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human-BCHE

Homo sapiens (Human) butyrylcholinesterase

Comment

Acylcholine acylhydrolase, Butyrylcholine esterase, Choline esterase II, Pseudocholinesterase. Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics.Various autosomal recessive mutations of the gene exist in human population || Another short contig contains a little bit of the gene AC069210.7.15194.32648 || Cterminus T peptide

Relationship

Family : BCHE

Block : C

Position in NCBI Life Tree : Homo sapiens

Molecular evidence

No mutation

Acetylcholine_WT_human-BCHE Acetylcholine_D70G_human-BCHE Propionylcholine_WT_human-BCHE Propionylcholine_D70G_human-BCHE Butyrylcholine_WT_human-BCHE Butyrylcholine_D70G_human-BCHE Pentanoylcholine_WT_human-BCHE Pentanoylcholine_D70G_human-BCHE Hexanoylcholine_WT_human-BCHE Hexanoylcholine_D70G_human-BCHE Heptanoylcholine_WT_human-BCHE Heptanoylcholine_D70G_human-BCHE Benzoylcholine_WT_human-BCHE Benzoylcholine_D70G_human-BCHE Succinyldithiocholine_WT_human-BCHE Succinyldithiocholine_D70G_human-BCHE Heroin_WT_human-BCHE Heroin_D70G_human-BCHE Procaine_WT_human-BCHE Procaine_D70G_human-BCHE Tetracaine_WT_human-BCHE Tetracaine_D70G_human-BCHE O-Nitrophenylbutyrate_WT_human-BCHE O-Nitrophenylbutyrate_D70G_human-BCHE 1-Naphtylacetate_WT_human-BCHE 1-Naphtylacetate_D70G_human-BCHE Methylprednisolone-acetate_WT_human-BCHE Methylprednisolone-acetate_D70G_human-BCHE Aspirin_WT_human-BCHE Aspirin_D70G_human-BCHE Choline_WT_human-BCHE Choline_D70G_human-BCHE Tetramethylammonium_WT_human-BCHE Tetramethylammonium_D70G_human-BCHE Meperidine_WT_human-BCHE Meperidine_D70G_human-BCHE Succinylcholine~Suxamethonium_WT_human-BCHE Succinylcholine~Suxamethonium_D70G_human-BCHE Decamethonium_WT_human-BCHE Decamethonium_D70G_human-BCHE Chlorpromazine_WT_human-BCHE Chlorpromazine_D70G_human-BCHE Dibucaine_WT_human-BCHE Dibucaine_D70G_human-BCHE Win5303_WT_human-BCHE Win5303_D70G_human-BCHE Win4510_WT_human-BCHE Win4510_human-BCHE Vecuronium_WT_human-BCHE Vecuronium_D70G_human-BCHE Pancuronium_WT_human-BCHE Pancuronium_D70G_human-BCHE 17-desoxypancuronium_WT_human-BCHE 17-desoxypancuronium_D70G_human-BCHE Neostigmine~Prostigmine_WT_human-BCHE Neostigmine~Prostigmine_D70G_human-BCHE Dibutyrate-pancuronium_WT_human-BCHE Dibutyrate-pancuronium_D70G_human-BCHE Physostigmine~Eserine_WT_human-BCHE Physostigmine~Eserine_D70G_human-BCHE Ro-2-0683_WT_human-BCHE Ro-2-0683_D70G_human-BCHE Bambuterol_WT_human-BCHE Paraoxon_G117H_human-BCHE Butyrylthiocholine_WT_human-BCHE Butyrylthiocholine_F525X_human-BCHE Benzoylcholine_F525X_human-BCHE O-Nitrophenylbutyrate_F525X_human-BCHE Butyrylthiocholine_L286K_human-BCHE Butyrylthiocholine_L286Q_human-BCHE Butyrylthiocholine_L286R_human-BCHE Butyrylthiocholine_L286D_human-BCHE Butyrylthiocholine_F329Q_human-BCHE