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Year Report for: 2021

Aarsland_2021_Nat.Rev.Dis.Primers_7_47Parkinson disease-associated cognitive impairment
Abbad_2021_PLoS.One_16_e0258750Effect of identified non-synonymous mutations in DPP4 receptor binding residues among highly exposed human population in Morocco to MERS-CoV through computational approach
Abd_2021_Molecules_26_Essential Oils as a Potential Neuroprotective Remedy for Age-Related Neurodegenerative Diseases: A Review
Abdel-Aal_2021_Eur.J.Pharmacol_915_174695Naproxen as a potential candidate for promoting rivastigmine anti-Alzheimer activity against aluminum chloride-prompted Alzheimer's-like disease in rats; neurogenesis and apoptosis modulation as a possible underlying mechanism
Abdel-Salam_2021_Iran.J.Basic.Med.Sci_24_1437Inhibition of aluminum chloride-induced amyloid Abeta peptide accumulation and brain neurodegeneration by Bougainvillea spectabilis flower decoction
Abdelsalam_2021_J.Genet.Eng.Biotechnol_19_108Metabolic profiling, in vitro propagation, and genetic assessment of the endangered rare plant Anarrhinum pubescens
Abdelsayed_2021_J.Food.Biochem__e13992Niazimicin: A thiocarbamate glycoside from Moringa oleifera Lam. seeds with a novel neuroprotective activity
Abdollahdokht_2021_Environ.Sci.Pollut.Res.Int__Pesticide exposure and related health problems among farmworkers' children: a case-control study in southeast Iran
Abdou_2021_Environ.Sci.Pollut.Res.Int__Neurotoxicity and neuroinflammatory effects of bisphenol A in male rats: the neuroprotective role of grape seed proanthocyanidins
Abdpour_2021_Bioorg.Chem_110_104750Chromone derivatives bearing pyridinium moiety as multi-target-directed ligands against Alzheimer's disease
Abdulkadir_2021_J.Alzheimers.Dis__Taurine and Camel Milk Modulate Neurobehavioral and Biochemical Changes in Aluminum Chloride-Induced Alzheimer's Disease in Rats
Abdulrahim_2021_J.Cannabis.Res_3_38Cannabis sativa and/or melatonin do not alter brain lipid but alter oxidative mechanisms in female rats
Aboelhadid_2021_PLoS.One_16_e0260172Acaricidal activity of Foeniculum vulgare against Rhipicephalus annulatus is mainly dependent on its constituent from trans-anethone
Abokitse_2021_Appl.Environ.Microbiol__A Novel Actinobacterial Cutinase Containing a Non-Catalytic Polymer-Binding Domain
Abol-Fotouh_2021_Int.J.Biol.Macromol_181_125Optimization, purification, and biochemical characterization of thermoalkaliphilic lipase from a novel Geobacillus stearothermophilus FMR12 for detergent formulations
Abolins_2021_Materials.(Basel)_14_Impact of Different Epoxidation Approaches of Tall Oil Fatty Acids on Rigid Polyurethane Foam Thermal Insulation
Aboubakr_2021_Pharmaceuticals.(Basel)_14_Antioxidant and Anti-Inflammatory Potential of Thymoquinone and Lycopene Mitigate the Chlorpyrifos-Induced Toxic Neuropathy
Abrami_2021_Nat.Chem.Biol_17_438Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains
Abu-Taweel_2021_J.Trace.Elem.Med.Biol_68_126842Pomegranate juice moderates anxiety- and depression-like behaviors in AlCl(3)-treated male mice
Ackerman_2021_Nature__Astrocytes close a motor circuit critical period
Adaixo_2021_Biorxiv__Cryo-EM structure of native human thyroglobulin
Adebayo_2021_Drug.Metab.Pers.Ther__Cnidoscolus aconitifolius-supplemented diet enhanced neurocognition, endogenous antioxidants and cholinergic system and maintains hippocampal neuronal integrity in male Wistar rats
Adebayo_2021_Drug.Metab.Pers.Ther__2Long-term consumption of Moringa oleifera-supplemented diet enhanced neurocognition, suppressed oxidative stress, acetylcholinesterase activity and neuronal degeneration in rat's hippocampus
Adedara_2021_Environ.Sci.Pollut.Res.Int__Chronic ciprofloxacin and atrazine co-exposure aggravates locomotor and exploratory deficits in non-target detritivore speckled cockroach (Nauphoeta cinerea)
Adeel_2021_Int.J.Pharm__121374A Carrier Free Delivery System of a Monoacylglycerol Lipase Hydrophobic Inhibitor
Adeel_2021_J.Hazard.Mater_415_125574Bio-interaction of nano and bulk lanthanum and ytterbium oxides in soil system: Biochemical, genetic, and histopathological effects on Eisenia fetida
Adefegha_2021_Andrologia__e14074Berberine modulates crucial erectogenic biomolecules and alters histological architecture in penile tissues of diabetic rats
Adefegha_2021_J.Basic.Clin.Physiol.Pharmacol__Effects of berberine on cholinesterases and monoamine oxidase activities, and antioxidant status in the brain of streptozotocin (STZ)-induced diabetic rats
Adefegha_2021_J.Complement.Integr.Med__Comparative effects of berberine and piperine on the neuroprotective potential of neostigmine
Adefegha_2021_Metab.Brain.Dis__Moringa oleifera modulates cholinergic and purinergic enzymes activity in BV-2 microglial cells
Adefegha_2021_Toxicol.Res_37_249beta-caryophyllene improves sexual performance via modulation of crucial enzymes relevant to erectile dysfunction in rats
Adeowo_2021_Chem.Biodivers__Tailored Modeling of Rivastigmine Derivatives as Dual Acetylcholinesterase and Butyrylcholinesterase Inhibitors for Alzheimer's Disease Treatment
Adetunji_2021_Braz.J.Microbiol__Production strategies and biotechnological relevance of microbial lipases: a review
Adewole_2021_In.Silico.Pharmacol_9_14BACE1 and cholinesterase inhibitory activities of compounds from Cajanus cajan and Citrus reticulata: an in silico study
Adhikari_2021_Toxicol.Rep_8_1883Gradual reduction of susceptibility and enhanced detoxifying enzyme activities of laboratory-reared Aedes aegypti under exposure of temephos for 28 generations
Adib_2021_Saudi.J.Biol.Sci_28_3893Cholinesterase inhibitory activity of tinosporide and 8-hydroxytinosporide isolated from Tinospora cordifolia: In vitro and in silico studies targeting management of Alzheimer's disease
Adina_2021_J.Genet.Eng.Biotechnol_19_55Expression of novel acidic lipase from Micrococcus luteus in Pichia pastoris and its application in transesterification
Adole_2021_Anal.Biochem__114158Clinical utility of validated gas chromatography-ion trap mass spectrometry in patients with anticholinesterase pesticides poisoning
Afsa_2021_Environ.Sci.Pollut.Res.Int__A multi-biomarker approach for the early assessment of the toxicity of hospital wastewater using the freshwater organism Daphnia magna
Afzal_2021_Molecules_26_Analgesic and Anticancer Activity of Benzoxazole Clubbed 2-Pyrrolidinones as Novel Inhibitors of Monoacylglycerol Lipase
Afzali_2021_Drug.Res.(Stuttg)_71_10Investigating the Effect of Fresh Frozen Plasma and Albumin on DNA Damage and Oxidative Stress Biomarkers in Poisoning Cases by Organophosphates
Agami_2021_Anal.Bioanal.Chem__LC-MS bioanalysis of targeted nasal galantamine bound chitosan nanoparticles in rats' brain homogenate and plasma
Agostini_2021_Neurosci_455_251Gallic Acid Reverses Neurochemical Changes Induced by Prolonged Ethanol Exposure in the Zebrafish Brain
Agrawal_2021_Bioresour.Technol_339_125603Economizing the lignocellulosic hydrolysis process using heterologously expressed auxiliary enzymes feruloyl esterase D (CE1) and beta-xylosidase (GH43) derived from thermophilic fungi Scytalidium thermophilum
Aguera-Ortiz_2021_Front.Psychiatry_12_638651Depression in Alzheimer's Disease: A Delphi Consensus on Etiology, Risk Factors, and Clinical Management
Aguirre-Rojas_2021_Sci.Rep_11_11448Comparative analyses of transcriptional responses of Dectes texanus LeConte (Coleoptera: Cerambycidae) larvae fed on three different host plants and artificial diet
Agwa_2021_Cells_10_ABHD4-Regulating RNA Panel: Novel Biomarkers in Acute Coronary Syndrome Diagnosis
Ahammed_2021_Adv.Pharmacol.Pharm.Sci_2021_5569054Acetylcholinesterase Inhibitory and Antioxidant Activity of the Compounds Isolated from Vanda roxburghii
Ahmad_2021_Biorxiv__Substrate access mechanism in a novel membrane-bound 1 phospholipase A of Pseudomonas aeruginosa concordant with specificity and regioselectivity
Ahmad_2021_Curr.Neuropharmacol__Study of Nutraceuticals and Phytochemicals for the Management of Alzheimer's Disease: A Review
Ahmad_2021_Curr.Opin.Infect.Dis_34_187Bacterial RTX toxins and host immunity
Ahmad_2021_Molecules_26_Biocomputational Screening of Natural Compounds against Acetylcholinesterase
Ahmad_2021_Saudi.J.Biol.Sci_28_6352Evaluation of analgesic, antiamnesic and antidiarrheal potentials of Medicago denticulata extract using animal model
Ahmaditabatabaei_2021_J.Fungi.(Basel)_7_Fungal Enzymes as Catalytic Tools for Polyethylene Terephthalate (PET) Degradation
Ahmed_2021_Biomed.Pharmacother_139_111609Potential therapeutic natural products against Alzheimer's disease with Reference of Acetylcholinesterase
Ahmed_2021_Environ.Sci.Pollut.Res.Int_28_2146Premna odorata extract as a protective agent on neurotoxic effect of aluminum: neurochemical, molecular, and histopathological alterations
Ahmed_2021_J.Biomol.Struct.Dyn__1Computational and SAXS-based structure insights of pectin acetyl esterase (CtPae12B) of family 12 carbohydrate esterase from Clostridium thermocellum ATCC 27405
Ahmed_2021_J.Venom.Anim.Toxins.Incl.Trop.Dis_27_e20200047Kinetic and toxicological effects of synthesized palladium(II) complex on snake venom (Bungarus sindanus) acetylcholinesterase
Ahsan_2021_Inflammopharmacology__Pharmacological support to anti-arthritic prospective of physostigmine: a new approach
Ahsan_2021_J.Basic.Microbiol__Enzyme-assisted bioremediation approach for synthetic dyes and polycyclic aromatic hydrocarbons degradation
Ahuja-Casarin_2021_J.Enzyme.Inhib.Med.Chem_36_138Tuning the activity of iminosugars: novel N-alkylated deoxynojirimycin derivatives as strong BuChE inhibitors
Aissa_2021_Bioorg.Med.Chem.Lett__128000Fiaud's Acid, a novel organocatalyst for diastereoselective bis alpha-aminophosphonates synthesis with in-vitro biological evaluation of antifungal, antioxidant and enzymes inhibition potential
Ajayi_2021_Metabol.Open_9_100077High-fat diet-induced memory impairment and anxiety-like behavior in rats attenuated by peel extract of Ananas comosus fruit via atheroprotective, antioxidant and anti-inflammatory actions
Ajima_2021_Environ.Sci.Pollut.Res.Int__Sublethal diclofenac induced oxidative stress, neurotoxicity, molecular responses and alters energy metabolism proteins in Nile tilapia, Oreochromis niloticus
Ak_2021_Food.Chem.Toxicol_153_112268Tanacetum vulgare L. (Tansy) as an effective bioresource with promising pharmacological effects from natural arsenal
Akaberi_2021_Phytochemistry_191_112923Phytochemistry and pharmacology of alkaloids from Glaucium spp
Akbar_2021_J.Food.Biochem__e13936Neuroprotective potential of berberine in modulating Alzheimer's disease via multiple signaling pathways
Akdag_2021_Biotechnol.Appl.Biochem_68_1113Conducting polymer-based electrochemical biosensor for the detection of acetylthiocholine and pesticide via acetylcholinesterase
Akhtar_2021_Psychopharmacology.(Berl)__7,8-Dihydroxyflavone improves cognitive functions in ICV-STZ rat model of sporadic Alzheimer's disease by reversing oxidative stress, mitochondrial dysfunction, and insulin resistance
Akincioglu_2021_Comput.Biol.Chem_94_107565Cholinesterases, carbonic anhydrase inhibitory properties and in silico studies of novel substituted benzylamines derived from dihydrochalcones
Akintunde_2021_Biochem.Biophys.Rep_26_100999Biogenic zinc-oxide nanoparticles of Moringa oleifera leaves abrogates rotenone induced neuroendocrine toxicity by regulation of oxidative stress and acetylcholinesterase activity
Akkol_2021_Curr.Neuropharmacol__Effects of Natural Products on Neuromuscular Junction
Akocak_2021_Chem.Biodivers__Synthesis, characterization, and inhibition study of novel substituted phenylureido sulfaguanidine derivatives as alpha-glycosidase and cholinesterase inhibitors
Akomolafe_2021_J.Food.Biochem__e13629Diets supplemented with raw and roasted pumpkin (Cucurbita pepo L) seeds improved some biochemical parameters associated with erectile function in rats
Akpa_2021_Toxicol.Res_37_163Protective effect of fisetin against subchronic chlorpyrifos-induced toxicity on oxidative stress biomarkers and neurobehavioral parameters in adult male albino mice
Al Hamoui Dit Banni_2021_Analyst_146_1386Screening for pancreatic lipase natural modulators by capillary electrophoresis hyphenated to spectrophotometric and conductometric dual detection
Al Mughairbi_2021_Saudi.Pharm.J_29_1043Neuroprotective effects of Bhilawanol and Anacardic acid during glutamate-induced neurotoxicity
Al-Aqaba_2021_Br.J.Ophthalmol_105_285In vivo confocal microscopy features and clinicohistological correlation of limbal nerve corpuscles
Al-Brakati_2021_Neurotox.Res_39_198Possible Role of Kaempferol in Reversing Oxidative Damage, Inflammation, and Apoptosis-Mediated Cortical Injury Following Cadmium Exposure
Al-Emam_2021_Toxicol.Rep_8_1226Butyryl-cholinesterase deficiency: A case report of delayed recovery after general anaesthesia
Al-Hamed_2021_Alzheimers.Dement.(N.Y)_7_e12184Acetylcholinesterase inhibitors and risk of bleeding and acute ischemic events in non-hypertensive Alzheimer's patients
Al-Hazmi_2021_Metab.Brain.Dis__Biochemical, histological, and neuro-physiological effects of long-term aluminum chloride exposure in rats
Al-Kuraishy_2021_Front.Cardiovasc.Med_8_644095COVID-19 in Relation to Hyperglycemia and Diabetes Mellitus
Al-Samawi_2021_Indian.Heart.J__Association of the lipoprotein lipase and Apolipoprotein C-II gene polymorphisms with risk of dyslipidemia in smokers and non-smokers male
Al-Serri_2021_Saudi.J.Biol.Sci_28_4717Association between the lipoprotein lipase rs1534649 gene polymorphism in intron one with Body Mass Index and High Density Lipoprotein-Cholesterol
Al-Zaban_2021_Molecules_26_HPLC-Analysis, Biological Activities and Characterization of Action Mode of Saudi Marrubium vulgare against Foodborne Diseases Bacteria
Alabbas_2021_BMC.Pediatr_21_72Wolman's disease presenting with secondary hemophagocytic lymphohistiocytosis: a case report from Saudi Arabia and literature review
Alarcon-Esposito_2021_Curr.Neuropharmacol_19_832From Hybrids to New Scaffolds: The Latest Medicinal Chemistry Goals in Multi-target Directed Ligands for Alzheimer's Disease
Albendin_2021_Int.J.Environ.Res.Public.Health_18_Pharmaceutical Products and Pesticides Toxicity Associated with Microplastics (Polyvinyl Chloride) in Artemia salina
Albertini_2021_Med.Res.Rev_41_2606From combinations to multitarget-directed ligands: A continuum in Alzheimer's disease polypharmacology
Alberto-Silva_2021_Toxins.(Basel)_13_Comprehensive Analysis and Biological Characterization of Venom Components from Solitary Scoliid Wasp Campsomeriella annulata annulata
Albrakati_2021_Int.J.Nanomedicine_16_8447Neuroprotective Efficiency of Prodigiosins Conjugated with Selenium Nanoparticles in Rats Exposed to Chronic Unpredictable Mild Stress is Mediated Through Antioxidative, Anti-Inflammatory, Anti-Apoptotic, and Neuromodulatory Activities
Alejandro_2021_Environ.Monit.Assess_194_23Temporal and spatial analysis of benomyl/carbendazim in water and its possible impact on Nile tilapia (Oreochromis niloticus) from Tenango dam, Puebla, Mexico
Alex_2021_Anal.Chim.Acta_1142_73An ultra-sensitive and selective AChE based colorimetric detection of malathion using silver nanoparticle-graphene oxide (Ag-GO) nanocomposite
Alexander_2021_Proteins__Target highlights in CASP14: Analysis of models by structure providers
Alexandris_2021_Toxicol.Rep_8_73Nicotinic cholinergic system and COVID-19: In silico evaluation of nicotinic acetylcholine receptor agonists as potential therapeutic interventions
Alhatali_2021_Clin.Toxicol.(Phila)__1A cluster of tetrodotoxin poisoning in Oman
Alhawarri_2021_Molecules_26_Antioxidant, Anti-Inflammatory, and Inhibition of Acetylcholinesterase Potentials of Cassia timoriensis DC. Flowers
Ali_2021_Exp.Aging.Res__1Behavioral, Biochemical and Histopathological effects of Standardised Pomegranate extract with Vinpocetine, Propolis or Cocoa in a rat model of Parkinson's disease
Ali_2021_Int.Immunopharmacol_96_107729Natural antioxidants enhance the power of physical and mental activities versus risk factors inducing progression of Alzheimer's disease in rats
Ali_2021_Int.J.Biol.Macromol__Sequence and structure-based method to predict diacylglycerol lipases in protein sequence
Ali_2021_Neurochem.Res__Screening of Synthetic Isoxazolone Derivative Role in Alzheimer's Disease: Computational and Pharmacological Approach
Ali_2021_Sci.Total.Environ_780_146590Plastic wastes biodegradation: Mechanisms, challenges and future prospects
Ali_2021_Spectrochim.Acta.A.Mol.Biomol.Spectrosc_263_120180Structure and biomolecular recognition of nitro-BODIPY-andrographolide assembles for cancer treatment
Alikhani_2021_Iran.J.Pharm.Res_20_560Response Surface Study on Molecular Docking Simulations of Citalopram and Donepezil as Potent CNS Drugs
Aliomrani_2021_Neurotoxicol.Teratol__106957-AChR is partly responsible in mice depressive-like behavior after Phosalone exposure
Almadiy_2021_Environ.Sci.Pollut.Res.Int__Bioactivity and safety evaluations of Cupressus sempervirens essential oil, its nanoemulsion and main terpenes against Culex quinquefasciatus Say
Almeida_2021_Environ.Toxicol.Pharmacol__103634Can the insecticide imidacloprid affect the health of the Neotropical freshwater fish Astyanax altiparanae (Teleostei: Characidae)?
