human-CES2

 
Homo sapiens (Human) carboxylesterase hCE-2,iCE, hiCE, CES2 gene cDNA FLJ76104 Cocaine esterase

Comment
human carboxylesterase iCE gene intestine and liver, Q8IUP4 (Strausberg R.) contains 65 extra amino acid in N-term


Relationship
Block C
Homo sapiens position in NCBI Life Tree :
N link to NCBI taxonomic web page and E link to ESTHER gene locus found in this strain.
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Mammalia: N E > Theria: N E > Eutheria: N E > Boreoeutheria: N E > Euarchontoglires: N E > Primates: N E > Haplorrhini: N E > Simiiformes: N E > Catarrhini: N E > Hominoidea: N E > Hominidae: N E > Homininae: N E > Homo: N E > Homo sapiens: N E

Molecular evidence
Database
>3 Genbank links 11 more: AK222724, U60553, D50579
>3 UniProt links 2 more: O00748, Q4G0E9, J3QLP1
3 Ncbi-nid : 1407780, NP_003860, 2058317
3 Ncbi-pid : XP_007873, XP_012498, 2058318
>3 UniProtTrembl links 4 more: Q53H57, O00748, Q6IPK9
>3 Interpro links 4 more: Q53H57, O00748, Q6IPK9
>3 Prodom links 4 more: Q53H57, O00748, Q6IPK9
>3 Pfam links 4 more: Q53H57, O00748, Q6IPK9
>3 PIRSF links 4 more: Q53H57, O00748, Q6IPK9
>3 SUPERFAM links 4 more: Q53H57, O00748, Q6IPK9
>3 QuickSwissBlast links 4 more: Q53H57, O00748, Q6IPK9
1 EntrezGene : 8824
1 SNP : 8824
1 UniGene : 282975
1 HUGO HGNC : 1864
1 OMIM : 605278
1 Ensembl : ENSG00000172831
 
Sequence
Graphical view for this peptide sequence: human-CES2
Colored MSA for Carb_B_Chordata (raw)
MRLHRLRARLSAVACGLLLLLVRGQGQDSASPIRTTHTGQVLGSLVHVKG
ANAGVQTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLT
AVESEFLSQFNMTFPSDSMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGA
LVFGMASLYDGSMLAALENVVVVIIQYRLGVLGFFSTGDKHATGNWGYLD
QVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPISQGLFHGA
IMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKSKEEI
LAINKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLI
PKVMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDP
QTLQAQFQEMMADSMFVIPALQVAHFQCSRAPVYFYEFQHQPSWLKNIRP
PHMKADHGDELPFVFRSFFGGNYIKFTEEEEQLSRKMMKYWANFARNGNP
NGEGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWKKALPQKIQELE
EPEERHTEL
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MRLHRLRARLSAVACGLLLLLVRGQGQDSASPIRTTHTGQVLGSLVHVKG
ANAGVQTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLT
AVESEFLSQFNMTFPSDSMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGA
LVFGMASLYDGSMLAALENVVVVIIQYRLGVLGFFSTGDKHATGNWGYLD
QVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPISQGLFHGA
IMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKSKEEI
LAINKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLI
PKVMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDP
QTLQAQFQEMMADSMFVIPALQVAHFQCSRAPVYFYEFQHQPSWLKNIRP
PHMKADHGDELPFVFRSFFGGNYIKFTEEEEQLSRKMMKYWANFARNGNP
NGEGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWKKALPQKIQELE
EPEERHTEL

Graphical view for this nucleotide DNA sequence (1795 bp): human-CES2



References
25 more
    Title: Carboxylesterase 2 proteins are efficient diglyceride and monoglyceride lipases possibly implicated in metabolic disease
    Chalhoub G, Kolleritsch S, Maresch LK, Taschler U, Pajed L, Tilp A, Natmessnig H, Rosina P, Kien B and Haemmerle G <4 more author(s)>
    Ref: J Lipid Res, :100075, 2021 : PubMed

            

    Title: Overexpressed CES2 has prognostic value in CRC and knockdown CES2 reverses L-OHP-resistance in CRC cells by inhibition of the PI3K signaling pathway
    Zhang Y, Sun L, Sun Y, Chen Y, Wang X, Xu M, Chi P, Xu Z, Lu X
    Ref: Experimental Cell Research, :111856, 2020 : PubMed

            

    Title: Prognostic Impact of Carboxylesterase 2 in Cholangiocarcinoma
    Goeppert B, Renner M, Singer S, Albrecht T, Zhang Q, Mehrabi A, Pathil A, Springfeld C, Kohler B and Utku N <8 more author(s)>
    Ref: Sci Rep, 9:4338, 2019 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
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