Butyrylthiocholine_F329L_human-BCHE Butyrylthiocholine_F329C_human-BCHE Butyrylthiocholine_F329D_human-BCHE Butyrylthiocholine_Y440D_human-BCHE Echothiophate_WT_human-BCHE Echothiophate_L286K_human-BCHE Echothiophate_L286Q_human-BCHE Echothiophate_L286D_human-BCHE Echothiophate_F329Q_human-BCHE Echothiophate_F329L_human-BCHE Echothiophate_F329C_human-BCHE Echothiophate_F329D_human-BCHE Echothiophate_Y440D_human-BCHE Iso-OMPA_WT_human-BCHE Iso-OMPA_L286K_human-BCHE Iso-OMPA_L286Q_human-BCHE Iso-OMPA_L286D_human-BCHE Iso-OMPA_F329Q_human-BCHE Iso-OMPA_F329L_human-BCHE Iso-OMPA_F329C_human-BCHE Iso-OMPA_F329D_human-BCHE Iso-OMPA_Y440D_human-BCHE DFP_WT_human-BCHE DFP_L286Q_human-BCHE DFP_L286D_human-BCHE DFP_F329Q_human-BCHE DFP_F329L_human-BCHE DFP_F329C_human-BCHE DFP_F329D_human-BCHE DFP_Y440D_human-BCHE Butyrylthiocholine_D70G_human-BCHE Butyrylthiocholine_G115A_human-BCHE Butyrylthiocholine_G115S_human-BCHE Butyrylthiocholine_G115C_human-BCHE Butyrylthiocholine_G115D_human-BCHE Butyrylthiocholine_G115E_human-BCHE Butyrylthiocholine_G116E_human-BCHE Butyrylthiocholine_G117E_human-BCHE Butyrylthiocholine_G117D_human-BCHE Butyrylthiocholine_G116A\/G117D_human-BCHE Butyrylthiocholine_N68D_human-BCHE Butyrylthiocholine_N68K_human-BCHE Butyrylthiocholine_N68R_human-BCHE Butyrylthiocholine_N68Y_human-BCHE Butyrylthiocholine_N68A_human-BCHE Butyrylthiocholine_Q119A_human-BCHE Butyrylthiocholine_Q119E_human-BCHE Butyrylthiocholine_Q119G_human-BCHE Butyrylthiocholine_Q119H_human-BCHE Butyrylthiocholine_Q119K_human-BCHE Butyrylthiocholine_Q119R_human-BCHE Butyrylthiocholine_Q119Y_human-BCHE Butyrylthiocholine_T120E_human-BCHE Butyrylthiocholine_T120G_human-BCHE Butyrylthiocholine_T120H_human-BCHE Butyrylthiocholine_T120K_human-BCHE Butyrylthiocholine_W82Y_human-BCHE Butyrylthiocholine_W82F_human-BCHE Butyrylthiocholine_V127D_human-BCHE Tacrine_WT_human-BCHE Tacrine_D70G_human-BCHE Tacrine_N68D_human-BCHE Tacrine_N68K_human-BCHE Tacrine_N68R_human-BCHE Tacrine_N68Y_human-BCHE Tacrine_N68A_human-BCHE Tacrine_Q119A_human-BCHE Tacrine_Q119E_human-BCHE Tacrine_Q119G_human-BCHE Tacrine_Q119H_human-BCHE Tacrine_Q119K_human-BCHE Tacrine_Q119R_human-BCHE Tacrine_Q119Y_human-BCHE Tacrine_T120E_human-BCHE Tacrine_T120G_human-BCHE Tacrine_T120H_human-BCHE Tacrine_T120K_human-BCHE Tacrine_W82Y_human-BCHE Tacrine_W82F_human-BCHE Tacrine_G115A_human-BCHE Tacrine_G115S_human-BCHE Tacrine_G117E_human-BCHE Tacrine_V127D_human-BCHE Succinylcholine~Suxamethonium_N68D_human-BCHE Succinylcholine~Suxamethonium_N68K_human-BCHE Succinylcholine~Suxamethonium_N68R_human-BCHE Succinylcholine~Suxamethonium_N68Y_human-BCHE Succinylcholine~Suxamethonium_N68A_human-BCHE Succinylcholine~Suxamethonium_Q119A_human-BCHE Succinylcholine~Suxamethonium_Q119E_human-BCHE Succinylcholine~Suxamethonium_Q119G_human-BCHE