Almeida_2021_J.Inorg.Biochem_224_111560Probing the acetylcholinesterase inhibitory activity of a novel Ru(II) polypyridyl complex and the supramolecular interaction by (STD)-NMR
Alonso_2021_Int.J.Biol.Macromol__Discovery of tight-binding competitive inhibitors of dipeptidyl peptidase IV
Alqahtani_2021_Steroids_172_108857Bioactive stigmastadienone from Isodon rugosus as potential anticholinesterase, alpha-glucosidase and COX/LOX inhibitor: In-vitro and molecular docking studies
Alshehri_2021_Biomolecules_11_Rosinidin Attenuates Lipopolysaccharide-Induced Memory Impairment in Rats: Possible Mechanisms of Action Include Antioxidant and Anti-Inflammatory Effects
Altaf_2021_Hum.Exp.Toxicol__960327121993207Cell membrane enveloped polymeric nanosponge for detoxification of chlorpyrifos poison: In vitro and in vivo studies
Alugubelly_2021_Neurotoxicol__Persistent proteomic changes in glutamatergic and GABAergic signaling in the amygdala of adolescent rats exposed to chlorpyrifos as juveniles
Alves_2021_Bioprocess.Biosyst.Eng_44_57Design for preparation of more active cross-linked enzyme aggregates of Burkholderia cepacia lipase using palm fiber residue
Alves_2021_Braz.J.Biol_81_632The acetylcholinesterase as indicative of intoxication for pesticide in farmers of conventional and organic cultivation
Alvi_2021_Oxid.Med.Cell.Longev_2021_9966663Carveol Attenuates Seizure Severity and Neuroinflammation in Pentylenetetrazole-Kindled Epileptic Rats by Regulating the Nrf2 Signaling Pathway
Aly_2021_IBRO.Neurosci.Rep_10_109Targeting the endocannabinoid system for management of HIV-associated neuropathic pain: A systematic review
Alzweiri_2021_Bioorg.Med.Chem.Lett__128205The structural simplification of lysergic acid as a natural lead for synthesizing novel anti-Alzheimer agents
Amala_2021_Molecules_26_Bioefficacy of Epaltes divaricata (L.) n-Hexane Extracts and Their Major Metabolites against the Lepidopteran Pests Spodoptera litura (fab.) and Dengue Mosquito Aedes aegypti (Linn.)
Aman_2021_Crit.Care.Clin_37_673Management of Organophosphorus Poisoning: Standard Treatment and Beyond
Amat-Ur-Rasool_2021_Brain.Sci_11_Anti-Cholinesterase Combination Drug Therapy as a Potential Treatment for Alzheimer's Disease
Amat-Ur-Rasool_2021_Curr.Issues.Mol.Biol_44_152In Silico Design of Dual-Binding Site Anti-Cholinesterase Phytochemical Heterodimers as Treatment Options for Alzheimer's Disease
Amezian_2021_Insect.Biochem.Mol.Biol_138_103646Comparative analysis of the detoxification gene inventory of four major Spodoptera pest species in response to xenobiotics
Amin_2021_Bioorg.Chem_110_104792Design and synthesis of novel coumarin derivatives as potential acetylcholinesterase inhibitors for Alzheimer's disease
Amin_2021_Biotechnol.Appl.Biochem__Penicillium fellutanum lipase as a green and ecofriendly biocatalyst for depolymerization of poly (sigma-caprolactone): Biochemical, kinetic, and thermodynamic investigations
Amin_2021_Environ.Technol__1Cholinesterase activity as a potential biomarker for neurotoxicity induced by pesticides in vivo exposed Oreochromis niloticus (Nile tilapia)
Amin_2021_Front.Physiol_12_628107Melatonin-Pretreated Mesenchymal Stem Cells Improved Cognition in a Diabetic Murine Model
Amirahmadi_2021_Metab.Brain.Dis__Folic acid attenuated learning and memory impairment via inhibition of oxidative damage and acetylcholinesterase activity in hypothyroid rats
Amitai_2021_Commun.Biol_4_573Non-quaternary oximes detoxify nerve agents and reactivate nerve agent-inhibited human butyrylcholinesterase
An_2021_J.Clin.Pharmacol_61_531Target-Mediated Drug Disposition-A Class Effect of Soluble Epoxide Hydrolase Inhibitors
Anantayanon_2021_Gene__145745Significance of two intracellular triacylglycerol lipases of Aspergillus oryzae in lipid mobilization: A perspective in industrial implication for microbial lipid production
Anastassiadou_2021_EFSA.J_19_e06392Cumulative dietary risk assessment of chronic acetylcholinesterase inhibition by residues of pesticides
Andersson_2021_Methods.Mol.Biol_2309_245Structural Analysis of Strigolactone-Related Gene Products
Andrejcakova_2021_Saudi.J.Biol.Sci_28_3789Dietary flaxseed's protective effects on body tissues of mice after oral exposure to xylene
Andrys_2021_Mol.Pharm__Effect of Oxime Encapsulation on Acetylcholinesterase Reactivation: Pharmacokinetic Study of the Asoxime-Cucurbit[7]uril Complex in Mice Using Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry
Angeloni_2021_Plants.(Basel)_10_Phytochemical Profile and Biological Activities of Crude and Purified Leonurus cardiaca Extracts
Anglister_2021_J.Neurochem__Preface: Cholinergic mechanisms: This is the Preface for the special issue Cholinergic Mechanisms
Angrand_2021_Toxicology__152787Persistent brainwave disruption and cognitive impairment induced by acute sarin surrogate sub-lethal dose exposure
Anita_2021_Psychoneuroendocrinology_126_105149Serum soluble epoxide hydrolase related oxylipins and major depression in patients with type 2 diabetes
Anjireddy_2021_Mini.Rev.Med.Chem__A new mode of Thinfilm and Nanofiber for burst release of the drug for Alzheimer disease; A complete scenario from dispersible polymer to formulation methodology
Annac_2021_J.Food.Biochem__e13881The protective effects of pomegranate juice on lead acetate-induced neurotoxicity in the male rat: A histomorphometric and biochemical study
Ansari_2021_Arch.Pharm.(Weinheim)__e2100376Biology-oriented drug synthesis and evaluation of secnidazole esters as novel enzyme inhibitors
Antoniolli_2021_Curr.Med.Chem_28_4259Chalcones Acting as Inhibitors of Cholinesterases, beta-Secretase and beta- Amyloid Aggregation and other Targets for Alzheimer's Disease: A Critical Review
Anukanon_2021_ACS.Omega_6_19924In Silico-Guided Rational Drug Design and Semi-synthesis of C(2)-Functionalized Huperzine A Derivatives as Acetylcholinesterase Inhibitors
Anupama_2021_J.Biomol.Struct.Dyn__1Jatamansinol from Nardostachys jatamansi: a multi-targeted neuroprotective agent for Alzheimer's disease
Anwar_2021_Antioxidants.(Basel)_10_A Leaf Extract of Harrisonia abyssinica Ameliorates Neurobehavioral, Histological and Biochemical Changes in the Hippocampus of Rats with Aluminum Chloride-Induced Alzheimer's Disease
Arafa_2021_Vet.Parasitol_290_109346Control of Rhipicephalus annulatus resistant to deltamethrin by spraying infested cattle with synergistic eucalyptus essential oil-thymol-deltamethrin combination
Aramjoo_2021_Environ.Sci.Pollut.Res.Int__Modulatory effect of opioid administration on the activity of cholinesterase enzyme: a systematic review of mice/rat models
Araujo_2021_ACS.Med.Chem.Lett_12_548Glucosamine and Its Analogues as Modulators of Amyloid-beta Toxicity
Araujo_2021_Environ.Sci.Pollut.Res.Int__Effects of exposure to the UV-filter 4-MBC during Solea senegalensis metamorphosis
Arellano-Saab_2021_Proc.Natl.Acad.Sci.U.S.A_118_Three mutations repurpose a plant karrikin receptor to a strigolactone receptor
Aresti-Sanz_2021_Pharmaceuticals.(Basel)_14_Stability of Methylphenidate under Various pH Conditions in the Presence or Absence of Gut Microbiota
Arora_2021_Ecotoxicol.Environ.Saf_226_112790Mixture toxicity assessment of selected insecticides to silver perch fingerling, Bidyanus bidyanus
Arranz San Martin_2022_Biomolecules_12_170Enzyme-Mediated Quenching of the Pseudomonas Quinolone Signal (PQS): A Comparison between Naturally Occurring and Engineered PQS-Cleaving Dioxygenases
Arshad_2021_Biomolecules_11_RP-UHPLC-MS Chemical Profiling, Biological and In Silico Docking Studies to Unravel the Therapeutic Potential of Heliotropium crispum Desf. as a Novel Source of Neuroprotective Bioactive Compounds
Arya_2021_Biomolecules_11_Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer's Disease Therapy
Arya_2021_Front.Plant.Sci_12_663165The Plant Cuticle: An Ancient Guardian Barrier Set Against Long-Standing Rivals
Arya_2021_Plant.Physiol.Biochem_161_234Brassica juncea leaf cuticle proteome analysis shows myrosinase protein, antifreeze activity, and post-translationally modified secretory proteins
Asada_2021_Biochem.Biophys.Res.Commun_549_105Secretory production of a camelid single-domain antibody (VHH, nanobody) by the Serratia marcescens Lip system in Escherichia coli
Ashok_2021_Bioorg.Med.Chem.Lett__128212Design, synthesis and biological evaluation of novel deoxyvasicinone-indole as multi-target agents for Alzheimer's disease
Askin_2021_Bioorg.Chem_113_105009Design, synthesis, characterization, in vitro and in silico evaluation of novel imidazo[2,1-b][1,3,4]thiadiazoles as highly potent acetylcholinesterase and non-classical carbonic anhydrase inhibitors
Aslam_2021_Biomed.Res.Int_2021_6631042Anti-5'-Nucleotidases (5'-ND) and Acetylcholinesterase (AChE) Activities of Medicinal Plants to Combat Echis carinatus Venom-Induced Toxicities
Atalar_2021_J.Food.Biochem__e13975The effects of Daucus carota extract against PC3, PNT1a prostate cells, acetylcholinesterase, glutathione S-transferase, and alpha-glycosidase; an in vitro-in silico study
Atamanalp_2021_Toxicol.Mech.Methods__1Treatment of Oxidative Stress, Apoptosis, and DNA Injury with N-acetylcysteine at simulative pesticide toxicity in fish
Atanasova_2021_Int.J.Mol.Sci_22_Plastic Degradation by Extremophilic Bacteria
Ateba_2021_Front.Pharmacol_12_641225The Genus Eriosema (Fabaceae): From the Ethnopharmacology to an Evidence-Based Phytotherapeutic Perspective?
Ates_2021_Z.Naturforsch.C.J.Biosci__New indane derivatives containing 2-hydrazinothiazole as potential acetylcholinesterase and monoamine oxidase-B inhibitors
Athar_2021_Mol.Biol.Rep__Recent advances on drug development and emerging therapeutic agents for Alzheimer's disease
Atrahimovich_2021_Metabolites_11_Galantamine Quantity and Alkaloid Profile in the Bulbs of Narcissus tazetta and daffodil cultivars (Amaryllidaceae) Grown in Israel
Attademo_2021_Environ.Sci.Pollut.Res.Int__Effects of the emulsifiable herbicide Dicamba on amphibian tadpoles: an underestimated toxicity risk?
