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Author Report for: Brazzolotto X

Contact information:

Brazzolotto Xavier
Institut de Recherche Biomedicale des Armees, 91223 Bretigny sur Orge
France
Phone : +33476639738
Fax :
Send E-Mail to Brazzolotto Xavier





    Title: 8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases
    Knez D, Diez-Iriepa D, Chioua M, Gottinger A, Denic M, Chantegreil F, Nachon F, Brazzolotto X, Skrzypczak-Wiercioch A and Marco-Contelle J <13 more author(s)>
    Ref: Acta Pharmaceutica Sinica B, :, 2023 : PubMed

            

    Title: Discovery of new, highly potent and selective inhibitors of BuChE - Design, synthesis, in vitro and in vivo evaluation and crystallography studies
    Panek D, Pasieka A, Latacz G, Zareba P, Szczech M, Godyn J, Chantegreil F, Nachon F, Brazzolotto X and Malawska B <7 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, :115135, 2023 : PubMed

            

    Title: From tryptophan-based amides to tertiary amines: Optimization of a butyrylcholinesterase inhibitor series
    Meden A, Knez D, Brazzolotto X, Nachon F, Dias J, Svete J, Stojan J, Groselj U, Gobec S
    Ref: Eur Journal of Medicinal Chemistry, 230:114248, 2022 : PubMed

            

    Title: Pseudo-irreversible butyrylcholinesterase inhibitors: SAR, kinetic, computational, and crystallographic study of the N-dialkyl O-arylcarbamate warhead
    Meden A, Knez D, Brazzolotto X, Modeste F, Perdih A, Pislar A, Zorman M, Denic M, Pajk S and Gobec S <1 more author(s)>
    Ref: Chemrxiv, :, 2022 : PubMed

            

    Title: Pseudo-irreversible butyrylcholinesterase inhibitors: Structure-activity relationships, computational and crystallographic study of the N-dialkyl O-arylcarbamate warhead
    Meden A, Knez D, Brazzolotto X, Modeste F, Perdih A, Pislar A, Zorman M, Zorovic M, Denic M and Gobec S <3 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 247:115048, 2022 : PubMed

            

    Title: Grid-type Quaternary Metallosupramolecular Compounds Inhibit Human Cholinesterases through Dynamic Multivalent Interactions
    Nachon F, Brazzolotto X, Dias J, Courageux C, Drozdz W, Cao XY, Stefankiewicz AR, Lehn JM
    Ref: Chembiochem, :, 2022 : PubMed

            

    Title: Characterization of four BCHE mutations associated with prolonged effect of suxamethonium
    Brazzolotto X, Courcelle S, Sauvanet C, Guillon V, Igert A, Kononchik J, Nachon F, Ceppa F, Delacour H
    Ref: Pharmacogenomics J, 21(2):165-173:, 2021 : PubMed

            

    Title: A Thermophilic Bacterial Esterase for Scavenging Nerve Agents: A Kinetic, Biophysical and Structural Study
    Bzdrenga J, Trenet E, Chantegreil F, Bernal K, Nachon F, Brazzolotto X
    Ref: Molecules, 26:657, 2021 : PubMed

            

    Title: Fine-Tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidants for Neurodegenerative Diseases
    Chavarria D, Da Silva O, Benfeito S, Barreiro S, Garrido J, Cagide F, Soares P, Remiao F, Brazzolotto X and Borges F <3 more author(s)>
    Ref: Antioxidants (Basel), 10:, 2021 : PubMed

            

    Title: Diisopropylfluorophosphate-induced status epilepticus drives complex glial cell phenotypes in adult male mice
    Maupu C, Enderlin J, Igert A, Oger M, Auvin S, Hassan-Abdi R, Soussi-Yanicostas N, Brazzolotto X, Nachon F and Dupuis N <1 more author(s)>
    Ref: Neurobiol Dis, :105276, 2021 : PubMed

            

    Title: Discovery of drug-like acetylcholinesterase inhibitors by rapid virtual screening of a 6.9 million compound database
    Miles JA, Ng JH, Sreenivas BY, Courageux C, Igert A, Dias J, McGeary RP, Brazzolotto X, Ross BP
    Ref: Chemical Biology Drug Des, :, 2021 : PubMed