Succinylcholine~Suxamethonium_Q119H_human-BCHE Succinylcholine~Suxamethonium_Q119K_human-BCHE Succinylcholine~Suxamethonium_Q119R_human-BCHE Succinylcholine~Suxamethonium_Q119Y_human-BCHE Succinylcholine~Suxamethonium_T120E_human-BCHE Succinylcholine~Suxamethonium_T120G_human-BCHE Succinylcholine~Suxamethonium_T120H_human-BCHE Succinylcholine~Suxamethonium_T120K_human-BCHE Succinylcholine~Suxamethonium_W82Y_human-BCHE Succinylcholine~Suxamethonium_W82F_human-BCHE Succinylcholine~Suxamethonium_G115A_human-BCHE Succinylcholine~Suxamethonium_G115S_human-BCHE Succinylcholine~Suxamethonium_G117E_human-BCHE Succinylcholine~Suxamethonium_V127D_human-BCHE Dibucaine_N68D_human-BCHE Dibucaine_N68K_human-BCHE Dibucaine_N68R_human-BCHE Dibucaine_N68Y_human-BCHE Dibucaine_N68A_human-BCHE Dibucaine_Q119A_human-BCHE Dibucaine_Q119E_human-BCHE Dibucaine_Q119G_human-BCHE Dibucaine_Q119H_human-BCHE Dibucaine_Q119K_human-BCHE Dibucaine_Q119R_human-BCHE Dibucaine_Q119Y_human-BCHE Dibucaine_T120E_human-BCHE Dibucaine_T120G_human-BCHE Dibucaine_T120H_human-BCHE Dibucaine_T120K_human-BCHE Dibucaine_W82Y_human-BCHE Dibucaine_W82F_human-BCHE Dibucaine_G115A_human-BCHE Dibucaine_G115S_human-BCHE Dibucaine_G117E_human-BCHE Dibucaine_V127D_human-BCHE Solanine_WT_human-BCHE Solanine_D70G_human-BCHE Solanine_N68D_human-BCHE Solanine_N68K_human-BCHE Solanine_N68R_human-BCHE Solanine_N68Y_human-BCHE Solanine_N68A_human-BCHE Solanine_Q119A_human-BCHE Solanine_Q119E_human-BCHE Solanine_Q119G_human-BCHE Solanine_Q119H_human-BCHE Solanine_Q119K_human-BCHE Solanine_Q119R_human-BCHE Solanine_Q119Y_human-BCHE Solanine_T120E_human-BCHE Solanine_T120G_human-BCHE Solanine_T120H_human-BCHE Solanine_T120K_human-BCHE Solanine_W82Y_human-BCHE Solanine_W82F_human-BCHE Solanine_G115A_human-BCHE Solanine_G115S_human-BCHE Solanine_G117E_human-BCHE Solanine_V127D_human-BCHE BW284C51_WT_human-BCHE BW284C51_D70G_human-BCHE BW284C51_N68D_human-BCHE BW284C51_N68K_human-BCHE BW284C51_N68R_human-BCHE BW284C51_N68Y_human-BCHE BW284C51_N68A_human-BCHE BW284C51_Q119A_human-BCHE BW284C51_Q119E_human-BCHE BW284C51_Q119G_human-BCHE BW284C51_Q119H_human-BCHE BW284C51_Q119K_human-BCHE BW284C51_Q119R_human-BCHE BW284C51_Q119Y_human-BCHE BW284C51_T120E_human-BCHE BW284C51_T120G_human-BCHE BW284C51_T120H_human-BCHE BW284C51_T120K_human-BCHE BW284C51_W82Y_human-BCHE BW284C51_W82F_human-BCHE BW284C51_G115A_human-BCHE BW284C51_G115S_human-BCHE BW284C51_G117E_human-BCHE BW284C51_V127D_human-BCHE Cocaine_WT_human-BCHE Cocaine_D70G_human-BCHE Cocaine_N68K_human-BCHE Cocaine_N68R_human-BCHE Cocaine_Q119K_human-BCHE Cocaine_Q119R_human-BCHE Cocaine_T120K_human-BCHE Cocaine_W82Y_human-BCHE Cocaine_W82F_human-BCHE Cocaine_G115A_human-BCHE Cocaine_G115S_human-BCHE Cocaine_G117E_human-BCHE Acetylthiocholine_WT_human-BCHE Edrophonium_WT_human-BCHE HuperzineA_WT_human-BCHE