Attarroshan_2021_Chem.Biodivers__Imino-2H-chromene based derivatives as potential anti-Alzheimer's agents: Design, synthesis, biological evaluation and in silico study
Avolio_2021_Vet.Anim.Sci_13_100178Retrospective data analysis of animal poisoning events in Liguria
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Bruszt_2021_Psychopharmacology.(Berl)__Potentiation of cognitive enhancer effects of Alzheimer's disease medication memantine by alpha7 nicotinic acetylcholine receptor agonist PHA-543613 in the Morris water maze task
Bryant_2021_Science_372_Stepwise pathogenic evolution of Mycobacterium abscessus
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Bzdrenga_2021_Molecules_26_657A Thermophilic Bacterial Esterase for Scavenging Nerve Agents: A Kinetic, Biophysical and Structural Study
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Cai_2021_Anal.Chem__Capsulation of AuNCs with AIE Effect into Metal-Organic Framework for the Marriage of a Fluorescence and Colorimetric Biosensor to Detect Organophosphorus Pesticides
Cai_2021_Molecules_26_Bioactive Polyketide and Diketopiperazine Derivatives from the Mangrove-Sediment-Derived Fungus Aspergillus sp. SCSIO41407
Cairone_2021_Molecules_26_Health Potential of Clery Strawberries: Enzymatic Inhibition and Anti-Candida Activity Evaluation
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Calabretta_2021_Anal.Chem__Ultrasensitive On-Field Luminescence Detection Using a Low-Cost Silicon Photomultiplier Device
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Calderini_2021_Chembiochem__Simple plug-in synthetic step for the synthesis of (-)-camphor from renewable starting materials
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Cannon_2021_Photochem.Photobiol__Caged Oxime Reactivators Designed for the Light Control of Acetylcholinesterase Reactivation
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Chen_2021_Phytochemistry_186_112730Pyrrolyl 4-quinolone alkaloids from the mangrove endophytic fungus Penicillium steckii SCSIO 41025: Chiral resolution, configurational assignment, and enzyme inhibitory activities
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Goncalves_2021_Molecules_26_Impact of Metallic Nanoparticles on In Vitro Culture, Phenolic Profile and Biological Activity of Two Mediterranean Lamiaceae Species: Lavandula viridis L'Her and Thymus lotocephalus G. Lopez and R. Morales
Gong_2021_Bioengineered_12_5241Notum palmitoleoyl-protein carboxylesterase regulates Fas cell surface death receptor-mediated apoptosis via the Wnt signaling pathway in colon adenocarcinoma
Gong_2021_Insect.Sci__Molecular and functional characterization of three novel carboxylesterases in the detoxification of permethrin in the mosquito, Culex quinquefasciatus
Gong_2021_Mol.Divers__A novel artificial intelligence protocol to investigate potential leads for diabetes mellitus
Gonzalez-Barrio_2021_Parasit.Vectors_14_488Changes in serum biomarkers of inflammation in bovine besnoitiosis
Gonzalez-Morales_2021_J.Med.Entomol__Resistance to Fipronil in the Common Bed Bug (Hemiptera: Cimicidae)
Gonzalez_2021_Curr.Res.Toxicol_2_341Sex-specific acute and chronic neurotoxicity of acute diisopropylfluorophosphate (DFP)-intoxication in juvenile Sprague-Dawley rats
Gopi_2021_Comp.Biochem.Physiol.C.Toxicol.Pharmacol__109161Interactive effects of freshwater acidification and selenium pollution on biochemical changes and neurotoxicity in Oreochromis mossambicus
Gordon_2021_Exp.Neurol__113717Peripheral nerves preferentially regenerate in intramuscular endoneurial tubes to reinnervate denervated skeletal muscles
Gorecki_2021_ACS.Chem.Neurosci__Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer's Disease
Gorecki_2021_Arch.Toxicol__Development of versatile and potent monoquaternary reactivators of acetylcholinesterase
Gorecki_2021_Eur.J.Med.Chem_219_113434Structure-activity relationships of dually-acting acetylcholinesterase inhibitors derived from tacrine on N-methyl-d-Aspartate receptors
Gorelik_2021_Sci.Adv_7_eabf4155Structure of the murine lysosomal multienzyme complex core
Gori_2021_Top.Curr.Chem.(Cham)_379_33Organic-Molecule-Based Fluorescent Chemosensor for Nerve Agents and Organophosphorus Pesticides
Goryainova_2021_Crystallogr.Rep_66_811Three-Dimensional Structure of Single-Point Mutant of Esterase PMGL2
Gorzi_2021_Mol.Neurobiol__Training Intensity, Not Duration, May Be Key to Upregulating Presynaptic Proteins of Calcium Dynamics and Calcium-Dependent Exocytosis in Fast- and Slow-Twitch Skeletal Muscles, in Addition to Maintaining Performance After Detraining
Gowayed_2021_BMC.Pharmacol.Toxicol_22_24The effective interplay of (non-) selective NSAIDs with neostigmine in animal models of analgesia and inflammation
Gowler_2021_Arthritis.Rheumatol__Clinical and preclinical evidence for roles of soluble epoxide hydrolase in osteoarthritis knee pain
Gozutok_2021_Brain.Sci_11_Mutations and Protein Interaction Landscape Reveal Key Cellular Events Perturbed in Upper Motor Neurons with HSP and PLS
Graf_2021_J.Pharm.Sci__Identification and Characterization of Polysorbate-Degrading Enzymes in a Monoclonal Antibody Formulation
Graf_2021_Methods.Enzymol_648_337Structural analysis of PET-degrading enzymes PETase and MHETase from Ideonella sakaiensis
Graikou_2021_Planta.Med__Chemical Characterisation-Biological Evaluation of Greek Cultivar Cardoon Seeds (Cynara cardunculus). A By-product with Potential High Added Value
Grajales-Hernandez_2021_Appl.Microbiol.Biotechnol__Approaches for the enzymatic synthesis of alkyl hydroxycinnamates and applications thereof
Granada_2021_PLoS.Negl.Trop.Dis_15_e0010001Molecular surveillance of resistance to pyrethroids insecticides in Colombian Aedes aegypti populations
Grau-Bove_2021_PLoS.Genet_17_e1009253Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locus
Gravato_2021_Methods.Mol.Biol_2240_119Acetylcholinesterase (AChE) Activity in Embryos of Zebrafish
Gravdal_2021_J.Biol.Chem_296_100661The position of single-base deletions in the VNTR sequence of the carboxyl ester lipase (CEL) gene determines proteotoxicity
Grcic_2021_Environ.Pollut_288_117706Sensitivity of midgut physiological parameters of Lymantria dispar L. larvae to benzo[a]pyrene in populations with different multigeneration contact to environmental pollutants
Greene_2021_Biomacromolecules_22_19993D-Printed Enzyme-Embedded Plastics
Greene_2021_J.Emerg.Med_60_197Monocled Cobra (Naja kaouthia) Envenomations Requiring Mechanical Ventilation
Grevengoed_2021_J.Clin.Invest_131_An abundant biliary metabolite derived from dietary omega-3 polyunsaturated fatty acids regulates triglycerides
Griffin_2021_Cells_10_Integrated Action of Autophagy and Adipose Tissue Triglyceride Lipase Ameliorates Diet-Induced Hepatic Steatosis in Liver-Specific PLIN2 Knockout Mice
Grigorev_2021_Mol.Inform__Structural Fractal Analysis of the Active Site of Acetylcholinesterase in Complexes with Huperzine A, Galantamine, and Donepezil
Grinan-Ferre_2021_Int.J.Mol.Sci_22_Inhibition of Soluble Epoxide Hydrolase Ameliorates Phenotype and Cognitive Abilities in a Murine Model of Niemann Pick Type C Disease
Grininger_2021_Biomolecules_11_1299Structural Changes in the Cap of Rv0183/mtbMGL Modulate the Shape of the Binding Pocket
Grodner_2021_Int.J.Mol.Sci_23_In Vitro and In Silico Kinetic Studies of Patented 1,7-diEthyl and 1,7-diMethyl Aminoalkanol Derivatives as New Inhibitors of Acetylcholinesterase
Grott_2021_Sci.Total.Environ_771_144971Influence of temperature on biomarker responses and histology of the liver of American bullfrog tadpoles (Lithobates catesbeianus, Shaw, 1802) exposed to the herbicide Tebuthiuron
Gruber-Dorninger_2021_Toxins.(Basel)_13_Metabolism of Zearalenone in the Rumen of Dairy Cows with and without Application of a Zearalenone-Degrading Enzyme
Gu_2021_Ann.Palliat.Med_10_12566Sugammadex enhances recovery after abdominal surgery in cancer patients: a real-world, observational study
Gu_2021_Int.J.Biol.Macromol_171_382Characteristics of a recombinant Fusarium verticillioides cutinase and its effects on enzymatic hydrolysis of rice straw
Gu_2021_J.Gene.Med__e3403Silencing of circDPP4 suppresses cell progression of human prostate cancer and enhances docetaxel cytotoxicity through regulating miR-564/ZIC2 axis
Guan_2021_Bioorg.Med.Chem.Lett__128306Design, synthesis, and cholinesterase inhibition assay of liquiritigenin derivatives as anti-Alzheimer's activity
Guan_2021_Front.Bioeng.Biotechnol_9_806788Biochemical and Structural Characterization of a Novel Bacterial Tannase From Lachnospiraceae bacterium in Ruminant Gastrointestinal Tract
Guan_2021_Insect.Sci_28_627Whole-genome sequencing to detect mutations associated with resistance to insecticides and Bt proteins in Spodoptera frugiperda
Guan_2021_Int.J.Mol.Sci_22_Epoxyeicosatrienoic Acids and Fibrosis: Recent Insights for the Novel Therapeutic Strategies
Guan_2021_Talanta_225_121948Fluorometric probe for the lipase level: Design, mechanism and biological imaging application
Guenther_2021_Eur.J.Anaesthesiol_38_554Low cholinesterase activity is a risk factor for delirium after cardiac surgery: A prospective cohort study
Guerra_2021_Arch.Environ.Contam.Toxicol__Biochemical and Behavioral Responses in Zebrafish Exposed to Imidacloprid Oxidative Damage and Antioxidant Responses
Guillory_2021_Methods.Mol.Biol_2309_143Methods for Medium-Scale Study of Biological Effects of Strigolactone-Like Molecules on the Moss Physcomitrium (Physcomitrella) patens
Guillory_2021_Plant.Mol.Biol__Phytohormone biosynthesis and signaling pathways of mosses
Guimaraes_2021_Aquat.Toxicol_233_105795Can carbon nanofibers affect anurofauna? Study involving neotropical Physalaemus cuvieri (Fitzinger, 1826) tadpoles
Guimaraes_2021_J.Hazard.Mater_403_123864Nanopolystyrene particles at environmentally relevant concentrations causes behavioral and biochemical changes in juvenile grass carp (Ctenopharyngodon idella)
Guimaraes_2021_Sci.Total.Environ_779_146514Multiple toxicity endpoints induced by carbon nanofibers in Amazon turtle juveniles: Outspreading warns about toxicological risks to reptiles
Gul_2021_Acta.Neurol.Belg_121_529Congenital myasthenic syndrome in Turkey: clinical and genetic features in the long-term follow-up of patients
Gulcan_2021_Curr.Top.Med.Chem_21_2752Dual monoamine oxidase and cholinesterase Inhibitors with different heterocyclic scaffolds
Gulcan_2021_Curr.Top.Med.Chem__The hybrid compounds as multi-target ligands for the treatment of Alzheimer's Disease: Considerations on Donepezil
Guller_2021_Altern.Ther.Health.Med_27_33Radical Scavenging and Antiacetylcholinesterase Activities of Ethanolic Extracts of Carob, Clove, and Linden
Gumus_2021_Arch.Pharm.(Weinheim)__e2100242Discovery of sulfadrug-pyrrole conjugates as carbonic anhydrase and acetylcholinesterase inhibitors
Gunay_2021_Semin.Cell.Dev.Biol_112_92Importance of lipids for upper motor neuron health and disease
Gunderson_2021_Toxicol.Sci__Neuroligin-1 is a mediator of methylmercury neuromuscular toxicity
Gundlach_2021_Sci.Total.Environ_792_148368Effects of the antidepressant mirtazapine on the swimming behaviour and gene expression rate of Danio rerio embryos - Is the sedating effect seen in humans also evident for fish?
Gunsel_2021_J.Biomol.Struct.Dyn__1Novel tetrakis-phthalocyanines bearing pyrimidine derivative: crystal XRD analysis, enzyme inhibition, molecular docking, and anticancer effects
Guo_2021_Anal.Bioanal.Chem_413_5835Desorption electrospray ionization (DESI) source coupling ion mobility mass spectrometry for imaging fluoropezil (DC20) distribution in rat brain
Guo_2021_Anal.Chem__Multienzyme-Targeted Fluorescent Probe as a Biosensing Platform for Broad Detection of Pesticide Residues
Guo_2021_Bioengineered_12_7600Preparation of MED1(transcription mediator subunit) gene nanocarrier and its mechanism of action on liver cell regeneration in chronic acute liver failure
Guo_2021_Biomater.Sci__The facile formation of hierarchical mesoporous silica nanocarriers for tumor-selective multimodal theranostics
Guo_2021_Chemosphere_263_128270iTRAQ and PRM-based comparative proteomic profiling in gills of white shrimp Litopenaeus vannamei under copper stress
Guo_2021_Food.Res.Int_148_110587Complexation of caffeine and theophylline with epigallocatechin gallate in aqueous solution: Nuclear magnetic resonance, molecular docking and thermodynamics studies
Guo_2021_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1174_122722A strategy to discover selective alpha-glucosidase/acetylcholinesterase inhibitors from five function-similar citrus herbs through LC-Q-TOF-MS, bioassay and virtual screening
Guo_2021_J.Trace.Elem.Med.Biol_68_126844Protective effects of pretreatment with Fe(2+), Cu(2+), and Rb(+) on phoxim poisoning in silkworm, Bombyx mori
Guo_2021_Microorganisms_9_Characterization of Two Unique Cold-Active Lipases Derived from a Novel Deep-Sea Cold Seep Bacterium
Guo_2021_Nat.Prod.Res__1Total synthesis of (-)-brazilane via a lipase-catalyzed desymmetrisation reaction
Guo_2021_Open.Biol_11_210106ANGPTL8 in metabolic homeostasis: more friend than foe?
Guo_2021_Sci.Rep_11_16409NOTUM promotes thermogenic capacity and protects against diet-induced obesity in male mice
Guo_2021_Sci.Rep_11_18744Acute benzo[a]pyrene exposure induced oxidative stress, neurotoxicity and epigenetic change in blood clam Tegillarca granosa
Guo_2021_Sci.Rep_11_5428Bioinformatis analysis reveals possible molecular mechanism of PXR on regulating ulcerative colitis
Guo_2021_Sci.Total.Environ_789_147887Combined toxicity of micro/nano scale polystyrene plastics and ciprofloxacin to Corbicula fluminea in freshwater sediments
Guo_2021_Spectrochim.Acta.A.Mol.Biomol.Spectrosc_266_120412Determination of methomyl in grain using deep eutectic solvent-based extraction combined with fluorescence-based enzyme inhibition assays
Gupta_2021_Biochem.J__Rivastigmine attenuates the Alzheimer's disease related protein degradation and apoptotic neuronal death signaling
Gurdere_2021_In.Silico.Pharmacol_9_34ADME properties, bioactivity and molecular docking studies of 4-amino-chalcone derivatives: new analogues for the treatment of Alzheimer, glaucoma and epileptic diseases
Gurunathan_2021_Int.J.Nanomedicine_16_2849Palladium Nanoparticle-Induced Oxidative Stress, Endoplasmic Reticulum Stress, Apoptosis, and Immunomodulation Enhance the Biogenesis and Release of Exosome in Human Leukemia Monocytic Cells (THP-1)
Gurunathan_2021_Int.J.Nanomedicine_16_515Platinum Nanoparticles Enhance Exosome Release in Human Lung Epithelial Adenocarcinoma Cancer Cells (A549): Oxidative Stress and the Ceramide Pathway are Key Players
Gutbrod_2021_Phytochemistry_185_112684Fatty acid isoprenoid alcohol ester synthesis in fruits of the African Oil Palm (Elaeis guineensis)
Guzel_2021_J.Biochem.Mol.Toxicol__e22765Biologically active phthalocyanine metal complexes: Preparation, evaluation of alpha-glycosidase and anticholinesterase enzyme inhibition activities, and molecular docking studies
Gwozdzinski_2021_Cardiol.Res.Pract_2021_5569961Alterations in the Plasma and Red Blood Cell Properties in Patients with Varicose Vein: A Pilot Study
Ha_2021_Curr.Alzheimer.Res__Synthesis, Molecular Docking, and Biological Evaluation of Benzimidazole Derivatives as Selective Butyrylcholinesterase Inhibitors
Habib_2021_Food.Chem_364_130415Inhibitory effects of honey from arid land on some enzymes and protein damage
Hachisuka_2021_Appl.Environ.Microbiol__AEM0002021Development of a targeted gene disruption system in the PET-degrading bacterium Ideonella sakaiensis and its applications to PETase and MHETase genes
Hacioglu_2021_Biol.Trace.Elem.Res_199_3793Effects of Curcumin and Boric Acid Against Neurodegenerative Damage Induced by Amyloid Beta (1-42)
Hadda_2021_Med.Chem_17_834Spiro Heterocyclic Compounds as Potential Anti-Alzheimer Agents (Part 2): Their Metal Chelation Capacity, POM Analyses and DFT Studies
Hafez_2021_Mar.Drugs_19_Marine-Derived Compounds with Anti-Alzheimer's Disease Activities
Hafez_2021_Mol.Cell.Biochem__Ameliorative effects of astaxanthin on brain tissues of alzheimer's disease-like model: cross talk between neuronal-specific microRNA-124 and related pathways
Hagen_2021_PLoS.Pathog_17_e1009286Lentiviral transduction facilitates RNA interference in the nematode parasite Nippostrongylus brasiliensis
Haghighijoo_2021_Eur.J.Med.Chem_227_113949Therapeutic potential of quinazoline derivatives for Alzheimer's disease: A comprehensive review
Hagiwara-Nagasawa_2021_Naunyn.Schmiedebergs.Arch.Pharmacol_394_581Analysis of electropharmacological and proarrhythmic effects of donepezil using the halothane-anesthetized intact dogs and the conscious chronic atrioventricular block ones
Hajlaoui_2021_Molecules_26_Antimicrobial, Antioxidant, Anti-Acetylcholinesterase, Antidiabetic, and Pharmacokinetic Properties of Carum carvi L. and Coriandrum sativum L. Essential Oils Alone and in Combination
Hake_2021_Planta.Med__Alkaloids from Lime Flower (Tiliae flos) Exert Spasmodic Activity on Murine Airway Smooth Muscle Involving Acetylcholinesterase
Halder_2021_Front.Immunol_12_660342Cholinergic System and Its Therapeutic Importance in Inflammation and Autoimmunity
Halff_2021_Behav.Brain.Res__113203Effects of chronic exposure to haloperidol, olanzapine or lithium on SV2A and NLGN synaptic puncta in the rat frontal cortex
Halminen_2021_J.Alzheimers.Dis__Early Start of Anti-Dementia Medication Delays Transition to 24-Hour Care in Alzheimer's Disease Patients: A Finnish Nationwide Cohort Study
Hamdan_2021_Appl.Microbiol.Biotechnol__Thermostable lipases and their dynamics of improved enzymatic properties
Hamdeh_2021_Aliment.Pharmacol.Ther__Review article: drug-induced small bowel injury
Hameleers_2021_Biotechnol.Biofuels_14_127Polysaccharide utilization loci-driven enzyme discovery reveals BD-FAE: a bifunctional feruloyl and acetyl xylan esterase active on complex natural xylans
Hamiaux_2021_Methods.Mol.Biol_2309_233The Use of Differential Scanning Fluorimetry to Assess Strigolactone Receptor Function
Hamidi_2021_Environ.Sci.Pollut.Res.Int__Effect of petroleum wastewater treated with gravity separation and magnetite nanoparticles adsorption methods on the blood biochemical response of mrigal fish (Cirrhinus cirrhosus)
Hammid_2021_Mol.Pharm__Carboxylesterase Activities and Protein Expression in Rabbit and Pig Ocular Tissues
Hammock_2021_J.Med.Chem__Movement to the Clinic of Soluble Epoxide Hydrolase Inhibitor EC5026 as an Analgesic for Neuropathic Pain and for Use as a Nonaddictive Opioid Alternative
Hamoudi_2021_Comb.Chem.High.Throughput.Screen__Phytochemical screening, in vitro antioxidant and enzyme inhibitory proprieties and acute toxicity of extracts from the aerial parts of Ephedra nebrodensis, source of bioactive compounds
Hamulakova_2021_Future.Med.Chem__Design and synthesis of novel tacrine-indole hybrids as potential multitarget-directed ligands for the treatment of Alzheimer's disease
Han_2021_Acc.Chem.Res__Mechanistic Insight into the Design of Chemical Tools to Control Multiple Pathogenic Features in Alzheimer's Disease
Han_2021_Biochim.Biophys.Acta.Mol.Cell.Biol.Lipids_1866_158988Lipolysis and lipophagy play individual and interactive roles in regulating triacylglycerol and cholesterol homeostasis and mitochondrial form in zebrafish
Han_2021_Biotechnol.Lett__Surface charge engineering of Thermomyces lanuginosus lipase improves enzymatic activity and biodiesel synthesis
Han_2021_Diabetes.Obes.Metab_23_682Effectiveness and safety of sodium-glucose co-transporter-2 inhibitors compared with dipeptidyl peptidase-4 inhibitors in older adults with type 2 diabetes: A nationwide population-based study
Han_2021_Environ.Health.Perspect_129_77004A Roadmap to the Structure-Related Metabolism Pathways of Per- and Polyfluoroalkyl Substances in the Early Life Stages of Zebrafish (Danio rerio)
Han_2021_J.Asian.Nat.Prod.Res__1Citrinin and alpha-pyrone derivatives with pancreatic lipase inhibitory activities from Penicillium sp. SCSIO 41302
Han_2021_Mar.Drugs_19_Mixture of Phlorotannin and Fucoidan from Ecklonia cava Prevents the Abeta-Induced Cognitive Decline with Mitochondrial and Cholinergic Activation
Han_2021_Toxicol.Res_37_443No prominent toxicity of polyethylene microplastics observed in neonatal mice following intratracheal instillation to dams during gestational and neonatal period
Handl_2021_Chem.Res.Toxicol__Effects of Charged Oxime Reactivators on the HK-2 Cell Line in Renal Toxicity Screening
Hansen_2021_Thorax__Organophosphate and carbamate insecticide exposure is related to lung function change among smallholder farmers: a prospective study
Hanslik_2021_Sci.Total.Environ__151640Rethinking the relevance of microplastics as vector for anthropogenic contaminants: Adsorption of toxicants to microplastics during exposure in a highly polluted stream - Analytical quantification and assessment of toxic effects in zebrafish (Danio rerio)
Hao_2021_J.Med.Entomol__Transcriptome Analysis of Aedes albopictus (Diptera: Culicidae) Larvae Exposed With a Sublethal Dose of Haedoxan A
Hapeta_2021_Sci.Rep_11_6412A 37-amino acid loop in the Yarrowia lipolytica hexokinase impacts its activity and affinity and modulates gene expression
Harada_2021_Appl.Microbiol.Biotechnol__Carboxylesterases for the hydrolysis of acetoacetate esters and their applications in terpenoid production using Escherichia coli
Haris_2021_Acc.Chem.Res__Seeking Illumination: The Path to Chemiluminescent 1,2-Dioxetanes for Quantitative Measurements and In Vivo Imaging
Harthern-Flint_2021_Front.Microbiol_12_670928Experimental and Genomic Evaluation of the Oestrogen Degrading Bacterium Rhodococcus equi ATCC13557
Hartmann_2021_J.Med.Chem_64_2815Combined Cardioprotective and Adipocyte Browning Effects Promoted by the Eutomer of Dual sEH/PPARgamma Modulator
Hartz_2021_J.Biotechnol__Development and application of a highly efficient CRISPR-Cas9 system for genome engineering in Bacillus megaterium
Hasan_2021_Bioorg.Chem_119_105572Novel thiophene Chalcones-Coumarin as acetylcholinesterase inhibitors: Design, synthesis, biological evaluation, molecular docking, ADMET prediction and molecular dynamics simulation
Hashem_2021_Mol.Neurobiol__Inhibition of 2-Arachidonoylglycerol Metabolism Alleviates Neuropathology and Improves Cognitive Function in a Tau Mouse Model of Alzheimer's Disease
Hashemi_2021_Am.J.Med.Genet.A_185_440Clinical spectrum in multiple families with primary COQ(10) deficiency
Hassan_2021_Afr.Health.Sci_21_1124Insecticide resistance of Dengue vectors in South East Asia: a systematic review
Hassan_2021_Mol.Divers__New organosulfur metallic compounds as potent drugs: synthesis, molecular modeling, spectral, antimicrobial, drug likeness and DFT analysis
Hassan_2021_Pak.J.Pharm.Sci_34_47Neuroprotective and antioxidant effect of Curcuma longa (Rhizome) methanolic extract on SH-SY5Y cells and Javanese medaka
Hassan_2021_Phytomedicine_93_153771Health benefits and phenolic compounds of Moringa oleifera leaves: A comprehensive review
Hassanzadeh_2021_Res.Pharm.Sci_16_482Design, synthesis, and bio-evaluation of new isoindoline-1,3-dione derivatives as possible inhibitors of acetylcholinesterase
Hatori_2021_Anticancer.Res_41_3583Clinical Significance of PLA2G2A Expression in Gastric Cancer Patients who Receive Gastrectomy and Adjuvant S-1
Hauser-Davis_2021_Ecotoxicol.Environ.Saf_208_111589Biochemical metal accumulation effects and metalloprotein metal detoxification in environmentally exposed tropical Perna perna mussels
Hawkey_2021_Neurotoxicol.Teratol__106985Neurobehavioral anomalies in zebrafish after sequential exposures to DDT and chlorpyrifos in adulthood: Do multiple exposures interact?
