported. ABHD2 is involved in virus propagation, immune response, and fertilization namely in the P4-stimulated acrosome reaction. Monoacylglycerol lipase ABHD2 is a steroid-activated (progesterone P4) enzyme that hydrolyzes 2-arachidonoylglycerol. ABHD2 is expressed in sperm and in ovaries. ABHD2 regulates the rhythm of follicular maturation and estrous stages of the female reproductive cycle (Bjorkgren et al.) The family also contains: Drosophila protein ABHD2 anon-23D; Picea glauca (white spruce) late embryogenesis abundant protein EMB8 (Dong et al. 1999); and Caenorhabditis elegans C44C1.5. (UPF0017_hydro-like_CS abh_upf0017 IPR000952 (conserved site) is included in IPR012020 Hydrolase_YheT in Interpro. ABHD15 does not have a serine in the position of the catalytic triad. TAMRA-FP probe does not interact with ABHD15. ABHD15 has no hydrolase activity. (These entries where previously included in AlphaBeta_hydrolase family in ESTHER). Main substrates include: ABHD2 triacylglycerols, esters; ABHD3 medium-chain phospholipids, phosphatidylcholines containing C14 acyl chain, oxidatively truncated phospholipids

IPR000952 (Uncharacterised protein family UPF0017, hydrolase-like, conserved site), IPR012020 (AB hydrolase 4 family, AB-hydrolase YheT, putative ABHD4), IPR000952 (UPF0017_hydro-like_CS)
no EC number

Peptide in
Nucleotide in
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
|Graphical display, obtained with the dnd file produced by Clustalw

21 more
    Title: Lipidomic QTL in Diversity Outbred mice identifies a novel function for alpha/beta hydrolase domain 2 (Abhd2) as an enzyme that metabolizes phosphatidylcholine and cardiolipin
    Price TR, Stapleton DS, Schueler KL, Norris MK, Parks BW, Yandell BS, Churchill GA, Holland WL, Keller MP, Attie AD
    Ref: Biorxiv, :, 2023 : PubMed


    Title: Regulation of the sperm calcium channel CatSper by endogenous steroids and plant triterpenoids
    Mannowetz N, Miller MR, Lishko PV
    Ref: Proc Natl Acad Sci U S A, 114:5743, 2017 : PubMed


    Title: Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone
    Miller MR, Mannowetz N, Iavarone AT, Safavi R, Gracheva EO, Smith JF, Hill RZ, Bautista DM, Kirichok Y, Lishko PV
    Ref: Science, 352:555, 2016 : PubMed


Other Papers

No structure scheme yet for this family

No Structure yet in this family

Genes Proteins in abh_upf0017 family (730)

Fragments of genes in abh_upf0017 family (50)

Substrates of some enzymes in the abh_upf0017 family (9)

Inhibitors of some enzymes in the abh_upf0017 family (5)

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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