No disease

6-(2-phenylethyl)-THAI-12b Aryl-carboxamide-benzoxazole-cpd36 DTNP BChE-HDAC6-IN-2 CHEMBL459756 FUB833 Piperidine-4-carboxamide-alkyl-tacrine-cpd16 Isosorbide-2-butylcarbamate-5-lipoic-acid-ester Tosyl-Octyl-2-aminobenzo-thiazole-6-carboxylate-cpd6k Chlorophenyl-methylsulfonyl-indol-acryloyl-phenyl-acetamide-cpd5b Benzylpiperidin-methylsulfonyl-indol-acryloyl-phenyl-acetamide-cpd6b Tacrine-Sibiriline-Cpd7 Tacrine-selegiline-8g Tacrine-selegiline-7d Di-tert-butyl-phenol-octylamino-cycloheptaquinolin-18d SB-1448 Indazole-derivative-4q Amiridine-thiouracil-13c CHEMBL4207101 8AM2-N0C Aminoalkyl-tetrahydropyrimido-azocine-7c 10c-Salicylimine-Tacrine tacrine-isatin-Cpd7d Indol-thioxotetrahydropyrimidine-Cpd7 Benzyloxy-benzylamino-Carltonine-Cpd28 Benzyloxy-benzylamino-Carltonine-Cpd33 Carltonine-A Carltonine-B N-demethylhuperzinine Caffeic-acid-phenethyl-ester ZINC59501712 CHEMBL4079247 C4I-7QHE C0I-7QHD 8UW-7Q1P 9CI-7Q1O 8IV-7Q1N 8IS-7Q1M Quinone-polyamine-NSAID-4 Propargyl-Tacrine-15 3,5-dihydroxybenzamido-huprine-hybrid-11 Donepezil-idebenone-cpd9 Benzimidazole-Diethylcarbamoyl-isopentyl-dimethylcarbamate-15d Benzimidazole-Ethoxybenzyl-isopentyl-azetidine-carboxylate-21d Benzimidazole-phenyl-azetidine-carboxylate-11d S17-1001 Aromatic-tertiary-amine-17c Tacrine-pentylmethylene-tolylsulfonamide Cpd-6-8AI7 N-10-Phenothiazine-1-Naphtyl-carbamate S11-1014 Coumarin-Pyridine-3f 6H6-Heptyl-Carbamate H327 BChE-IN-3 Cpd20-Benzimidazol-Oxadiazol S16-1029 Difluorophenyl-pyridin-piperazin-1,3,4-oxadiazole-49 5-pyrid-3-yl-1,3,4-oxadiazole-5e Salicylamide-8-Tacrine IA4-7BO3 A87-7BO4 MT-031 123I-PIP 8U2-7AIX7AY-compound5i CBD-carbamate-C16 PE154 S06-1011 Idalopirdine-rivastigmine Tacrine-methylanacardate-cpd5 5-deoxo-3-hydroxyevodiamine-heptyl-carbamate Tetracyclic-carbamate-cp8 Tetracyclic-carbamate-ferulicacid-4a N-alkyl-quinuclidine-cpd14 Pyranone-carbamate-cpd7p Tetracyclic-carbamate-UW-MD-95 6o-5-HT3 MTDL-cpd51-diphenylacetamide MTDL-cpd36-diphenylacetamide Ass-IN-10 1,9-dimethyl-methylene-blue 6ZWE-Cpd3 CHEMBL4454960 CHEMBL4454960-PET Tosyl-L-lysine-chloromethyl-ketone ZINC20166201-cpd8 8012-9656 6SAM-cpd13 Goodyschle-A 6EUL-BY2 6QAD-HUZ 6XTA-cpd18 6QAE-HUK 6QAC-HUT 6QAB-HUQ 6QAA-HUN 6RUA-3a JU5 JUB 6F7Q-cpd11 Chlorotacrine-tryptophan-hybrid PGN33 5LKR-6yc 5DYT-5hb 5DYY-5hh DL0410 5DYW-5hf-C11 5DYW-5hf-F 5DYW-5hf 5NN0-cpd3 Malachite-Green ST052207 Hup-19 Thioflavin-T Aroylacrylic-acid-amide-Tacrine-10 40V 3F9 VX-Biotin CBDP Dihydrobenzodioxepine-cymeserine (-)-phenethylcymserine 2-Chloroprocaine Dimethylhydroxycarbaphen Aprophen Choline Cocaine Decamethonium DFP Echothiophate Ethopropazine Fluoride Meperidine Mivacurium Toluidine-Blue Propidium Pyridostigmine Sarin Soman Tacrine Chinese-VX Russian-VX VX Isosorbide-2-benzylcarbamate-5-benzyl-ether Isosorbide-2-benzylcarbamate-5-benzoate Isosorbide-2-benzylcarbamate-5-salicylate

Database

Sequence

Peptide

EDDIIIATKN GKVRGMNLTV FGGTVTAFLG IPYAQPPLGR LRFKKPQSLT KWSDIWNATK YANSCCQNID QSFPGFHGSE MWNPNTDLSE DCLYLNVWIP APKPKNATVL IWIYGGGFQT GTSSLHVYDG KFLARVERVI VVSMNYRVGA LGFLALPGNP EAPGNMGLFD QQLALQWVQK NIAAFGGNPK SVTLFGESAG AASVSLHLLS PGSHSLFTRA ILQSGSFNAP WAVTSLYEAR NRTLNLAKLT GCSRENETEI IKCLRNKDPQ EILLNEAFVV PYGTPLSVNF GPTVDGDFLT DMPDILLELG QFKKTQILVG VNKDEGTAFL VYGAPGFSKD NNSIITRKEF QEGLKIFFPG VSEFGKESIL FHYTDWVDDQ RPENYREALG DVVGDYNFIC PALEFTKKFS EWGNNAFFYY FEHRSSKLPW PEWMGVMHGY EIEFVFGLPL ERRDNYTKAE EILSRSIVKR WANFAKYGNP NETQNNSTSW PVFKSTEQKY LTLNTESTRI MTKLRAQQCR FWTSFFPKVL EMTGNIDEAE WEWKAGFHRW NNYMMDWKNQ FNDYTSKKES CVGL

References

Title : Onset of Alzheimer disease in apolipoprotein sigma4 carriers is earlier in butyrylcholinesterase K variant carriers - Lane_2024_BMC.Neurol_24_116
Author(s) : Lane RM , Darreh-Shori T , Junge C , Li D , Yang Q , Edwards AL , Graham DL , Moore K , Mummery CJ
Ref : BMC Neurol , 24 :116 , 2024
Abstract : Lane_2024_BMC.Neurol_24_116
ESTHER : Lane_2024_BMC.Neurol_24_116
PubMedSearch : Lane_2024_BMC.Neurol_24_116
PubMedID: 38594621
Gene_locus related to this paper: human-BCHE