Hayes_2021_Chem.Res.Toxicol_34_63Biological Distribution and Metabolic Profiles of Carbon-11 and Fluorine-18 Tracers of VX- and Sarin-Analogs in Sprague-Dawley Rats
Hayes_2021_Curr.Pharm.Des__Bioactive peptides in preventative healthcare: An overview of bioactivities and suggested methods to assess potential applications
He_2021_Anal.Chem__Bifunctional Moderator-Powered Ratiometric Electrochemiluminescence Enzymatic Biosensors for Detecting Organophosphorus Pesticides Based on Dual-Signal Combined Nanoprobes
He_2021_Bioprocess.Biosyst.Eng__High specific immobilization of His-tagged recombinant Microbacterium esterase by Ni-NTA magnetic chitosan microspheres for efficient synthesis of key chiral intermediate of d-biotin
He_2021_Cell.Death.Dis_12_992Deletion of soluble epoxide hydrolase suppressed chronic kidney disease-related vascular calcification by restoring Sirtuin 3 expression
He_2021_Chirality__Resolution of (R,S)-1-(4-methoxyphenyl)ethanol by lipase-catalyzed stereoselective transesterification and the process optimization
He_2021_Environ.Pollut_287_117649Toxicity of gabapentin-lactam on the early developmental stage of zebrafish (Danio rerio)
He_2021_Environ.Res_203_111902The relationship between pesticide exposure during critical neurodevelopment and autism spectrum disorder: A narrative review
He_2021_Free.Radic.Biol.Med_178_369Mitochondrial homeostasis and redox status in cardiovascular diseases: Protective role of the vagal system
He_2021_Int.J.Med.Mushrooms_23_71Caterpillar Medicinal Mushroom, Cordyceps militaris (Ascomycota), Attenuates Abeta1-42-Induced Amyloidogenesis and Inflammatory Response by Suppressing Amyloid Precursor Protein Progression and p38 MAPK/JNK Activation
He_2021_J.Mater.Chem.B__Near-infrared fluorescent probe for evaluating the acetylcholinesterase effect in the aging process and dietary restriction via fluorescence imaging
He_2021_Nucl.Med.Biol_96-97_S36Development of reversible monoacylglycerol lipase PET tracers with improved brain uptake
Hegde_2021_Genomics.Inform_19_e44Genetic analysis of the postsynaptic transmembrane X-linked neuroligin 3 gene in autism
Heier_2021_Elife_10_Hormone-sensitive lipase couples intergenerational sterol metabolism to reproductive success
Heinrich_2021_J.Gerontol.A.Biol.Sci.Med.Sci_76_1029Radiological, Chemical, and Pharmacological Cholinergic System Parameters and Neurocognitive Disorders in Older Presurgical Adults
Heise_2021_Eur.J.Med.Chem_227_113947N-methylated diazabicyclo[3.2.2]nonane substituted triterpenoic acids are excellent, hyperbolic and selective inhibitors for butyrylcholinesterase
Helal_2021_J.Genet.Eng.Biotechnol_19_1Lipase from Rhizopus oryzae R1: in-depth characterization, immobilization, and evaluation in biodiesel production
Helderman_2021_Bone__115946Loss of Function of Lysosomal Acid Lipase (LAL) Profoundly Impacts Osteoblastogenesis and Increases Fracture Risk in Humans
Hemaida_2021_ACS.Omega_6_19202Synthesis and Biological Evaluation of Thiazole-Based Derivatives as Potential Acetylcholinesterase Inhibitors
Her_2021_Br.J.Clin.Pharmacol__Effect of CES1 genetic variation on enalapril steady-state pharmacokinetics and pharmacodynamics in healthy subjects
Herceg_2021_Mar.Pollut.Bull_170_112654Fatty acids, persistent organic pollutants, and trace elements in small pelagic fish from the eastern Mediterranean Sea
Hermansyah_2021_Comput.Biol.Chem_95_107597Virtual screening of dipeptidyl peptidase-4 inhibitors using quantitative structure-activity relationship-based artificial intelligence and molecular docking of hit compounds
Hernandez-Toledano_2021_Chem.Biol.Interact_346_109578The cytoskeleton as a non-cholinergic target of organophosphate compounds
Herr_2021_Drugs.Aging__Removal of Drugs for Alzheimer's Disease from the List of Reimbursable Drugs in France: Analysis of Change in Drug Use, Disease Management and Cognition Using the National Alzheimer Data Bank (BNA)
Herrera-Acevedo_2021_Mol.Divers__Machine learning models to select potential inhibitors of acetylcholinesterase activity from SistematX: a natural products database
Herrera-Moreno_2021_Environ.Sci.Pollut.Res.Int__Organophosphorus pesticide exposure biomarkers in a Mexican population
Herrera_2021_Prim.Care.Diabetes_15_323Cardiovascular events and mortality among type 2 diabetes mellitus patients newly prescribed first-line blood glucose-lowering drugs monotherapies: A population-based cohort study in the Catalan electronic medical record database, SIDIAP, 2010-2015
Herriage_2021_Toxicol.In.Vitro_78_105268Concentration-dependent effects of chlorpyrifos oxon on peroxisome proliferator-activated receptor signaling in MCF-7 cells
Hetrick_2021_ACS.Chem.Biol__Endogenous Enzymes Enable Antimicrobial Activity
Hewage_2021_Org.Lett__An Enzyme-Mediated Aza-Michael Addition Is Involved in the Biosynthesis of an Imidazoyl Hybrid Product of Conidiogenone B
Heyde_2021_Microb.Cell.Fact_20_93Surface display as a functional screening platform for detecting enzymes active on PET
Hilliou_2021_Insects_12_Resistance in the Genus Spodoptera: Key Insect Detoxification Genes
Hinkaew_2021_Molecules_26_A Comparison of the Nutritional and Biochemical Quality of Date Palm Fruits Obtained Using Different Planting Techniques
Hinkovska-Galcheva_2021_J.Lipid.Res_62_100089Inhibition of lysosomal phospholipase A2 predicts drug-induced phospholipidosis
Hirasawa_2021_J.Nat.Med__Cliniatines A-C, new Amaryllidaceae alkaloids from Clivia miniata, inhibiting Acetylcholinesterase
Hirata_2021_Mol.Biol.Cell__mbcE20070500Atg15 in Saccharomyces cerevisiae consists of two functionally distinct domains
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Kadowaki_2021_Diabetes.Obes.Metab__A Randomized, Placebo-controlled Study to Evaluate the Efficacy and Safety of Adding Omarigliptin to Insulin Therapy in Japanese Patients with Type 2 Diabetes and Inadequate Glycemic Control
Kahlert_2021_Angew.Chem.Int.Ed.Engl_60_11423Biosynthesis of 6-Hydroxymellein Requires a Collaborating Polyketide Synthase-like Enzyme
Kakamad_2021_Int.J.Surg.Case.Rep_85_106149Thymoma with osseous metaplasia; a case report with a brief literature review
Kalita_2021_Mol.Pharm_18_451Synthesis and Screening of alpha-Xylosides in Human Glioblastoma Cells
Kalyandurg_2021_Phytopathology__Spray-induced gene silencing as a potential tool to control potato late blight disease
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Kang_2021_Pharmaceutics_13_Co-Spray Dried Nafamostat Mesylate with Lecithin and Mannitol as Respirable Microparticles for Targeted Pulmonary Delivery: Pharmacokinetics and Lung Distribution in Rats
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Kumar_2021_Front.Pharmacol_12_737137Five-Decade Update on Chemopreventive and Other Pharmacological Potential of Kurarinone: a Natural Flavanone
Kumar_2021_Life.Sci__119115Pancreatic lipase inhibitors: The road voyaged and successes
Kumar_2021_Mar.Pollut.Bull_170_112682Metal determination and biochemical status of marine fishes facilitate the biomonitoring of marine pollution
Kumar_2021_Neurochem.Int_151_105217Arbutin attenuates monosodium L-glutamate induced neurotoxicity and cognitive dysfunction in rats
Kumar_2021_PLoS.One_16_e0258106Staphylococcus aureus Lipase 3 (SAL3) is a surface-associated lipase that hydrolyzes short chain fatty acids
Kumar_2021_Saudi.J.Biol.Sci_28_754Cholinesterase inhibitory activity of highly functionalized fluorinated spiropyrrolidine heterocyclic hybrids
Kumar_2021_Talanta_224_121906Pseudosterase activity-based specific detection of human serum albumin on gel
Kumar_2021_Ticks.Tick.Borne.Dis_12_101818Characterization of deltamethrin, cypermethrin, coumaphos and ivermectin resistance in populations of Rhipicephalus microplus in India and efficacy of an antitick natural formulation prepared from Ageratum conyzoides
Kumari_2021_Biomedicines_9_The Importance of Lipoprotein Lipase Regulation in Atherosclerosis
Kumari_2021_Future.Microbiol__The lipolytic activity of LipJ, a stress-induced enzyme, is regulated by its C-terminal adenylate cyclase domain
Kumawat_2021_J.Phys.Chem.B__Organoselenium Compounds as Acetylcholinesterase Inhibitors: Evidence and Mechanism of Mixed Inhibition
Kundo_2021_Biomed.Res.Int_2021_9154406Identification of Polyphenolics from Loranthus globosus as Potential Inhibitors of Cholinesterase and Oxidative Stress for Alzheimer's Disease Treatment
Kundrick_2021_Neurotoxicol_82_130Cannabidiol reduces soman-induced lethality and seizure severity in female plasma carboxylesterase knockout mice treated with midazolam
Kundu_2021_Drug.Dev.Ind.Pharm__1Potential alternatives to current cholinesterase inhibitors: An in silico drug repurposing approach
Kunkeaw_2021_Sci.Rep_11_23796Diplazium esculentum (Retz.) Sw. reduces BACE-1 activities and amyloid peptides accumulation in Drosophila models of Alzheimer's disease
Kunnaja_2021_Molecules_26_In Vitro Antioxidant Activity of Litsea martabanica Root Extract and Its Hepatoprotective Effect on Chlorpyrifos-Induced Toxicity in Rats
Kurach_2021_Int.J.Mol.Sci_22_Mechanisms of the Procognitive Effects of Xanthotoxin and Umbelliferone on LPS-Induced Amnesia in Mice
Kurt-Celep_2021_Food.Chem.Toxicol__112330Comprehensive evaluation of two Astragalus species (A. campylosema and A. hirsutus) based on biological, toxicological properties and chemical profiling
Kuschpel_2021_Neurology_97_964Reader Response: Long-term Effects of Cholinesterase Inhibitors on Cognitive Decline and Mortality
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Kuwahata_2021_Circ.Rep_3_115Effect of QT Prolongation in Patients Taking Cholinesterase Inhibitors (Donepezil) for Alzheimer's Disease
Kwon_2021_Acute.Crit.Care__Continuous renal replacement therapy increased plasma cholinesterase activity in a case of acute organophosphate poisoning
Labar_2021_Biomolecules_11_533Structure and Dynamics of an Archeal Monoglyceride Lipase from Palaeococcus ferrophilus as Revealed by Crystallography and In Silico Analysis
Labban_2021_Behav.Brain.Res__113100Effects of Melatonin and Resveratrol on Recognition Memory and Passive Avoidance Performance in a Mouse Model of Alzheimer's Disease
Lage-Vickers_2021_Commun.Biol_4_103The expression of YWHAZ and NDRG1 predicts aggressive outcome in human prostate cancer
Lagrutta_2021_Heliyon_7_e06539Nuclear-lipid-droplet proteome: carboxylesterase as a nuclear lipase involved in lipid-droplet homeostasis
Lai_2021_Front.Neural.Circuits_15_676891An Autism-Associated Neuroligin-3 Mutation Affects Developmental Synapse Elimination in the Cerebellum
Lajmanovich_2021_Sci.Total.Environ_804_150177Glyphosate and glufosinate ammonium, herbicides commonly used on genetically modified crops, and their interaction with microplastics: Ecotoxicity in anuran tadpoles
Lamb_2021_Environ.Sci.Process.Impacts__Towards a comprehensive understanding of malathion degradation: theoretical investigation of degradation pathways and related kinetics under alkaline conditions
Lambre_2021_EFSA.J_19_e06561Safety evaluation of the food enzyme triacylglycerol lipase from the genetically modified Aspergillus luchuensis strain FL100SC
Lambre_2021_EFSA.J_19_e07006Safety evaluation of the food enzyme rennet paste from the abomasum of suckling goats, lambs and calves
Lan_2021_J.Agric.Food.Chem__Structure-Guided Rational Design of a Mono- and Diacylglycerol Lipase from Aspergillus oryzae: A Single Residue Mutant Increases the Hydrolysis Ability
Lan_2021_J.Chem.Inf.Model__Glycerol is Released from a New Path in MGL Lipase Catalytic Process
Landete_2021_Int.J.Food.Sci.Nutr__1The use of Lactobacillus plantarum esterase genes: a biotechnological strategy to increase the bioavailability of dietary phenolic compounds in lactic acid bacteria
Lane_2021_BMC.Fam.Pract_22_51Primary care physician volume and quality of care for older adults with dementia: a retrospective cohort study
Lanzarin_2021_Biomedicines_9_Inflammatory, Oxidative Stress, and Apoptosis Effects in Zebrafish Larvae after Rapid Exposure to a Commercial Glyphosate Formulation
Latif_2021_Drug.Dev.Res_82_207New multitarget directed benzimidazole-2-thiol-based heterocycles as prospective anti-radical and anti-Alzheimer's agents
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Lazarova_2021_J.Alzheimers.Dis__Effects of New Galantamine Derivatives in a Scopolamine Model of Dementia in Mice
Lazarova_2021_J.Alzheimers.Dis__2New Galantamine Derivatives with Inhibitory Effect on Acetylcholinesterase Activity
Lazewska_2021_Molecules_26_Biphenylalkoxyamine Derivatives-Histamine H(3) Receptor Ligands with Butyrylcholinesterase Inhibitory Activity
Le Douce_2021_Front.Neurosci_15_651094Subcommissural Organ-Spondin-Derived Peptide Restores Memory in a Mouse Model of Alzheimer's Disease
Le Du-Carree_2021_Sci.Total.Environ_784_147162Immunological and metabolic effects of acute sublethal exposure to glyphosate or glyphosate-based herbicides on juvenile rainbow trout, Oncorhynchus mykiss
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Le_2021_FASEB.J_35_e21961Differential expression and hypoxia-mediated regulation of the N-myc downstream regulated gene family
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Lecoutey_2021_Molecules_26_Development of Novel Potential Pleiotropic Compounds of Interest in Alzheimer's Disease Treatment through Rigidification Strategy
Lee_2021_ACS.Nano__Imaging Strategy that Achieves Ultrahigh Contrast by Utilizing Differential Esterase Activity in Organs: Application in Early Detection of Pancreatic Cancer
Lee_2021_Adv.Exp.Med.Biol_1187_23Phospholipase Signaling in Breast Cancer
Lee_2021_Anim.Biosci_34_1029Application of lactic acid bacteria producing antifungal substance and carboxylesterase on whole crop rice silage with different dry matter
Lee_2021_Br.J.Pharmacol__Alternative Pain Management via Endocannabinoids in the Time of the Opioid Epidemic: Peripheral Neuromodulation and Pharmacological Interventions
Lee_2021_Cell.Rep.Phys.Sci_2_A self-degradable hydrogel sensor for a nerve agent tabun surrogate through a self-propagating cascade
Lee_2021_Eur.J.Clin.Pharmacol__Post-market utilization patterns of Alzheimer's disease treatments in South Korea: comparison with countries with universal health coverage
Lee_2021_Front.Physiol_12_643389Interactive Gene Expression Between Metarhizium anisopliae JEF-290 and Longhorned Tick Haemaphysalis longicornis at Early Stage of Infection
Lee_2021_Int.J.Biol.Macromol_190_441Mining of a novel esterase (est3S) gene from a cow rumen metagenomic library with organosphosphorus insecticides degrading capability: Catalytic insights by site directed mutations, docking, and molecular dynamic simulations
Lee_2021_J.Enzyme.Inhib.Med.Chem_36_437Pyridinium-2-carbaldoximes with quinolinium carboxamide moiety are simultaneous reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by nerve agent surrogates
Lee_2021_Molecules_26_Characterization and Study on Fragmentation Pathways of a Novel Nerve Agent, 'Novichok (A234)', in Aqueous Solution by Liquid Chromatography-Tandem Mass Spectrometry
Lee_2021_Nutrients_13_DW2009 Elevates the Efficacy of Donepezil against Cognitive Impairment in Mice
Lee_2021_Pharmaceutics_13_Assessments of the In Vitro and In Vivo Linker Stability and Catabolic Fate for the Ortho Hydroxy-Protected Aryl Sulfate Linker by Immuno-Affinity Capture Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometric Assay
