human-AADAC

 
Homo sapiens (Human) arylacetamide deacetylase

Comment
Arylacetamide deacetylase displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity


Relationship
Block H
Homo sapiens position in NCBI Life Tree :
N link to NCBI taxonomic web page and E link to ESTHER gene locus found in this strain.
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Mammalia: N E > Theria: N E > Eutheria: N E > Boreoeutheria: N E > Euarchontoglires: N E > Primates: N E > Haplorrhini: N E > Simiiformes: N E > Catarrhini: N E > Hominoidea: N E > Hominidae: N E > Homininae: N E > Homo: N E > Homo sapiens: N E

Molecular evidence
Database
No mutation
No structure
No kinetic

Substrate: Rifampicin , Prasugrel , Eslicarbazepine-acetate , Flutamide , Phenacetin , Vicagrel ,
Inhibitor: Epicatechin-gallate , Epigallocatechin-gallate , Vinblastine ,
3 Genbank : L32179, CH471052, AC068647
2 UniProt : P22760, C9K0E9
1 Ncbi-nid : 537513 1703031
2 UniProtTrembl : P22760, C9K0E9
2 Interpro : P22760, C9K0E9
2 Prodom : P22760, C9K0E9
2 Pfam : P22760, C9K0E9
2 PIRSF : P22760, C9K0E9
2 SUPERFAM : P22760, C9K0E9
2 QuickSwissBlast : P22760, C9K0E9
1 EntrezGene : 13
1 SNP : 13
1 UniGene : 506908
1 HUGO HGNC : 17
1 OMIM : 600338
1 Ensembl : ENSG00000114771
 
Sequence
Graphical view for this peptide sequence: human-AADAC
Colored MSA for Arylacetamide_deacetylase (raw)
MGRKSLYLLIVGILIAYYIYTPLPDNVEEPWRMMWINAHLKTIQNLATFV
ELHGSSIFMDSFKVVGSFDEVPPTSDENVTVTETKFNNILVRVYVPKRKS
EALRRGLFYIHGGGWCVGSAALSGYDLLSRWTADRLDAVVVSTNYRLAPK
YHFPIQFEDVYNALRWFLRKKVLAKYGVNPERIGISGDSAGGNLAAAVTQ
QLLDDPDVKIKLKIQSLIYPALQPLDVDLPSYQENSNFLFLSKSLMVRFW
SEYFTTDRSLEKAMLSRQHVPVESSHLFKFINWSSLLPERFIKGHVYNNP
NYGSSELAKKYPGFLDVRAAPLLADDNKLRGLPLTYVITCQYDLLRDDGL
MYVTRLRNTGVQVTHNHVEDGFHGAFSFLGLKISHRLINQYIEWLKENL
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MGRKSLYLLIVGILIAYYIYTPLPDNVEEPWRMMWINAHLKTIQNLATFV
ELHGSSIFMDSFKVVGSFDEVPPTSDENVTVTETKFNNILVRVYVPKRKS
EALRRGLFYIHGGGWCVGSAALSGYDLLSRWTADRLDAVVVSTNYRLAPK
YHFPIQFEDVYNALRWFLRKKVLAKYGVNPERIGISGDSAGGNLAAAVTQ
QLLDDPDVKIKLKIQSLIYPALQPLDVDLPSYQENSNFLFLSKSLMVRFW
SEYFTTDRSLEKAMLSRQHVPVESSHLFKFINWSSLLPERFIKGHVYNNP
NYGSSELAKKYPGFLDVRAAPLLADDNKLRGLPLTYVITCQYDLLRDDGL
MYVTRLRNTGVQVTHNHVEDGFHGAFSFLGLKISHRLINQYIEWLKENL

Graphical view for this nucleotide DNA sequence (1644 bp): human-AADAC



References
11 more
    Title: Impact of AADAC gene expression on prognosis in patients with Borrmann type III advanced gastric cancer
    Wang Y, Fang T, Yin X, Zhang L, Zhang X, Zhang D, Zhang Y, Wang X, Wang H, Xue Y
    Ref: BMC Cancer, 22:635, 2022 : PubMed

            

    Title: Screening of specific inhibitors for human carboxylesterases or arylacetamide deacetylase
    Shimizu M, Fukami T, Nakajima M, Yokoi T
    Ref: Drug Metabolism & Disposition: The Biological Fate of Chemicals, 42:1103, 2014 : PubMed

            

    Title: Arylacetamide deacetylase: a novel host factor with important roles in the lipolysis of cellular triacylglycerol stores, VLDL assembly and HCV production
    Nourbakhsh M, Douglas DN, Pu CH, Lewis JT, Kawahara T, Lisboa LF, Wei E, Asthana S, Quiroga AD and Kneteman NM <6 more author(s)>
    Ref: Journal of Hepatology, 59:336, 2013 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
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