Title : Butyrylcholinesterase signal sequence self-aggregates and enhances amyloid fibril formation in vitro - Jasiecki_2023_Chem.Biol.Interact_14ChEPon_110783
Author(s) : Jasiecki J , Targonska M , Janaszak-Jasiecka A , Kalinowski L , Waleron K , Wasag B
Ref : Chemico-Biological Interactions , :110783 , 2023
Abstract : Jasiecki_2023_Chem.Biol.Interact_14ChEPon_110783
ESTHER : Jasiecki_2023_Chem.Biol.Interact_14ChEPon_110783
PubMedSearch : Jasiecki_2023_Chem.Biol.Interact_14ChEPon_110783
PubMedID: 37884182
Gene_locus related to this paper: human-BCHE

Title : Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids - Design, synthesis, and biological evaluation - Pidany_2023_Eur.J.Med.Chem_252_115301
Author(s) : Pidany F , Kroustkova J , Al Mamun A , Suchankova D , Brazzolotto X , Nachon F , Chantegreil F , Dolezal R , Pulkrabkova L , Muckova L , Hrabinova M , Finger V , Kufa M , Soukup O , Jun D , Jenco J , Kunes J , Novakova L , Korabecny J , Cahlikova L
Ref : Eur Journal of Medicinal Chemistry , 252 :115301 , 2023
Abstract : Pidany_2023_Eur.J.Med.Chem_252_115301
ESTHER : Pidany_2023_Eur.J.Med.Chem_252_115301
PubMedSearch : Pidany_2023_Eur.J.Med.Chem_252_115301
PubMedID: 36996715
Gene_locus related to this paper: human-BCHE

Title : Rapid discovery and crystallography study of highly potent and selective butylcholinesterase inhibitors based on oxime-containing libraries and conformational restriction strategies - Jing_2023_Bioorg.Chem_134_106465
Author(s) : Jing L , Wei W , Meng B , Chantegreil F , Nachon F , Martinez A , Wu G , Zhao H , Song Y , Kang D , Brazzolotto X , Zhan P , Liu X
Ref : Bioorg Chem , 134 :106465 , 2023
Abstract : Jing_2023_Bioorg.Chem_134_106465
ESTHER : Jing_2023_Bioorg.Chem_134_106465
PubMedSearch : Jing_2023_Bioorg.Chem_134_106465
PubMedID: 36933339
Gene_locus related to this paper: human-BCHE

Title : 8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases - Knez_2023_Acta.Pharmaceutica.Sinica.B_13_2152
Author(s) : Knez D , Diez-Iriepa D , Chioua M , Gottinger A , Denic M , Chantegreil F , Nachon F , Brazzolotto X , Skrzypczak-Wiercioch A , Meden A , Pislar A , Kos J , Zakelj S , Stojan J , Salat K , Serrano J , Patricia Fernandez AP , Sanchez-Garcia A , Martinez-Murillo R , Binda C , Lopez-Munoz F , Gobec S , Marco-Contelle J
Ref : Acta Pharmaceutica Sinica B , 13 :2152 , 2023
Abstract : Knez_2023_Acta.Pharmaceutica.Sinica.B_13_2152
ESTHER : Knez_2023_Acta.Pharmaceutica.Sinica.B_13_2152
PubMedSearch : Knez_2023_Acta.Pharmaceutica.Sinica.B_13_2152
PubMedID: 37250172
Gene_locus related to this paper: human-BCHE

Title : Discovery of new, highly potent and selective inhibitors of BuChE - Design, synthesis, in vitro and in vivo evaluation and crystallography studies - Panek_2023_Eur.J.Med.Chem_249_115135
Author(s) : Panek D , Pasieka A , Latacz G , Zareba P , Szczech M , Godyn J , Chantegreil F , Nachon F , Brazzolotto X , Skrzypczak-Wiercioch A , Walczak M , Smolik M , Salat K , Hofner G , Wanner K , Wieckowska A , Malawska B
Ref : Eur Journal of Medicinal Chemistry , 249 :115135 , 2023
Abstract : Panek_2023_Eur.J.Med.Chem_249_115135
ESTHER : Panek_2023_Eur.J.Med.Chem_249_115135
PubMedSearch : Panek_2023_Eur.J.Med.Chem_249_115135
PubMedID: 36696766
Gene_locus related to this paper: human-BCHE

Title : Grid-type Quaternary Metallosupramolecular Compounds Inhibit Human Cholinesterases through Dynamic Multivalent Interactions - Nachon_2022_Chembiochem_23_e202200456
Author(s) : Nachon F , Brazzolotto X , Dias J , Courageux C , Drozdz W , Cao XY , Stefankiewicz AR , Lehn JM
Ref : Chembiochem , 23 :e202200456 , 2022
Abstract : Nachon_2022_Chembiochem_23_e202200456
ESTHER : Nachon_2022_Chembiochem_23_e202200456
PubMedSearch : Nachon_2022_Chembiochem_23_e202200456
PubMedID: 36193860
Gene_locus related to this paper: human-BCHE