Lei_2021_Microb.Cell.Fact_20_197Degradation of epigallocatechin and epicatechin gallates by a novel tannase Tan(Hcw) from Herbaspirillum camelliae
Leineweber_2021_J.Zoo.Wildl.Med_51_948Clinical chemistry, vitamin, electrophoresis, and hematologic analytes of black-headed ibis (Threskiornis melanocephalus)
Leitao_2021_Int.J.Mol.Sci_22_Structural Insights into Carboxylic Polyester-Degrading Enzymes and Their Functional Depolymerizing Neighbors
Leite_2021_Foods_10_Chemical Profile and Evaluation of the Antioxidant and Anti-Acetylcholinesterase Activities of Annona squamosa L. (Annonaceae) Extracts
Lemire_2021_Am.J.Hum.Genet__ABHD16A deficiency causes a complicated form of hereditary spastic paraplegia associated with intellectual disability and cerebral anomalies
Lemus_2021_J.Pain.Symptom.Manage__Sugammadex to reverse neuromuscular blockade prior to withdrawal of life support
Leng_2021_Nat.Rev.Neurol_17_157Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?
Leon_2021_S.Afr.J.Bot_136_91Alkaloids of Phaedranassa dubia (Kunth) J.F. Macbr. and Phaedranassa brevifolia Meerow (Amaryllidaceae) from Ecuador and its cholinesterase-inhibitory activity
Leonard_2021_J.Food.Sci__Effect of extrusion technology on hempseed (Cannabis sativa L.) oil cake: Polyphenol profile and biological activities
Les_2021_Biology.(Basel)_10_Jasonia glutinosa (L.) DC., a Traditional Herbal Tea, Exerts Antioxidant and Neuroprotective Properties in Different In Vitro and In Vivo Systems
Leth-Espensen_2021_Proc.Natl.Acad.Sci.U.S.A_118_e2026650118The intrinsic instability of the hydrolase domain of lipoprotein lipase facilitates its inactivation by ANGPTL4-catalyzed unfolding
Leung_2021_J.Neurochem_158_1236Cryo-electron microscopy of cholinesterases, present and future
Levano_2021_Mol.Genet.Genomic.Med_9_e1764Allelic and genotypic frequencies of NAT2, CYP2E1, and AADAC genes in a cohort of Peruvian tuberculosis patients
Levernier_2021_Chemistry_27_8782Phenyl Silicates with Substituted Catecholate Ligands: Synthesis, Structural Studies and Reactivity
Li-Beisson_2021_New.Phytol__The disassembly of lipid droplets in Chlamydomonas
Li_2021_Acta.Pharmacol.Sin__1Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain
Li_2021_Adv.Synth.Catal_362_4699Reprogramming Epoxide Hydrolase to Improve Enantioconvergence in Hydrolysis of Styrene Oxide Scaffolds
Li_2021_Anal.Chem_93_7362pH and Redox Dual-Response Disulfide Bond-Functionalized Red-Emitting Gold Nanoclusters for Monitoring the Contamination of Organophosphorus Pesticides in Foods
Li_2021_Anal.Chem_93_8161Profiling Active Enzymes for Polysorbate Degradation in Biotherapeutics by Activity-Based Protein Profiling
Li_2021_Anim.Biosci__mTOR and ERK1/2 signaling participate in the process of acetate regulating lipid metabolism and HSL expression
Li_2021_Ann.Thorac.Surg__Outcomes of juvenile myasthenia gravis: a comparison of robotic thymectomy with medication treatment
Li_2021_Antimicrob.Agents.Chemother__AAC0060221Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells
Li_2021_Appl.Biochem.Biotechnol__Enhanced Secretory Expression and Surface Display Level of Bombyx mori Acetylcholinesterase 2 by Pichia pastoris Based on Codon Optimization Strategy for Pesticides Setection
Li_2021_Biomacromolecules_22_2256Synthesis, Enzymatic Degradation, and Polymer-Miscibility Evaluation of Nonionic Antimicrobial Hyperbranched Polyesters with Indole or Isatin Functionalities
Li_2021_Bioorg.Chem_110_104826Inducing new bioactive metabolites production from coculture of Pestalotiopsis sp. and Penicillium bialowiezense
Li_2021_Cardiovasc.Drugs.Ther_35_877Impact of Peripheral alpha7-Nicotinic Acetylcholine Receptors on Cardioprotective Effects of Donepezil in Chronic Heart Failure Rats
Li_2021_Chem.Biol.Interact__109392Neuroprotective effects of protocatechuic acid on sodium arsenate induced toxicity in mice: Role of oxidative stress, inflammation, and apoptosis
Li_2021_Chem.Commun.(Camb)_57_8909A pendant droplet-based sensor for the detection of acetylcholinesterase and its inhibitors
Li_2021_Chemosphere_263_128238The association between toxic pesticide environmental exposure and Alzheimer's disease: A scientometric and visualization analysis
Li_2021_Chirality_33_62A novel lipase from Aspergillus oryzae WZ007 catalyzed synthesis of brivaracetam intermediate and its enzymatic characterization
Li_2021_Comb.Chem.High.Throughput.Screen_24_986Prognostic Significance of Hematopoietic-cell Serglycin for the Survival of Hepatocellular Carcinoma: A Single-center Retrospective Study
Li_2021_Commun.Biol_4_144Dipeptidyl peptidase 4 promotes peritoneal fibrosis and its inhibitions prevent failure of peritoneal dialysis
Li_2021_Comp.Biochem.Physiol.B.Biochem.Mol.Biol__110630Identification, characterization and mRNA transcript abundance profiles of the carboxylesterase (CXE5) gene in Eriocheir sinensis suggest that it may play a role in methyl farnesoate degradation
Li_2021_Data.Brief_36_107045Data for the lipase catalyzed synthesis of cyano-containing multi-substituted indoles
Li_2021_Drug.Des.Devel.Ther_15_1883Study on Hepatotoxicity of Rhubarb Based on Metabolomics and Network Pharmacology
Li_2021_Drug.Metab.Dispos__Contributions of Cathepsin A and Carboxylesterase 1 to the hydrolysis of Tenofovir Alafenamide in the Human Liver, and the Effect of CES1 Genetic Variation on Tenofovir Alafenamide Hydrolysis
Li_2021_Environ.Health.Perspect_129_47008Profiling the Tox21 Chemical Collection for Acetylcholinesterase Inhibition
Li_2021_Enzyme.Microb.Technol_144_109741Preparation of a Bombyx mori acetylcholinesterase enzyme reagent through chaperone protein disulfide isomerase co-expression strategy in Pichia pastoris for detection of pesticides
Li_2021_Eur.J.Med.Chem_225_113765Identification and structure-activity relationship exploration of uracil-based benzoic acid and ester derivatives as novel dipeptidyl Peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus
Li_2021_Eur.J.Med.Chem_229_114045The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression
Li_2021_Evid.Based.Complement.Alternat.Med_2021_7357521Enteral Nutrition Combined with Improved-Sijunzi Decoction Shows Positive Effect in Precachexia Cancer Patients: A Retrospective Analysis
Li_2021_Exp.Appl.Acarol__Acetylcholinesterase target sites for developing environmentally friendly insecticides against Tetranychus urticae (Acari: Tetranychidae)
Li_2021_Food.Chem_373_131285Molecular dynamics revealed the effect of epoxy group on triglyceride digestion
Li_2021_Food.Sci.Nutr_9_2349Extraction and purification of total flavonoids from Eupatorium lindleyanum DC. and evaluation of their antioxidant and enzyme inhibitory activities
Li_2021_Front.Aging.Neurosci_13_770948Electro-Acupuncture Improve the Early Pattern Separation in Alzheimer's Disease Mice via Basal Forebrain-Hippocampus Cholinergic Neural Circuit
Li_2021_Front.Cell.Dev.Biol_9_640667Structural and Functional Characterization of Fibronectin in Extracellular Vesicles From Hepatocytes
Li_2021_Front.Chem_9_713104A Multi-Catalytic Sensing for Hydrogen Peroxide, Glucose, and Organophosphorus Pesticides Based on Carbon Dots
Li_2021_Front.Oncol_11_679816Antidiabetic Agent DPP-4i Facilitates Murine Breast Cancer Metastasis by Oncogenic ROS-NRF2-HO-1 Axis via a Positive NRF2-HO-1 Feedback Loop
Li_2021_Int.Immunopharmacol_99_107920IL-6 downregulates hepatic carboxylesterases via NF-kappaB activation in dextran sulfate sodium-induced colitis
Li_2021_Int.J.Biol.Macromol_169_18Biological detoxification of fumonisin by a novel carboxylesterase from Sphingomonadales bacterium and its biochemical characterization
Li_2021_J.Agric.Food.Chem_69_5481A Highly Efficient Three-Liquid-Phase-Based Enzymatic One-Pot Multistep Reaction System with Recoverable Enzymes for the Synthesis of Biodiesel
Li_2021_J.Agric.Food.Chem_69_6087Inorganic Recognizer-Assisted Homogeneous Electrochemiluminescence Determination of Organophosphorus Pesticides via Target-Controlled Emitter Release
Li_2021_J.Asian.Nat.Prod.Res_24_88Bisabolanoic acid A, a new polychiral sesquiterpene with AChE inhibitory activity from a mangrove-derived fungus Colletotrichum sp
Li_2021_J.Asian.Nat.Prod.Res__1New 2-(2-Phenylethyl)chromone derivatives from agarwood originating from Aquilaria sinensis
Li_2021_J.Cancer.Res.Ther_17_644BCL6B hypermethylation predicts metastasis and poor prognosis in early-stage hepatocellular carcinoma after thermal ablation
Li_2021_J.Cell.Physiol_236_4435Reduced neuropathy target esterase in pre-eclampsia suppresses tube formation of HUVECs via dysregulation of phospholipid metabolism
Li_2021_J.Chromatogr.A_1663_462784Screening and identification of acetylcholinesterase inhibitors from Terminalia chebula fruits by immobilized enzyme on cellulose filter paper coupled with ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry and molecular docking
Li_2021_J.Clin.Invest__sEH promotes macrophage phagocytosis and lung clearance of Streptococcus pneumoniae
Li_2021_J.Food.Sci__Enzymatic acylation of rutin with benzoic acid ester and lipophilic, antiradical, and antiproliferative properties of the acylated derivatives
Li_2021_J.Med.Chem__Highly Potent and Selective Butyrylcholinesterase Inhibitors for Cognitive Improvement and Neuroprotection
Li_2021_J.Mol.Histol__Prednisolone induces osteocytes apoptosis by promoting Notum expression and inhibiting PI3K/AKT/GSK3beta/beta-catenin pathway
Li_2021_J.Pharm.Anal_11_183A dual-signal sensor for the analysis of parathion-methyl using silver nanoparticles modified with graphitic carbon nitride
Li_2021_Life.Sci_283_119866Morphine increases myocardial triacylglycerol through regulating adipose triglyceride lipase S406 phosphorylation
Li_2021_Medicine.(Baltimore)_100_e26662Effects of perioperative interventions for preventing postoperative delirium: A protocol for systematic review and meta-analysis of randomized controlled trials
Li_2021_Mikrochim.Acta_188_385A ratiometric fluorescence strategy based on inner filter effect for Cu(2+)-mediated detection of acetylcholinesterase
Li_2021_Molecules_26_Phytochemical Composition, Antioxidant Activity, and Enzyme Inhibitory Activities (alpha-Glucosidase, Xanthine Oxidase, and Acetylcholinesterase) of Musella lasiocarpa
Li_2021_Nat.Prod.Res_35_763(-)-Grandiflorimine, a new dibenzopyrrocoline alkaloid with cholinesterase inhibitory activity from Illigera grandiflora
Li_2021_Nat.Prod.Res__1A new diterpenoid alkaloid from Delphinium gyalanum C. Marquand & Airy Shaw
Li_2021_PLoS.One_16_e0247236Molecular dynamics investigation of the interaction between Colletotrichum capsici cutinase and berberine suggested a mechanism for reduced enzyme activity
Li_2021_Pestic.Biochem.Physiol_172_104769Biogenetic cantharidin is a promising leading compound to manage insecticide resistance of Mythimna separata (Lepidoptera: Noctuidae)
Li_2021_Pharmaceutics_13_Activation of Tenofovir Alafenamide and Sofosbuvir in the Human Lung and Its Implications in the Development of Nucleoside/Nucleotide Prodrugs for Treating SARS-CoV-2 Pulmonary Infection
Li_2021_Phytochem.Anal_32_640On-line coupling pressurised liquid extraction with two-dimensional counter current chromatography for isolation of natural acetylcholinesterase inhibitors from Astragalus membranaceus
Li_2021_Plant.J__Strigolactone mimic 2-nitrodebranone is highly active in Arabidopsis growth and development
Li_2021_SLAS.Discov__24725552211030897Identification of Compounds for Butyrylcholinesterase Inhibition
Li_2021_Sci.Rep_11_6913Characterization of a novel sn1,3 lipase from Ricinus communis L. suitable for production of oleic acid-palmitic acid-glycerol oleate
Li_2021_Stem.Cell.Res_53_102313A non-integrated iPSC line (SDQLCHi042-A) from a boy suffering from familial combined hyperlipidemia with compound heterozygous mutations of lipoprotein lipase gene
Li_2021_Zhen.Ci.Yan.Jiu_46_851[Acupuncture improves cognitive function of vascular dementia rats by regulating PI3K/Akt/mTOR pathway]
Liakath-Ali_2021_Front.Mol.Neurosci_14_659681The Perils of Navigating Activity-Dependent Alternative Splicing of Neurexins
Lian_2021_J.Lipid.Res__100093Carboxylesterase 1d (Ces1d) does not contribute to cholesteryl ester hydrolysis in the liver
Liang_2021_Biosens.Bioelectron_193_113553A novel biosensor based on multienzyme microcapsules constructed from covalent-organic framework
Liang_2021_J.Environ.Sci.Health.B__1Insecticidal and acetylcholine esterase inhibition activity of Rhododendron thymifolium essential oil and its main constituent against two stored product insects
Liao_2021_Genes.(Basel)_12_Functional Haplotype of LIPC Induces Triglyceride-Mediated Suppression of HDL-C Levels According to Genome-Wide Association Studies
Ligaj_2021_Talanta_223_121749Electrochemical screening of genoprotective and antioxidative effectiveness of Origanum vulgare L. and its functionality in the prevention of neurodegenerative disorders
Lillich_2021_J.Med.Chem_64_17259Structure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor gamma Agonists/Soluble Epoxide Hydrolase Inhibitors
Lim_2021_Int.J.Biol.Macromol_186_414Identification of regions affecting enzyme activity, substrate binding, dimer stabilization and polyhydroxyalkanoate (PHA) granule morphology in the PHA synthase of Aquitalea sp. USM4
Lim_2021_J.Inflamm.Res_14_6833Polymorphism rs10105606 of LPL as a Novel Risk Factor for Microalbuminuria
Lima_2021_Int.J.Biol.Macromol_167_1361Anti-acetylcholinesterase and toxicity against Artemia salina of chitosan microparticles loaded with essential oils of Cymbopogon flexuosus, Pelargonium x ssp and Copaifera officinalis
Lima_2021_J.Biomol.Struct.Dyn__1Diterpene Sonderianin isolated from Croton blanchetianus exhibits acetylcholinesterase inhibitory action and anxiolytic effect in adult zebrafish (Danio rerio) by 5-HT system
Limonta_2021_Comp.Biochem.Physiol.C.Toxicol.Pharmacol__109037Effects of microplastics on head kidney gene expression and enzymatic biomarkers in adult zebrafish
Lin_2021_ACS.Chem.Neurosci__Pharmacokinetic Approach to Combat the Synthetic Cannabinoid PB-22
Lin_2021_Exp.Ther.Med_21_548Curcumin relieves mice gastric emptying dysfunction induced by L-arginine and atropine through interstitial cells of Cajal
Lin_2021_Front.Pharmacol_12_754554Antioxidant Effects of Sophora davidi (Franch.) Skeels on d-Galactose-Induced Aging Model in Mice via Activating the SIRT1/p53 Pathway
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Lindgren_2021_J.Alzheimers.Dis__Differences in Dementia Care Between Swedish-Born and Foreign-Born from Countries with Different Country Level Socioeconomic Position: A Nationwide Register-Based Study
Liou_2021_Antioxidants.(Basel)_10_Oxidative Stress Biomarkers and Mitochondrial DNA Copy Number Associated with APOE4 Allele and Cholinesterase Inhibitor Therapy in Patients with Alzheimer's Disease
Lirio_2021_Dalton.Trans_50_1866Fast multipoint immobilization of lipase through chiral L-proline on a MOF as a chiral bioreactor
Lisboa_2021_Ecotoxicol.Environ.Saf_214_112049Ecotoxicological responses of Eisenia andrei exposed in field-contaminated soils by sanitary sewage