            

    Title: Discovery of multifunctional anti-Alzheimers agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and gamma-aminobutyric acid transporters
    Pasieka A, Panek D, Jonczyk J, Godyn J, Szalaj N, Latacz G, Tabor J, Mezeiova E, Chantegreil F and Malawska B <10 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 218:113397,  : PubMed

            

    Title: Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice
    Viayna E, Coquelle N, Cieslikiewicz-Bouet M, Cisternas P, Oliva CA, Sanchez-Lopez E, Ettcheto M, Bartolini M, De Simone A and Munoz-Torrero D <16 more author(s)>
    Ref: Journal of Medicinal Chemistry, 64:812, 2021 : PubMed

            

    Title: Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HT(6) receptor with anti-aggregation properties against amyloid-beta and tau
    Wichur T, Pasieka A, Godyn J, Panek D, Goral I, Latacz G, Honkisz-Orzechowska E, Bucki A, Siwek A and Wieckowska A <7 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 225:113783, 2021 : PubMed

            

    Title: Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HT6R antagonists with beta-amyloid anti-aggregation properties
    Wichur T, Godyn J, Goral I, Latacz G, Bucki A, Siwek A, Gluch-Lutwin M, Mordyl B, Sniecikowska J and Wieckowska A <8 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 225:113792, 2021 : PubMed

            

    Title: Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime
    Calas AG, Hanak AS, Jaffre N, Nervo A, Dias J, Rousseau C, Courageux C, Brazzolotto X, Villa P and Nachon F <9 more author(s)>
    Ref: Biomolecules, 10:, 2020 : PubMed

            

    Title: N-alkylpiperidine carbamates as potential anti-Alzheimer's agents
    Kosak U, Strasek N, Knez N, Jukic M, Zakelj S, Zahirovic A, Pislar A, Brazzolotto X, Nachon F and Knez D <2 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 197:112282, 2020 : PubMed

            

    Title: Enantioseparation, in vitro testing, and structural characterization of triple-binding reactivators of organophosphate-inhibited cholinesterases
    Marakovic N, Knezevic A, Roncevic I, Brazzolotto X, Kovarik Z, Sinko G
    Ref: Biochemical Journal, 477:2771, 2020 : PubMed

            

    Title: Structure-activity relationship study of tryptophan-based butyrylcholinesterase inhibitors
    Meden A, Knez D, Malikowska-Racia N, Brazzolotto X, Nachon F, Svete J, Salat K, Groselj U, Gobec S
    Ref: Eur Journal of Medicinal Chemistry, 208:112766, 2020 : PubMed

            

    Title: Rapid discovery of a selective butyrylcholinesterase inhibitor using structure-based virtual screening
    Miles JA, Kapure JS, Singh Deora G, Courageux C, Igert A, Dias J, McGeary RP, Brazzolotto X, Ross BP
    Ref: Bioorganic & Medicinal Chemistry Lett, :127609, 2020 : PubMed

            

    Title: Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes
    Pajk S, Knez D, Kosak U, Zorovic M, Brazzolotto X, Coquelle N, Nachon F, Colletier JP, Zivin M and Gobec S <1 more author(s)>
    Ref: J Enzyme Inhib Med Chem, 35:498, 2020 : PubMed

            

    Title: Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease
    Chalupova K, Korabecny J, Bartolini M, Monti B, Lamba D, Caliandro R, Pesaresi A, Brazzolotto X, Gastellier AJ and Kuca K <25 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 168:491, 2019 : PubMed

            

    Title: An evolutionary perspective on the first disulfide bond in members of the cholinesterase-carboxylesterase (COesterase) family: Possible outcomes for cholinesterase expression in prokaryotes
    Chatonnet A, Brazzolotto X, Hotelier T, Lenfant N, Marchot P, Bourne Y
    Ref: Chemico-Biological Interactions, 308:179, 2019 : PubMed

            

    Title: Rivastigmine and metabolite analogues with putative Alzheimer's disease-modifying properties in a Caenorhabditis elegans model.
    Dighe SN, De la Mora E, Chan S, Kantham S, McColl G, Miles JA, Veliyath SK, Sreenivas BY, Nassar ZD and Ross BP <6 more author(s)>
    Ref: Communications chemistry, 2:35, 2019 : PubMed