Title : From tryptophan-based amides to tertiary amines: Optimization of a butyrylcholinesterase inhibitor series - Meden_2022_Eur.J.Med.Chem_230_114248
Author(s) : Meden A , Knez D , Brazzolotto X , Nachon F , Dias J , Svete J , Stojan J , Groselj U , Gobec S
Ref : Eur Journal of Medicinal Chemistry , 230 :114248 , 2022
Abstract : Meden_2022_Eur.J.Med.Chem_230_114248
ESTHER : Meden_2022_Eur.J.Med.Chem_230_114248
PubMedSearch : Meden_2022_Eur.J.Med.Chem_230_114248
PubMedID: 35299116
Gene_locus related to this paper: human-BCHE

Title : Pseudo-irreversible butyrylcholinesterase inhibitors: Structure-activity relationships, computational and crystallographic study of the N-dialkyl O-arylcarbamate warhead - Meden_2022_Eur.J.Med.Chem_247_115048
Author(s) : Meden A , Knez D , Brazzolotto X , Modeste F , Perdih A , Pislar A , Zorman M , Zorovic M , Denic M , Pajk S , Zivin M , Nachon F , Gobec S
Ref : Eur Journal of Medicinal Chemistry , 247 :115048 , 2022
Abstract : Meden_2022_Eur.J.Med.Chem_247_115048
ESTHER : Meden_2022_Eur.J.Med.Chem_247_115048
PubMedSearch : Meden_2022_Eur.J.Med.Chem_247_115048
PubMedID: 36586299
Gene_locus related to this paper: human-BCHE

Title : Pseudo-irreversible butyrylcholinesterase inhibitors: SAR, kinetic, computational, and crystallographic study of the N-dialkyl O-arylcarbamate warhead - Meden_2022_Chemrxiv__
Author(s) : Meden A , Knez D , Brazzolotto X , Modeste F , Perdih A , Pislar A , Zorman M , Denic M , Pajk S , Nachon F , Gobec S
Ref : Chemrxiv , : , 2022
Abstract : Meden_2022_Chemrxiv__
ESTHER : Meden_2022_Chemrxiv__
PubMedSearch : Meden_2022_Chemrxiv__
PubMedID:
Gene_locus related to this paper: human-BCHE

Title : Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HT6R antagonists with beta-amyloid anti-aggregation properties - Wichur_2021_Eur.J.Med.Chem_225_113792
Author(s) : Wichur T , Godyn J , Goral I , Latacz G , Bucki A , Siwek A , Gluch-Lutwin M , Mordyl B , Sniecikowska J , Walczak M , Knez D , Jukic M , Salat K , Gobec S , Kolaczkowski M , Malawska B , Brazzolotto X , Wieckowska A
Ref : Eur Journal of Medicinal Chemistry , 225 :113792 , 2021
Abstract : Wichur_2021_Eur.J.Med.Chem_225_113792
ESTHER : Wichur_2021_Eur.J.Med.Chem_225_113792
PubMedSearch : Wichur_2021_Eur.J.Med.Chem_225_113792
PubMedID: 34530376
Gene_locus related to this paper: human-BCHE

Title : Fine-Tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidants for Neurodegenerative Diseases - Chavarria_2021_Antioxidants.(Basel)_10_329
Author(s) : Chavarria D , Da Silva O , Benfeito S , Barreiro S , Garrido J , Cagide F , Soares P , Remiao F , Brazzolotto X , Nachon F , Oliveira PJ , Dias J , Borges F
Ref : Antioxidants (Basel) , 10 :329 , 2021
Abstract : Chavarria_2021_Antioxidants.(Basel)_10_329
ESTHER : Chavarria_2021_Antioxidants.(Basel)_10_329
PubMedSearch : Chavarria_2021_Antioxidants.(Basel)_10_329
PubMedID: 33672269
Gene_locus related to this paper: human-ACHE , human-BCHE

Title : Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease - Rossi_2021_J.Med.Chem_64_4972
Author(s) : Rossi M , Freschi M , de Camargo Nascente L , Salerno A , de Melo Viana Teixeira S , Nachon F , Chantegreil F , Soukup O , Prchal L , Malaguti M , Bergamini C , Bartolini M , Angeloni C , Hrelia S , Soares Romeiro LA , Bolognesi ML
Ref : Journal of Medicinal Chemistry , 64 :4972 , 2021
Abstract : Rossi_2021_J.Med.Chem_64_4972
ESTHER : Rossi_2021_J.Med.Chem_64_4972
PubMedSearch : Rossi_2021_J.Med.Chem_64_4972
PubMedID: 33829779
Gene_locus related to this paper: human-BCHE