Liu_2021_Anal.Chim.Acta_1184_339026A BCNO QDs-MnO(2) nanosheets based fluorescence off-on-off and colorimetric sensor with smartphone detector for the detection of organophosphorus pesticides
Liu_2021_Analyst_145_7849Cu(2+)-Regulated reversible coordination interaction of GQD@Tb/GMP ICP nanoparticles: towards directly monitoring cerebrospinal acetylcholinesterase as a biomarker for cholinic brain dysfunction
Liu_2021_Aquat.Toxicol_242_106039Chlorogenic acid alleviates thioacetamide-induced toxicity and promotes liver development in zebrafish (Danio rerio) through the Wnt signaling pathway
Liu_2021_Arch.Insect.Biochem.Physiol__e21859Decreased carboxylesterase expression associated with increased susceptibility to insecticide in Mythimna separata
Liu_2021_Asian.J.Androl_23_109Clinical significance of EPHX2 deregulation in prostate cancer
Liu_2021_Biology.(Basel)_10_Enhancement of Fear Extinction Memory and Resistance to Age-Related Cognitive Decline in Butyrylcholinesterase Knockout Mice and (R)-Bambuterol Treated Mice
Liu_2021_Biomolecules_11_1552Identification and Biochemical Characterization of a Novel Hormone-Sensitive Lipase Family Esterase Est19 from the Antarctic Bacterium Pseudomonas sp. E2-15
Liu_2021_Bioresour.Technol_332_124967Directed evolution of feruloyl esterase from Lactobacillus acidophilus and its application for ferulic acid production
Liu_2021_Biosens.Bioelectron_199_113906Portable electrochemical biosensor based on laser-induced graphene and MnO(2) switch-bridged DNA signal amplification for sensitive detection of pesticide
Liu_2021_Biotechnol.Adv_48_107730Biodegradation and up-cycling of polyurethanes: Progress, challenges, and prospects
Liu_2021_Cancer.Chemother.Pharmacol__Carboxylesterase 1 polymorphisms are associated with clinical outcomes in gastroenteric cancer patients treated with capecitabine
Liu_2021_Catal.Sci.Technol__Reshaping the active pocket of esterase Est816 for resolution of economically important racemates
Liu_2021_Chem.Res.Toxicol__LC-MS/MS Analysis of the Formation and Loss of DNA Adducts in Rats Exposed to Vinyl Acetate Monomer through Inhalation
Liu_2021_Chemosphere_288_132492Reproductive stimulation and energy allocation variation of BDE-47 and its derivatives on Daphnia magna
Liu_2021_Enzyme.Microb.Technol_148_109818Synthesis of lipophilic arbutin ester by enzymatic transesterification in high pressure carbon dioxide
Liu_2021_Eur.J.Med.Chem_227_113973Design, synthesis, and biological evaluation of novel (4-(1,2,4-oxadiazol-5-yl)phenyl)-2-aminoacetamide derivatives as multifunctional agents for the treatment of Alzheimer's disease
Liu_2021_Eur.J.Med.Chem_229_114044Design, synthesis, and biological evaluation of carbamate derivatives of N-salicyloyl tryptamine as multifunctional agents for the treatment of Alzheimer's disease
Liu_2021_Eur.J.Med.Chem_229_114095Discovery of novel beta-carboline derivatives as selective AChE inhibitors with GSK-3beta inhibitory property for the treatment of Alzheimer's disease
Liu_2021_Eur.J.Pharm.Sci__105976Novel chrysin derivatives as hidden multifunctional agents for anti-Alzheimer's disease: design, synthesis and in vitro evaluation
Liu_2021_Food.Funct_12_144Isoleucine increases muscle mass through promoting myogenesis and intramyocellular fat deposition
Liu_2021_Food.Funct__Phlorizin exerts potent effects against aging induced by D-galactose in mice and PC12 cells
Liu_2021_Front.Bioeng.Biotechnol_9_697677Enhanced Production of (S)-2-arylpropionic Acids by Protein Engineering and Whole-Cell Catalysis
Liu_2021_Front.Cell.Dev.Biol_9_640867Inhibiting Monoacylglycerol Lipase Suppresses RANKL-Induced Osteoclastogenesis and Alleviates Ovariectomy-Induced Bone Loss
Liu_2021_Front.Neural.Circuits_15_638000Excitatory Impact of Dental Occlusion on Dorsal Motor Nucleus of Vagus
Liu_2021_Front.Pharmacol_12_794933The Mechanisms of Cucurbitacin E as a Neuroprotective and Memory-Enhancing Agent in a Cerebral Hypoperfusion Rat Model: Attenuation of Oxidative Stress, Inflammation, and Excitotoxicity
Liu_2021_Front.Pharmacol_12_818907Rivastigmine Regulates the HIF-1alpha/VEGF Signaling Pathway to Induce Angiogenesis and Improves the Survival of Random Flaps in Rats
Liu_2021_Front.Plant.Sci_12_720816Insecticidal Terpenes From the Essential Oils of Artemisia nakaii and Their Inhibitory Effects on Acetylcholinesterase
Liu_2021_Gastroenterology.Res_14_157Efficacy and Safety of Neostigmine and Decompressive Colonoscopy for Acute Colonic Pseudo-Obstruction: A Single-Center Analysis
Liu_2021_Handb.Clin.Neurol_179_175The diagonal band of Broca in health and disease
Liu_2021_Int.J.Mol.Sci_22_Association of TaD14-4D, a Gene Involved in Strigolactone Signaling, with Yield Contributing Traits in Wheat
Liu_2021_J.Biosci.Bioeng_131_225Selecting cells expressing high levels of recombinant proteins using the GPI-anchored protein with selenocysteine system
Liu_2021_J.Endocrinol_248_133Combined use of GABA and sitagliptin promotes human beta-cell proliferation and reduces apoptosis
Liu_2021_J.Med.Chem_64_13853Blood-Brain Barrier Permeable and NO-Releasing Multifunctional Nanoparticles for Alzheimer's Disease Treatment: Targeting NO/cGMP/CREB Signaling Pathways
Liu_2021_J.Nat.Med__Stilbenoids isolated from the roots of Rheum lhasaense under the guidance of the acetylcholinesterase inhibition activity
Liu_2021_J.Org.Chem__One-Step Synthesis of 4-Octyl Itaconate through the Structure Control of Lipase
Liu_2021_J.Pharm.Sci__Characterization of Polysorbate 80 by Liquid Chromatography-Mass Spectrometry to Understand Its Susceptibility to Degradation and Its Oxidative Degradation Pathway
Liu_2021_Mol.Immunol_140_70Trelagliptin ameliorates IL-1beta-impaired chondrocyte function via the AMPK/SOX-9 pathway
Liu_2021_Mol.Pharmacol__Tacrine induces endoplasmic reticulum-stressed apoptosis via disrupting the proper assembly of oligomeric acetylcholinesterase in cultured neuronal cells
Liu_2021_Mol.Pharmacol__2Construction and characterization of CRISPR/Cas9 knockout rat model of carboxylesterase 2a gene
Liu_2021_Molecules_26_Discovery of Guanidine Derivatives from Buthus martensii Karsch with Metal-Binding and Cholinesterase Inhibition Properties
Liu_2021_Nanoscale__Red-to-blue paper-based colorimetric sensor integrated with smartphone for point-of-use analysis of cerebral AChE upon Cd(2+) exposure
Liu_2021_Nat.Prod.Res__1Two new organic acids from Portulaca oleracea L. and their anti-inflammatory and anticholinesterase activities
Liu_2021_Neurotoxicol_82_82Dose- and time-related effects of acute diisopropylfluorophosphate intoxication on forced swim behavior and sucrose preference in rats
Liu_2021_Parasit.Vectors_14_450In vitro and in vivo efficacy of thiacloprid against Echinococcus multilocularis
Liu_2021_Pharmgenomics.Pers.Med_14_477The Impact of ABCB1 and CES1 Polymorphisms on Dabigatran Pharmacokinetics in Healthy Chinese Subjects
Liu_2021_Plant.Cell__An ABHD17-like hydrolase screening system to identify de-S-acylation enzymes of protein substrates in plant cells
Liu_2021_Plant.Foods.Hum.Nutr_76_105Chemical Constituents and their Antioxidant, Anti-Inflammatory and Anti-Acetylcholinesterase Activities from Pholidota cantonensis
Liu_2021_Plant.Foods.Hum.Nutr__Elsholtzia rugulosa: Phytochemical Profile and Antioxidant, Anti-Alzheimer's Disease, Antidiabetic, Antibacterial, Cytotoxic and Hepatoprotective Activities
Liu_2021_Rev.Esp.Enferm.Dig_113_524High expression of NDRG3 correlates with poor prognosis in gastric cancer patients
Liu_2021_Sci.Total.Environ__150681Avobenzone and nanoplastics affect the development of zebrafish nervous system and retinal system and inhibit their locomotor behavior
Liu_2021_Spectrochim.Acta.A.Mol.Biomol.Spectrosc__120665Monitoring of parathion methyl using a colorimetric gold nanoparticle-based acetylcholinesterase assay
Liu_2021_Toxins.(Basel)_13_874FumDSB Can Reduce the Toxic Effects of Fumonisin B(1) by Regulating Several Brain-Gut Peptides in Both the Hypothalamus and Jejunum of Growing Pigs
Lizama_2021_Antioxidants.(Basel)_10_Analysis of Carotenoids in Haloarchaea Species from Atacama Saline Lakes by High Resolution UHPLC-Q-Orbitrap-Mass Spectrometry: Antioxidant Potential and Biological Effect on Cell Viability
Lleo_2021_Alzheimers.Res.Ther_13_119VAMP-2 is a surrogate cerebrospinal fluid marker of Alzheimer-related cognitive impairment in adults with Down syndrome
Lobine_2021_Chem.Biodivers__Chemical Composition and Pharmacological Evaluation and of Toddalia asiatica (Rutaceae) Extracts and Essential Oil by in Vitro and in Silico Approaches
Loganathan_2021_Neurotoxicol__Astaxanthin-s-allyl cysteine diester against high glucose-induced neuronal toxicity in vitro and diabetes-associated cognitive decline in vivo: Effect on p53, oxidative stress and mitochondrial function
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Lopes_2021_RSC.Med.Chem_12_2001An overview on the synthesis of carbohydrate-based molecules with biological activity related to neurodegenerative diseases
Lopez-Canoa_2021_Europace_23_682Sex-related differences of fatty acid-binding protein 4 and leptin levels in atrial fibrillation
Lopez-Obando_2021_Plant.Cell__The Physcomitrium (Physcomitrella) patens PpKAI2L receptors for strigolactones and related compounds function via MAX2-dependent and independent pathways
Lopez_2021_Food.Funct__Neuroprotective and anxiolytic potential of green rooibos (Aspalathus linearis) polyphenolic extract
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Lourido_2021_Environ.Toxicol.Pharmacol__103783Lethal and sublethal effects of the emerging contaminant oxytetracycline on the embryo-larval development of Rhinella arenarum
Loving_2021_Cells_10_Lipoprotein Lipase Regulates Microglial Lipid Droplet Accumulation
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Lu_2021_Food.Sci.Nutr_9_2402The seed oil of Paeonia ludlowii ameliorates Abeta25-35-induced Alzheimer's disease in rats
Lu_2021_Front.Pharmacol_12_706762Gender Disparities in Anti-dementia Medication Use among Older Adults: Health Equity Considerations and Management of Alzheimer's Disease and Related Dementias
Lu_2021_Future.Med.Chem_13_1105Synthesis and activity of miconazole derivatives as dual BChE/IDO1 inhibitors for the treatment of Alzheimer's disease
Lu_2021_Future.Med.Chem_13_769Discovery, biological evaluation and molecular dynamic simulations of butyrylcholinesterase inhibitors through structure-based pharmacophore virtual screening
Lu_2021_Genes.(Basel)_12_E122A Novel Carboxylesterase Derived from a Compost Metagenome Exhibiting High Stability and Activity towards High Salinity
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Luan_2021_Ecotoxicol.Environ.Saf_220_112398Toxicologic effect and transcriptome analysis for short-term orally dosed enrofloxacin combined with two veterinary antimicrobials on rat liver
Lubbers_2021_Microb.Cell.Fact_20_151Vanillic acid and methoxyhydroquinone production from guaiacyl units and related aromatic compounds using Aspergillus niger cell factories
Luca_2021_Antioxidants.(Basel)_10_Insights into the Phytochemical and Multifunctional Biological Profile of Spices from the Genus Piper
Luedtke_2021_Crystals_11_1270Backbone Conformation Shifts in X-ray Structures of Human Acetylcholinesterase upon Covalent Organophosphate Inhibition
Luis_2021_J.Nanobiotechnology_19_163Ecotoxicity evaluation of polymeric nanoparticles loaded with ascorbic acid for fish nutrition in aquaculture
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Lum_2021_ACS.Chem.Neurosci__Protective Effect of Natural Products against Huntington's Disease: An Overview of Scientific Evidence and Understanding Their Mechanism of Action
Lumley_2021_Toxicol.Rep_8_896Soman-induced toxicity, cholinesterase inhibition and neuropathology in adult male Gttingen minipigs
Lund_2021_Molecules_26_7155ThermoSlope: A Software for Determining Thermodynamic Parameters from Single Steady-State Experiments
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Luo_2021_Aging.(Albany.NY)_13_20179Long non-coding RNA ABHD11-AS1 promotes colorectal cancer progression and invasion through targeting the integrin subunit alpha 5/focal adhesion kinase/phosphoinositide 3 kinase/Akt signaling pathway
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Luo_2021_Front.Mol.Neurosci_14_744845Postsynaptic Neuroligin-1 Mediates Presynaptic Endocytosis During Neuronal Activity
Luo_2021_Front.Pediatr_9_679342Mechanisms of Congenital Myasthenia Caused by Three Mutations in the COLQ Gene
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Lupi_2021_Insects_12_Combined Effects of Pesticides and Electromagnetic-Fields on Honeybees: Multi-Stress Exposure
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Ma_2021_Biomed.Chromatogr__e5077Dynamic changes in chemical compositions and anti-acetylcholinesterase activity associated with steaming process of stem-leaf saponins of Panax notoginseng
Ma_2021_Chin.J.Integr.Med_27_912Elemene Emulsion Injection Administration Reduces Neuropathic Pain by Inhibiting Astrocytic NDRG2 Expression within Spinal Dorsal Horn
Ma_2021_Environ.Microbiol_23_996An ultrahigh-throughput screening platform based on flow cytometric droplet sorting for mining novel enzymes from metagenomic libraries
Ma_2021_Insect.Mol.Biol__Juvenile hormone regulates the reproductive diapause through Methoprene-tolerant gene in Galeruca daurica
Ma_2021_J.Agric.Food.Chem__Design, Synthesis, and Study of the Insecticidal Activity of Novel Steroidal 1,3,4-Oxadiazoles
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Ma_2021_Mikrochim.Acta_188_392Point-of-care testing of butyrylcholinesterase activity through modulating the photothermal effect of cuprous oxide nanoparticles
Ma_2021_Mol.Immunol_141_108The protective effects of Omarigliptin against Lipopolysaccharide (LPS)- induced inflammatory response and expression of mucin 5AC (MUC5AC) in human bronchial epithelial cells
Ma_2021_Talanta_235_122798Magnetic covalent organic framework immobilized gold nanoparticles with high-efficiency catalytic performance for chemiluminescent detection of pesticide triazophos
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MacCormack_2021_Front.Bioeng.Biotechnol_9_689933Boron Oxide Nanoparticles Exhibit Minor, Species-Specific Acute Toxicity to North-Temperate and Amazonian Freshwater Fishes
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Macharoen_2021_Biotechnol.Bioeng_118_1431Production of recombinant butyrylcholinesterase from transgenic rice cell suspension cultures in a pilot-scale bioreactor
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Mafa_2021_AMB.Express_11_21Feruloyl esterase (FAE-1) sourced from a termite hindgut and GH10 xylanases synergy improves degradation of arabinoxylan
Magalhaes-Gomes_2021_Neurosci__Increasead cholinergic tone causes pre-synaptic neuromuscular degeneration and is associated with impaired diaphragm function
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Maggio_2021_Chemosphere_276_130120Neurotoxicity of chlorpyrifos and chlorpyrifos-oxon to Daphnia magna
Maglioni_2021_Cells_11_High-Content C. elegans Screen Identifies Natural Compounds Impacting Mitochondria-Lipid Homeostasis and Promoting Healthspan
Mahe_2021_Environ.Res__110784The countryside or the city: which environment is better for the honeybee?