            

    Title: Tryptophan-derived butyrylcholinesterase inhibitors as promising leads against Alzheimer's disease
    Meden A, Knez D, Jukic M, Brazzolotto X, Grsic M, Pislar A, Zahirovic A, Kos J, Nachon F and Groselj U <2 more author(s)>
    Ref: Chem Commun (Camb), 55:3765, 2019 : PubMed

            

    Title: X-ray structures of human bile-salt activated lipase conjugated to nerve agents surrogates
    Touvrey C, Courageux C, Guillon V, Terreux R, Nachon F, Brazzolotto X
    Ref: Toxicology, 411:15, 2019 : PubMed

            

    Title: Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities
    Knez D, Coquelle N, Pislar A, Zakelj S, Jukic M, Sova M, Mravljak J, Nachon F, Brazzolotto X and Gobec S <2 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 156:598, 2018 : PubMed

            

    Title: The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity
    Kosak U, Brus B, Knez D, Zakelj S, Trontelj J, Pislar A, Sink R, Jukic M, Zivin M and Gobec S <8 more author(s)>
    Ref: Journal of Medicinal Chemistry, 61:119, 2018 : PubMed

            

    Title: Purification of recombinant human butyrylcholinesterase on Hupresin(R)
    Lockridge O, David E, Schopfer LM, Masson P, Brazzolotto X, Nachon F
    Ref: Journal of Chromatography B Analyt Technol Biomed Life Sciences, 1102-1103:109, 2018 : PubMed

            

    Title: Bacterial Expression of Human Butyrylcholinesterase as a Tool for Nerve Agent Bioscavengers Development
    Brazzolotto X, Igert A, Guillon V, Santoni G, Nachon F
    Ref: Molecules, 22:, 2017 : PubMed

            

    Title: N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents
    Kosak U, Knez D, Coquelle N, Brus B, Pislar A, Nachon F, Brazzolotto X, Kos J, Colletier JP, Gobec S
    Ref: Bioorganic & Medicinal Chemistry, 25:633, 2017 : PubMed

            

    Title: Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study
    Rosenberry TL, Brazzolotto X, Macdonald IR, Wandhammer M, Trovaslet-Leroy M, Darvesh S, Nachon F
    Ref: Molecules, 22:, 2017 : PubMed

            

    Title: Discovery and Structure-Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening
    Dighe SN, Deora GS, De la Mora E, Nachon F, Chan S, Parat MO, Brazzolotto X, Ross BP
    Ref: Journal of Medicinal Chemistry, 59:7683, 2016 : PubMed

            

    Title: Development of an in-vivo active reversible butyrylcholinesterase inhibitor
    Kosak U, Brus B, Knez D, Sink R, Zakelj S, Trontelj J, Pislar A, Slenc J, Gobec M and Gobec S <15 more author(s)>
    Ref: Sci Rep, 6:39495, 2016 : PubMed

            

    Title: Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents
    Knez D, Brus B, Coquelle N, Sosic I, Sink R, Brazzolotto X, Mravljak J, Colletier JP, Gobec S
    Ref: Bioorganic & Medicinal Chemistry, 23:4442, 2015 : PubMed

            

    Title: Progress in the development of enzyme-based nerve agent bioscavengers
    Nachon F, Brazzolotto X, Trovaslet M, Masson P
    Ref: Chemico-Biological Interactions, 206:536, 2013 : PubMed

            

    Title: Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure
    Brazzolotto X, Wandhammer M, Ronco C, Trovaslet M, Jean L, Lockridge O, Renard PY, Nachon F
    Ref: Febs J, 279:2905, 2012 : PubMed

            

    Title: Organophosphate hydrolases as catalytic bioscavengers of organophosphorus nerve agents
    Trovaslet-Leroy M, Musilova L, Renault F, Brazzolotto X, Misik J, Novotny L, Froment MT, Gillon E, Loiodice M and Nachon F <4 more author(s)>
    Ref: Toxicol Lett, 206:14, 2011 : PubMed

            


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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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