Title : Structure-activity relationship study of tryptophan-based butyrylcholinesterase inhibitors - Meden_2020_Eur.J.Med.Chem_208_112766
Author(s) : Meden A , Knez D , Malikowska-Racia N , Brazzolotto X , Nachon F , Svete J , Salat K , Groselj U , Gobec S
Ref : Eur Journal of Medicinal Chemistry , 208 :112766 , 2020
Abstract : Meden_2020_Eur.J.Med.Chem_208_112766
ESTHER : Meden_2020_Eur.J.Med.Chem_208_112766
PubMedSearch : Meden_2020_Eur.J.Med.Chem_208_112766
PubMedID: 32919297
Gene_locus related to this paper: human-BCHE

Title : N-alkylpiperidine carbamates as potential anti-Alzheimer's agents - Kosak_2020_Eur.J.Med.Chem_197_112282
Author(s) : Kosak U , Strasek N , Knez N , Jukic M , Zakelj S , Zahirovic A , Pislar A , Brazzolotto X , Nachon F , Kos J , Gobec S , Knez D
Ref : Eur Journal of Medicinal Chemistry , 197 :112282 , 2020
Abstract : Kosak_2020_Eur.J.Med.Chem_197_112282
ESTHER : Kosak_2020_Eur.J.Med.Chem_197_112282
PubMedSearch : Kosak_2020_Eur.J.Med.Chem_197_112282
PubMedID: 32380361
Gene_locus related to this paper: human-BCHE

Title : Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes - Pajk_2020_J.Enzyme.Inhib.Med.Chem_35_498
Author(s) : Pajk S , Knez D , Kosak U , Zorovic M , Brazzolotto X , Coquelle N , Nachon F , Colletier JP , Zivin M , Stojan J , Gobec S
Ref : J Enzyme Inhib Med Chem , 35 :498 , 2020
Abstract : Pajk_2020_J.Enzyme.Inhib.Med.Chem_35_498
ESTHER : Pajk_2020_J.Enzyme.Inhib.Med.Chem_35_498
PubMedSearch : Pajk_2020_J.Enzyme.Inhib.Med.Chem_35_498
PubMedID: 31914836
Gene_locus related to this paper: human-BCHE

Title : Enantioseparation, in vitro testing, and structural characterization of triple-binding reactivators of organophosphate-inhibited cholinesterases - Marakovic_2020_Biochem.J_477_2771
Author(s) : Marakovic N , Knezevic A , Roncevic I , Brazzolotto X , Kovarik Z , Sinko G
Ref : Biochemical Journal , 477 :2771 , 2020
Abstract : Marakovic_2020_Biochem.J_477_2771
ESTHER : Marakovic_2020_Biochem.J_477_2771
PubMedSearch : Marakovic_2020_Biochem.J_477_2771
PubMedID: 32639532
Gene_locus related to this paper: human-BCHE

Title : Rivastigmine and metabolite analogues with putative Alzheimer's disease-modifying properties in a Caenorhabditis elegans model. - Dighe_2019_Commun.Chem_2_35
Author(s) : Dighe SN , De la Mora E , Chan S , Kantham S , McColl G , Miles JA , Veliyath SK , Sreenivas BY , Nassar ZD , Silman I , Sussman JL , Weik M , McGeary RP , Parat MO , Brazzolotto X , Ross BP
Ref : Communications chemistry , 2 :35 , 2019
Abstract : Dighe_2019_Commun.Chem_2_35
ESTHER : Dighe_2019_Commun.Chem_2_35
PubMedSearch : Dighe_2019_Commun.Chem_2_35
PubMedID:
Gene_locus related to this paper: human-BCHE , torca-ACHE

Title : Tryptophan-derived butyrylcholinesterase inhibitors as promising leads against Alzheimer's disease - Meden_2019_Chem.Commun.(Camb)_55_3765
Author(s) : Meden A , Knez D , Jukic M , Brazzolotto X , Grsic M , Pislar A , Zahirovic A , Kos J , Nachon F , Svete J , Gobec S , Groselj U
Ref : Chem Commun (Camb) , 55 :3765 , 2019
Abstract : Meden_2019_Chem.Commun.(Camb)_55_3765
ESTHER : Meden_2019_Chem.Commun.(Camb)_55_3765
PubMedSearch : Meden_2019_Chem.Commun.(Camb)_55_3765
PubMedID: 30864579
Gene_locus related to this paper: human-BCHE

Title : Cryo-EM structure of the native butyrylcholinesterase tetramer reveals a dimer of dimers stabilized by a superhelical assembly - Leung_2018_Proc.Natl.Acad.Sci.U.S.A_115_13270
Author(s) : Leung MR , van Bezouwen LS , Schopfer LM , Sussman JL , Silman I , Lockridge O , Zeev-Ben-Mordehai T
Ref : Proc Natl Acad Sci U S A , 115 :13270 , 2018
Abstract : Leung_2018_Proc.Natl.Acad.Sci.U.S.A_115_13270
ESTHER : Leung_2018_Proc.Natl.Acad.Sci.U.S.A_115_13270
PubMedSearch : Leung_2018_Proc.Natl.Acad.Sci.U.S.A_115_13270
PubMedID: 30538207
Gene_locus related to this paper: human-BCHE