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Malafaia_2021_J.Hazard.Mater__127873Shedding light on the impacts of gestational exposure to polystyrene nanoplastics on the reproductive performance of Poecilia reticulata female and on the biochemical response of embryos
Malafaia_2021_Sci.Total.Environ_783_146994Green toxicology approach involving polylactic acid biomicroplastics and neotropical tadpoles: (Eco)toxicological safety or environmental hazard?
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Malgas_2021_Molecules_26_Unraveling Synergism between Various GH Family Xylanases and Debranching Enzymes during Hetero-Xylan Degradation
Malik_2021_Mol.Divers__ABCpred: a webserver for the discovery of acetyl- and butyryl-cholinesterase inhibitors
Maliszewski_2021_Molecules_26_1,3,5-Triazine Nitrogen Mustards with Different Peptide Group as Innovative Candidates for AChE and BACE1 Inhibitors
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Mandic_2021_PLoS.One_16_e0246810Chemical characterization and in vitro immunomodulatory effects of different extracts of moss Hedwigia ciliata (Hedw.) P. Beauv. from the Vrake Planine Mts., Serbia
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Mang'era_2021_Parasit.Vectors_14_1Transcriptomic response of Anopheles gambiae sensu stricto mosquito larvae to Curry tree (Murraya koenigii) phytochemicals
Mangiagalli_2021_Int.J.Biol.Macromol_181_263The activity and stability of a cold-active acylaminoacyl peptidase rely on its dimerization by domain swapping
Mangmool_2021_Molecules_26_Antioxidant and Anticholinesterase Activities of Extracts and Phytochemicals of Syzygium antisepticum Leaves
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Mansinhos_2021_Antioxidants.(Basel)_10_Ultrasonic-Assisted Extraction and Natural Deep Eutectic Solvents Combination: A Green Strategy to Improve the Recovery of Phenolic Compounds from Lavandula pedunculata subsp. lusitanica (Chaytor) Franco
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Marinho_2021_Fish.Physiol.Biochem__Toxicity of silver nanoparticles on different tissues in adult Danio rerio
Marins_2021_Ecotoxicology_30_164A mixture of pesticides at environmental concentrations induces oxidative stress and cholinergic effects in the neotropical fish Rhamdia quelen
Marins_2021_Ecotoxicology__Environmentally relevant pesticides induce biochemical changes in Nile tilapia (Oreochromis niloticus)
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Markova_2021_Toxics_9_Synthesis and Decontamination Effect on Chemical and Biological Agents of Benzoxonium-Like Salts
Marques_2021_ACS.Appl.Bio.Mater_4_8456Dip-and-Fold Device: A Paper-Based Testing Platform for Rapid Assessment of Insecticides in Water Samples
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Marsillach_2021_Antioxidants.(Basel)_10_Paraoxonase-1 and Other HDL Accessory Proteins in Neurological Diseases
Martelli_2021_Front.Genet_12_720552hGATA1 Under the Control of a LCR/beta-Globin Promoter Rescues the Erythroid but Not the Megakaryocytic Phenotype Induced by the Gata1 (low) Mutation in Mice
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Martinez-Alvarez_2021_Sci.Total.Environ_775_145669Uptake and effects of graphene oxide nanomaterials alone and in combination with polycyclic aromatic hydrocarbons in zebrafish
Martinez-Galan_2021_Food.Res.Int_148_110602Enzymatic synthesis of capric acid-rich structured lipids and their effects on mice with high-fat diet-induced obesity
Martinez_2021_Environ.Sci.Pollut.Res.Int__Comparison of biomarker responses after acute and chronic bioassays in Lumbriculus variegatus
Martini_2021_Neurocrit.Care__A Double-Blind, Randomized, Placebo-Controlled Trial of Soluble Epoxide Hydrolase Inhibition in Patients with Aneurysmal Subarachnoid Hemorrhage
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Masaryk_2021_Dalton.Trans__Unexpected solution behaviour of ester-functionalized half-sandwich Ru(II) and Ir(III) complexes
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Shcherbitskaia_2021_Cells_10_Prenatal Hyperhomocysteinemia Induces Glial Activation and Alters Neuroinflammatory Marker Expression in Infant Rat Hippocampus
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Silva_2021_Biology.(Basel)_10_Asparagopsis armata Exudate Cocktail: The Quest for the Mechanisms of Toxic Action of an Invasive Seaweed on Marine Invertebrates
Silva_2021_Bioorg.Chem_108_1046497-Amine-spiro[chromeno[4,3-b]quinoline-6,1'-cycloalkanes]: Synthesis and cholinesterase inhibitory activity of structurally modified tacrines
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Silva_2021_Environ.Toxicol.Chem_40_272Biomarker Responses of the Clam Ruditapes decussatus Exposed to a Complex Mixture of Environmental Stressors under the Influence of an Urban Wastewater-Treatment Plant
Silva_2021_Food.Chem.X_12_100171Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits
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Singh_2021_Chem.Res.Toxicol__New Alkoxy- Analogues of Epoxyeicosatrienoic Acids Attenuate Cisplatin Nephrotoxicity In Vitro via Reduction of Mitochondrial Dysfunction, Oxidative Stress, Mitogen-Activated Protein Kinase Signaling, and Caspase Activation
Singh_2021_Chemistry_27_5737Paraoxonase Mimic by a Nanoreactor Aggregate Containing Benzimidazolium Calix and l-Histidine: Demonstration of the Acetylcholine Esterase Activity
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Waseem_2021_ACS.Omega_6_7910Multispectroscopic and Molecular Docking Insight into Elucidating the Interaction of Irisin with Rivastigmine Tartrate: A Combinational Therapy Approach to Fight Alzheimer's Disease
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Watt_2021_BMJ_372_n532Comparative efficacy of interventions for reducing symptoms of depression in people with dementia: systematic review and network meta-analysis
Watts_2021_Future.Cardiol__Transcriptomic therapy for dyslipidemias utilizing nucleic acids targeted at ANGPTL3
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Wei_2021_ACS.Appl.Mater.Interfaces__A Lab-in-a-Syringe Device Integrated with a Smartphone Platform: Colorimetric and Fluorescent Dual-Mode Signals for On-Site Detection of Organophosphorus Pesticides
Wei_2021_Appl.Microbiol.Biotechnol__Metabolic engineering Yarrowia lipolytica for a dual biocatalytic system to produce fatty acid ethyl esters from renewable feedstock in situ and in one pot
Wei_2021_Chemosphere_270_128647Odorant degrading carboxylesterases modulate foraging and mating behaviors of Grapholita molesta
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Wei_2021_Fitoterapia__105090Structurally diverse Monascus pigments with hypolipidemic and hepatoprotective activities from highland barley Monascus
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Wei_2021_Phytochemistry_190_112867Euphorfinoids E-L: Diterpenoids from the roots of Euphorbia fischeriana with acetylcholinesterase inhibitory activity
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Wiley_2021_Front.Physiol_12_699712UPLC-MS/MS Method for Analysis of Endocannabinoid and Related Lipid Metabolism in Mouse Mucosal Tissue
Wilhelm_2021_Biochemistry_60_2560Kinetic and Structural Characterization of the Self-Labeling Protein Tags HaloTag7, SNAP-tag, and CLIP-tag
Wilkerson_2021_Pharmacol.Biochem.Behav__173192Untapped endocannabinoid pharmacological targets: pipe dream or pipeline?
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Wojdylo_2021_Sci.Rep_11_20253Comparison of bioactive compounds and health promoting properties of fruits and leaves of apple, pear and quince
Wolie_2021_Parasit.Vectors_14_581Evaluation of the interaction between insecticide resistance-associated genes and malaria transmission in Anopheles gambiae sensu lato in central Cte d'Ivoire
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Wu_2021_Eur.J.Neurosci__Inhibition of soluble epoxide hydrolase (sEH) protects hippocampal neurons and reduces cognitive decline in type 2 diabetic mice
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Wu_2021_Front.Plant.Sci_12_793459A Unique Sulfotransferase-Involving Strigolactone Biosynthetic Route in Sorghum
Wu_2021_Insects_12_Exposure of Helicoverpa armigera Larvae to Plant Volatile Organic Compounds Induces Cytochrome P450 Monooxygenases and Enhances Larval Tolerance to the Insecticide Methomyl
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Wu_2021_Org.Lett__Millmerranones A-F: A Meroterpene Cyclic Carbonate and Related Metabolites from the Australian Fungus Aspergillus sp. CMB-MRF324
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Wu_2021_Sci.Total.Environ__152285Biological responses of Eisenia fetida towards the exposure and metabolism of tris (2-butoxyethyl) phosphate
Wu_2021_Trends.Endocrinol.Metab_32_48Lipoprotein Lipase and Its Regulators: An Unfolding Story
Wullich_2021_Chembiochem_22_733Stabilizing AqdC, a Pseudomonas Quinolone Signal-Cleaving Dioxygenase from Mycobacteria, by FRESCO-Based Protein Engineering
Wurlitzer_2021_Appl.Environ.Microbiol_87_e02051Bacterial-Like Nonribosomal Peptide Synthetases Produce Cyclopeptides in the Zygomycetous Fungus Mortierella alpina
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Xia_2021_Anal.Sci_37_1023Peroxidase-mimicking Activity of PCN-222(Fe) for Colorimetric Sensing of Acetylcholinesterase Activity and Inhibition
Xia_2021_Ecotoxicol.Environ.Saf_218_112308Developmental neurotoxicity of antimony (Sb) in the early life stages of zebrafish
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Xiang_2021_Foods_10_UPLC-MS/MS Profiling, Antioxidant, alpha-Glucosidase Inhibitory, Cholinesterase Inhibitory, and Cardiovascular Protection Potentials of Jialing 20 (Morus multicaulis Perr.) Mulberry Branch Extract
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Xiao_2021_Biotechnol.Lett__An uncharacterized protein from the metagenome with no obvious homology to known lipases shows excellent alkaline lipase properties and potential applications in the detergent industry
Xiao_2021_Langmuir__Enzyme-Responsive Aqueous Two-Phase Systems in a Cationic-Anionic Surfactant Mixture
Xiao_2021_Talanta_221_121362A thiamine-triggered fluormetric assay for acetylcholinesterase activity and inhibitor screening based on oxidase-like activity of MnO(2) nanosheets
Xie_2021_Bioorg.Chem_109_104710Synthesis and biological evaluation of novel 8- substituted sampangine derivatives as potent inhibitor of Zn(2+)-Abeta complex mediated toxicity, oxidative stress and inflammation
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Xin_2021_Int.J.Mol.Sci_22_Catalytic Descriptors to Investigate Catalytic Power in the Reaction of Haloalkane Dehalogenase Enzyme with 1,2-Dichloroethane
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Xing_2021_Front.Microbiol_12_633489Gene Expression, Biochemical Characterization of a sn-1, 3 Extracellular Lipase From Aspergillus niger GZUF36 and Its Model-Structure Analysis
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Xiong_2021_Brain.Sci_11_Understanding the Modulatory Effects of Cannabidiol on Alzheimer's Disease
Xiong_2021_Nutrition_86_111155Vitamins A and D fail to protect against tuberculosis-drug-induced liver injury: A post hoc analysis of a previous randomized controlled trial
Xu_2021_3.Biotech_11_370Bioinformatics analysis of PAE family in Populus trichocarpa and responsiveness to carbon and nitrogen treatment
Xu_2021_Anal.Chem__Construction of Peroxidase-like Metal-Organic Frameworks in TiO(2) Nanochannels: Robust Free-Standing Membranes for Diverse Target Sensing
Xu_2021_BMC.Genomics_22_350Genome-wide analysis of the serine carboxypeptidase-like protein family in Triticum aestivum reveals TaSCPL184-6D is involved in abiotic stress response
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Xu_2021_Environ.Pollut_273_116461An efficient phthalate ester-degrading Bacillus subtilis: Degradation kinetics, metabolic pathway, and catalytic mechanism of the key enzyme
Xu_2021_Food.Chem_372_131256An efficient and robust continuous-flow bioreactor for the enzymatic preparation of phytosterol esters based on hollow lipase microarray
Xu_2021_J.Agric.Food.Chem_69_11554Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
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Xu_2021_J.Exp.Bot__Strigolactones regulate sepal senescence in Arabidopsis
Xu_2021_Microb.Cell.Fact_20_152The N-terminus of Lactobacillus amylovorus feruloyl esterase plays an important role in its secretion by Lactobacillus plantarum and Escherichia coli
Xu_2021_Nat.Chem__Catalytic reductive desymmetrization of malonic esters
Xu_2021_Nat.Plants_7_1495Catabolism of strigolactones by a carboxylesterase
Xu_2021_Neurology_97_965Author Response: Long-term Effects of Cholinesterase Inhibitors on Cognitive Decline and Mortality
Xu_2021_Neurology__Long Term Effects of Cholinesterase Inhibitors on Cognitive Decline and Mortality
Xu_2021_Pestic.Biochem.Physiol_179_104969Two single mutations in carboxylesterase 001C improve fenvalerate hydrolase activity in Helicoverpa armigera
Xu_2021_Sci.Rep_11_9450PbCSE1 promotes lignification during stone cell development in pear (Pyrus bretschneideri) fruit
Xuan_2021_ACS.Chem.Neurosci_12_2462Dimeric Tacrine(10)-hupyridone as a Multitarget-Directed Ligand To Treat Alzheimer's Disease
Xue_2021_CNS.Neurosci.Ther__Identification of a large homozygous SPG21 deletion in a Chinese patient with Mast syndrome
Xue_2021_Front.Bioeng.Biotechnol_9_762854Fusion of Chitin-Binding Domain From Chitinolyticbacter meiyuanensis SYBC-H1 to the Leaf-Branch Compost Cutinase for Enhanced PET Hydrolysis
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Yadav_2021_Clin.Chim.Acta_520_34Acute aluminum phosphide poisoning: The menace of phosphine exposure
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Yagishita-Kyo_2021_Biochem.Biophys.Res.Commun_551_54Testosterone interrupts binding of Neurexin and Neuroligin that are expressed in a highly socialized rodent, Octodon degus
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Yainna_2021_Insects_12_Geographic Monitoring of Insecticide Resistance Mutations in Native and Invasive Populations of the Fall Armyworm
Yamaga_2021_Nutrients_13_Acetylcholine and Royal Jelly Fatty Acid Combinations as Potential Dry Eye Treatment Components in Mice
Yamaguchi_2021_ACS.Appl.Bio.Mater_4_6512Paper-Based Analytical Device for the On-Site Detection of Nerve Agents
Yamamoto_2021_Plant.Signal.Behav__1961062Identification and molecular characterization of propionylcholinesterase, a novel pseudocholinesterase in rice
Yamasaki_2021_Intern.Med__Two Lambert-Eaton Myasthenic Syndrome Patients with Ameliorated Activities of Daily Living Due to Cholinesterase Inhibitors
Yamasaki_2021_Theranostics_11_9492Neuroprotective effects of minocycline and KML29, a potent inhibitor of monoacylglycerol lipase, in an experimental stroke model: a small-animal positron emission tomography study
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Yan_2021_Anim.Dis_1_15The nucleoside antiviral prodrug remdesivir in treating COVID-19 and beyond with interspecies significance
Yan_2021_Appl.Microbiol.Biotechnol__Synergistic biodegradation of poly(ethylene terephthalate) using Microbacterium oleivorans and Thermobifida fusca cutinase
Yan_2021_Arch.Microbiol__Identification and characterization of a novel carboxylesterase EstQ7 from a soil metagenomic library
Yan_2021_Cell.Mol.Life.Sci__Silencing the triacylglycerol lipase (TGL) gene decreases the number of apyrene sperm and inhibits oviposition in Sitotroga cerealella
Yan_2021_Environ.Sci.Technol__Comprehensive Interrogation on Acetylcholinesterase Inhibition by Ionic Liquids Using Machine Learning and Molecular Modeling
Yan_2021_Genome.Biol.Evol__A highly contiguous genome assembly of a polyphagous predatory mite Stratiolaelaps scimitus (Womersley) (Acari: Laelapidae)
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Yan_2021_Sci.Total.Environ_785_147260Characterization of a novel carboxylesterase with catalytic activity toward di(2-ethylhexyl) phthalate from a soil metagenomic library
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Yang_2021_Arch.Oral.Biol_130_105211Notum suppresses the osteogenic differentiation of periodontal ligament stem cells through the Wnt/Beta catenin signaling pathway
Yang_2021_Arch.Toxicol__Thifluzamide exposure induced neuro-endocrine disrupting effects in zebrafish (Danio rerio)
Yang_2021_Bioorg.Med.Chem_37_116109Twin drug design, synthesis and evaluation of diosgenin derivatives as multitargeted agents for the treatment of vascular dementia
Yang_2021_Cardiovasc.Drugs.Ther_35_467Research Progress on the Involvement of ANGPTL4 and Loss-of-Function Variants in Lipid Metabolism and Coronary Heart Disease: Is the Prime Time of ANGPTL4-Targeted Therapy for Coronary Heart Disease Approaching?
Yang_2021_Cell.J_23_355Neuroprotective Effects of Isoquercetin: An In Vitro and In Vivo Study
Yang_2021_Cell.Mol.Biol.Lett_26_50Esterase D stabilizes FKBP25 to suppress mTORC1
Yang_2021_Chemosphere_275_129974Influence of suspended sediment on the bioavailability of benzophenone-3: Focus on accumulation and multi-biological effects in Daphnia magna
Yang_2021_Clin.Neuropharmacol__Muscle-Specific Tyrosine Kinase Antibody Positive Myasthenia Gravis With Peripheral Nerve Hyperexcitability: Case Report and Literature Review
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Yang_2021_Ecotoxicol.Environ.Saf_208_111700Molecular and behavioral responses of zebrafish embryos/larvae after sertraline exposure
Yang_2021_Eur.J.Pharmacol__173950A review on alpha-mangostin as a potential multi-target-directed ligand for Alzheimer's disease
Yang_2021_Exp.Ther.Med_22_1252Evidence-based complementary and alternative medicine bioinformatics approach through network pharmacology and molecular docking to determine the molecular mechanisms of Erjing pill in Alzheimer's disease
Yang_2021_Fitoterapia_153_104948A norbisabolane and an arabitol benzoate from Talaromyces marneffei, an endophytic fungus of Epilobium angustifolium
Yang_2021_Food.Chem_376_131906Ultrasmall Au nanoparticles modified 2D metalloporphyrinic metal-organic framework nanosheets with high peroxidase-like activity for colorimetric detection of organophosphorus pesticides
Yang_2021_Front.Pharmacol_12_647481Pyridostigmine Protects Against Diabetic Cardiomyopathy by Regulating Vagal Activity, Gut Microbiota, and Branched-Chain Amino Acid Catabolism in Diabetic Mice
Yang_2021_Int.J.Mol.Sci_22_Differential Effects of 17,18-EEQ and 19,20-EDP Combined with Soluble Epoxide Hydrolase Inhibitor t-TUCB on Diet-Induced Obesity in Mice
Yang_2021_J.Agric.Food.Chem__pH-Response Quantum Dots with Orange-Red Emission for Monitoring the Residue, Distribution, and Variation of an Organophosphorus Pesticide in an Agricultural Crop
Yang_2021_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1170_122599Rapid screening for natural lipase inhibitors from Alisma orientale combining high-performance thin-layer chromatography-bioautography with mass spectrometry
Yang_2021_J.Obstet.Gynaecol.Res__Dipeptidyl peptidase IV is required for endometrial carcinoma cell proliferation and tumorigenesis via the IL-6/STAT3 pathway
Yang_2021_Mar.Drugs_19_An In-Silico Comparative Study of Lipases from the Antarctic Psychrophilic Ciliate Euplotes focardii and the Mesophilic Congeneric Species Euplotes crassus: Insight into Molecular Cold-Adaptation
Yang_2021_Med.Sci.Monit_27_e928523Identification of NDRG Family Member 4 (NDRG4) and CDC28 Protein Kinase Regulatory Subunit 2 (CKS2) as Key Prognostic Genes in Adrenocortical Carcinoma by Transcriptomic Analysis
Yang_2021_Nanotechnology__A highly sensitive acetylcholinesterase electrochemical biosensor based on Au-Tb alloy nanospheres for determining organophosphate pesticides
Yang_2021_Nat.Prod.Res__1Stephtetrandrine A-D, bisbenzylisoquinoline alkaloids from Stephania tetrandra
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Yang_2021_Plant.Cell__Misregulation of MYB16 expression causes stomatal cluster formation by disrupting polarity during asymmetric cell divisions
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Yanxian_2021_Toxicology__152934Toxic effects of subacute exposure to acrylamide on motor endplates of the gastrocnemius in rats
Yao_2021_AMB.Express_11_38A novel esterase from a soil metagenomic library displaying a broad substrate range
Yao_2021_Czech.J.Genet.Plant.Breed__Isolation, sequencing of the HvnHID gene and its role in the purple-grain colour development in Tibetan hulless barley
Yao_2021_Front.Microbiol_12_743377A Valuable Product of Microbial Cell Factories: Microbial Lipase
Yao_2021_J.Med.Chem__Discovery of Novel Tacrine-Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer's Disease
Yao_2021_New.Phytol__Desmethyl butenolides are optimal ligands for karrikin receptor proteins
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Yasuda_2021_Drug.Metab.Pharmacokinet_39_100397Epicatechin gallate and epigallocatechin gallate are potent inhibitors of human arylacetamide deacetylase
Yasuno_2021_Int.J.Geriatr.Psychiatry__Significant effects of cholinesterase inhibitors on tau pathology in the Alzheimer's disease continuum: An in vivo positron emission tomography study
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Yavasoglu_2021_Pestic.Biochem.Physiol_171_104746The first implementation of allele-specific primers for detecting the knockdown and acetylcholinesterase target site mutations in malaria vector, Anopheles sacharovi
Ye_2021_Bioorg.Chem_111_104895Design, synthesis, and in vitro evaluation of 4-aminoalkyl-1(2H)-phthalazinones as potential multifunctional anti-Alzheimer's disease agents
Ye_2021_PeerJ_9_e10919Putative carboxylesterase gene identification and their expression patterns in Hyphantria cunea (Drury)
Ye_2021_Trop.Anim.Health.Prod_53_366Association analysis between FASN genotype and milk traits in Mediterranean buffalo and its expression among different buffalo tissues
Yeh_2021_Life.Sci_278_119574DBPR108, a novel dipeptidyl peptidase-4 inhibitor with antihyperglycemic activity
Yi_2021_Appl.Microbiol.Biotechnol_105_7757Characterization and structural analysis of a thermophilic GH11 xylanase from compost metatranscriptome
Yi_2021_Front.Physiol_12_674023Identification of Candidate Carboxylesterases Associated With Odorant Degradation in Holotrichia parallela Antennae Based on Transcriptome Analysis
Yigit_2021_Bioorg.Chem_120_105566Selenourea and thiourea derivatives of chiral and achiral enetetramines: Synthesis, characterization and enzyme inhibitory properties
Yilmaz_2021_J.Biomol.Struct.Dyn__1Unravelling the phenolic compound reserves, antioxidant and enzyme inhibitory activities of an endemic plant species, Achillea pseudoaleppica
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Yin_2021_Biotechnol.Lett__Expression and kinetic analysis of carboxylesterase LmCesA1 from Locusta migratoria
Yin_2021_J.Cell.Mol.Med__Adipose triglyceride lipase promotes the proliferation of colorectal cancer cells via enhancing the lipolytic pathway
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Yoneten_2021_Cancer.Biomark__Decreased serum levels of glycerol-3- phosphate dehydrogenase 1 and monoacylglycerol lipase act as diagnostic biomarkers for breast cancer
Yoo_2021_Curr.Issues.Mol.Biol_43_405Immature Persimmon Suppresses Amyloid Beta (Abeta) Mediated Cognitive Dysfunction via Tau Pathology in ICR Mice
Yoo_2021_Sci.Rep_11_17914Cacao powder supplementation attenuates oxidative stress, cholinergic impairment, and apoptosis in D-galactose-induced aging rat brain
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Yoon_2021_Medicine.(Baltimore)_100_e27252Cognitive decline according to amyloid uptake in patients with poststroke cognitive impairment
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Zara_2021_Molecules_27_Surface Interaction of Ionic Liquids: Stabilization of Polyethylene Terephthalate-Degrading Enzymes in Solution
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Zhang_2021_BMC.Cancer_21_1156Development and validation of genomic and epigenomic signatures associated with tumor immune microenvironment in hepatoblastoma
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Zhang_2021_Chembiochem__A bi-enzymatic cascade pathway towards optically pure FAHFAs
Zhang_2021_Chemistry_10_3106Chemical and Genetic Studies on the Formation of Pyrrolones During the Biosynthesis of Cytochalasans
Zhang_2021_Chemosphere_281_130791Effects of exogenous GR24 on biogas upgrading and nutrient removal by co-culturing microalgae with fungi under mixed LED light wavelengths
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Zhang_2021_Front.Oncol_11_630257Clinical Relevance and Prognostic Value of the Neuronal Protein Neuroligin 2 in Breast Cancer
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Zhao_2021_Bioorg.Chem_108_104656Multivalent butyrylcholinesterase inhibitor discovered by exploiting dynamic combinatorial chemistry
Zhao_2021_Bioorg.Chem_116_105307Bioactive phenylpropanoid derivatives from the fruits of Lycium ruthenicum Murr
Zhao_2021_Bioorg.Chem_119_105520Identification and synthesis of selective cholesterol esterase inhibitor using dynamic combinatorial chemistry
Zhao_2021_Chem.Biol.Interact__109571Natural soluble epoxide hydrolase inhibitors from Inula britanica and their potential interactions with soluble epoxide hydrolase: Insight from inhibition kinetics and molecular dynamics
Zhao_2021_ChemMedChem_16_388Synthesis and Structure-Activity Relationships of 3-Arylisoquinolone Analogues as Highly Specific hCES2A Inhibitors
Zhao_2021_Chemosphere_279_130542Current insights into the microbial degradation for pyrethroids: strain safety, biochemical pathway, and genetic engineering
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Zhao_2021_Food.Chem_354_129511Detection of organophosphorus pesticides by nanogold/mercaptomethamidophos multi-residue electrochemical biosensor
Zhao_2021_Food.Funct__Neuroprotective effects of NDEELNK from sea cucumber ovum against scopolamine-induced PC12 cell damage through enhancing energy metabolism and upregulation of the PKA/BDNF/NGF signaling pathway
Zhao_2021_Front.Med.(Lausanne)_8_761517COX-2/sEH Dual Inhibitor PTUPB Alleviates CCl (4) -Induced Liver Fibrosis and Portal Hypertension
Zhao_2021_Future.Med.Chem__Small-molecule inhibitors of carboxylesterase Notum
Zhao_2021_Inorg.Chem__Loading and Sustained Release of Pralidoxime Chloride from Swellable MIL-88B(Fe) and Its Therapeutic Performance on Mice Poisoned by Neurotoxic Agents
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Zhao_2021_Int.J.Biol.Macromol__Characterization of a novel lipase from Bacillus licheniformis NCU CS-5 for applications in detergent industry and biodegradation of 2,4-D butyl ester
Zhao_2021_J.Chromatogr.A_1653_462443Development and characterization of a selective chromatographic approach to the rapid discovery of ligands binding to muscarinic-3 acetylcholine receptor
Zhao_2021_J.Dermatol.Sci_102_7Circular RNA circ_0079593 enhances malignant melanoma progression by the regulation of the miR-573/ABHD2 axis
Zhao_2021_J.Enzyme.Inhib.Med.Chem_36_248Production, purification and biochemical characterisation of a novel lipase from a newly identified lipolytic bacterium Staphylococcus caprae NCU S6
Zhao_2021_J.Med.Chem__Structural Insights into Notum Covalent Inhibition
Zhao_2021_J.Orthop.Surg.Res_16_364NDRG1 regulates osteosarcoma cells via mediating the mitochondrial function and CSCs differentiation
Zhao_2021_Mol.Metab__101201Notum Deacylates Octanoylated Ghrelin
Zhao_2021_Molecules_26_Chemical Composition and Biological Activities of Essential Oils from the Leaves, Stems, and Roots of Kadsura coccinea
Zhao_2021_Prog.Lipid.Res_83_101112Phosphatidylserine-specific phospholipase A1: A friend or the devil in disguise
Zhao_2021_Proteins__Mycobacterium tuberculosis puromycin hydrolase displays a prolyl oligopeptidase fold and an acyl aminopeptidase activity
Zhao_2021_Talanta_235_122784A near-infrared light triggered fluormetric biosensor for sensitive detection of acetylcholinesterase activity based on NaErF(4): 0.5 % Ho(3+)@NaYF(4) upconversion nano-probe
Zhao_2021_World.J.Microbiol.Biotechnol_37_212Characterization and genomic analysis of an efficient dibutyl phthalate degrading bacterium Microbacterium sp. USTB-Y
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Zheleva-Dimitrova_2021_Plants.(Basel)_10_Innovative Biochemometric Approach to the Metabolite and Biological Profiling of the Balkan Thistle (Cirsium appendiculatum Griseb.), Asteraceae
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Zheng_2021_Carbohydr.Polym_253_117255Metabolic degradation of lentinan in liver mediated by CYP450 enzymes and epoxide hydrolase
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Zhong-Johnson_2021_Sci.Rep_11_928An absorbance method for analysis of enzymatic degradation kinetics of poly(ethylene terephthalate) films
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Zhou_2021_Biomacromolecules__Synthesis, Characterization, and Simulation of Four-Armed Megamolecules
Zhou_2021_Biomarkers__1Cholinesterase homozygous genotype as susceptible biomarker of hypertriglyceridemia for pesticide-exposed agricultural workers
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Zhou_2021_Biosens.Bioelectron_196_113723Dual-fiber optic bioprobe system for triglyceride detection using surface plasmon resonance sensing and lipase-immobilized magnetic bead hydrolysis
Zhou_2021_Biotechnol.Biofuels_14_156Magnetic COFs as satisfied support for lipase immobilization and recovery to effectively achieve the production of biodiesel by great maintenance of enzyme activity
Zhou_2021_Chem.Biol.Drug.Des_98_997Synthesis and activities of acetylcholinesterase inhibitors
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Zhou_2021_Clin.Transl.Med_11_e449Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1
Zhou_2021_Front.Immunol_12_670427Pig Liver Esterases Hydrolyze Endocannabinoids and Promote Inflammatory Response
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Zhou_2021_Neuroreport_32_727Poria cocos polysaccharide attenuates damage of nervus in Alzheimer's disease rat model induced by D-galactose and aluminum trichloride
Zhu_2021_Appl.Microbiol.Biotechnol__Effect of cross-linked enzyme aggregate strategy on characterization of sn-1,3 extracellular lipase from Aspergillus niger GZUF36
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Zhu_2021_Front.Genet_12_693538Structure and Function of Pancreatic Lipase-Related Protein 2 and Its Relationship With Pathological States
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Zhu_2021_J.Biosci.Bioeng__Combining fermentation to produce O-succinyl-l-homoserine and enzyme catalysis for the synthesis of l-methionine in one pot
Zhu_2021_Molecules_26_Chemical Constituents from the Wild Atractylodes macrocephala Koidz and Acetylcholinesterase Inhibitory Activity Evaluation as Well as Molecular Docking Study
Zhu_2021_Pharmacol.Biochem.Behav__173209Donepezil prevents morphine tolerance by regulating N-methyl-d-aspartate receptor, protein kinase C and CaM-dependent kinase II expression in rats
Zhu_2021_Trials_22_688Efficiency of donepezil in elderly patients undergoing orthopaedic surgery due to underlying post-operative cognitive dysfunction: study protocol for a multicentre randomised controlled trial
Zilbeyaz_2021_Bioorg.Med.Chem_40_116194Design and synthesis of garlic-related unsymmetrical thiosulfonates as potential Alzheimer's disease therapeutics: In vitro and in silico study
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