Title : Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities - Knez_2018_Eur.J.Med.Chem_156_598
Author(s) : Knez D , Coquelle N , Pislar A , Zakelj S , Jukic M , Sova M , Mravljak J , Nachon F , Brazzolotto X , Kos J , Colletier JP , Gobec S
Ref : Eur Journal of Medicinal Chemistry , 156 :598 , 2018
Abstract : Knez_2018_Eur.J.Med.Chem_156_598
ESTHER : Knez_2018_Eur.J.Med.Chem_156_598
PubMedSearch : Knez_2018_Eur.J.Med.Chem_156_598
PubMedID: 30031971
Gene_locus related to this paper: human-BCHE

Title : The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity - Kosak_2018_J.Med.Chem_61_119
Author(s) : Kosak U , Brus B , Knez D , Zakelj S , Trontelj J , Pislar A , Sink R , Jukic M , Zivin M , Podkowa A , Nachon F , Brazzolotto X , Stojan J , Kos J , Coquelle N , Salat K , Colletier JP , Gobec S
Ref : Journal of Medicinal Chemistry , 61 :119 , 2018
Abstract : Kosak_2018_J.Med.Chem_61_119
ESTHER : Kosak_2018_J.Med.Chem_61_119
PubMedSearch : Kosak_2018_J.Med.Chem_61_119
PubMedID: 29227101
Gene_locus related to this paper: human-BCHE

Title : Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study - Rosenberry_2017_Molecules_22_
Author(s) : Rosenberry TL , Brazzolotto X , Macdonald IR , Wandhammer M , Trovaslet-Leroy M , Darvesh S , Nachon F
Ref : Molecules , 22 : , 2017
Abstract : Rosenberry_2017_Molecules_22_
ESTHER : Rosenberry_2017_Molecules_22_
PubMedSearch : Rosenberry_2017_Molecules_22_
PubMedID: 29186056
Gene_locus related to this paper: human-BCHE

Title : N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents - Kosak_2017_Bioorg.Med.Chem_25_633
Author(s) : Kosak U , Knez D , Coquelle N , Brus B , Pislar A , Nachon F , Brazzolotto X , Kos J , Colletier JP , Gobec S
Ref : Bioorganic & Medicinal Chemistry , 25 :633 , 2017
Abstract : Kosak_2017_Bioorg.Med.Chem_25_633
ESTHER : Kosak_2017_Bioorg.Med.Chem_25_633
PubMedSearch : Kosak_2017_Bioorg.Med.Chem_25_633
PubMedID: 27908752
Gene_locus related to this paper: human-BCHE

Title : Bacterial Expression of Human Butyrylcholinesterase as a Tool for Nerve Agent Bioscavengers Development - Brazzolotto_2017_Molecules_22_
Author(s) : Brazzolotto X , Igert A , Guillon V , Santoni G , Nachon F
Ref : Molecules , 22 : , 2017
Abstract : Brazzolotto_2017_Molecules_22_
ESTHER : Brazzolotto_2017_Molecules_22_
PubMedSearch : Brazzolotto_2017_Molecules_22_
PubMedID: 29077024
Gene_locus related to this paper: human-BCHE

Title : The C5 Variant of the Butyrylcholinesterase Tetramer Includes a Noncovalently Bound 60 kDa Lamellipodin Fragment - Schopfer_2017_Molecules_22_
Author(s) : Schopfer LM , Delacour H , Masson P , Leroy J , Krejci E , Lockridge O
Ref : Molecules , 22 : , 2017
Abstract : Schopfer_2017_Molecules_22_
ESTHER : Schopfer_2017_Molecules_22_
PubMedSearch : Schopfer_2017_Molecules_22_
PubMedID: 28661448
Gene_locus related to this paper: human-BCHE

Title : Development of an in-vivo active reversible butyrylcholinesterase inhibitor - Kosak_2016_Sci.Rep_6_39495
Author(s) : Kosak U , Brus B , Knez D , Sink R , Zakelj S , Trontelj J , Pislar A , Slenc J , Gobec M , Zivin M , Tratnjek L , Perse M , Salat K , Podkowa A , Filipek B , Nachon F , Brazzolotto X , Wieckowska A , Malawska B , Stojan J , Rascan IM , Kos J , Coquelle N , Colletier JP , Gobec S
Ref : Sci Rep , 6 :39495 , 2016
Abstract : Kosak_2016_Sci.Rep_6_39495
ESTHER : Kosak_2016_Sci.Rep_6_39495
PubMedSearch : Kosak_2016_Sci.Rep_6_39495
PubMedID: 28000737
Gene_locus related to this paper: human-BCHE

Title : Discovery and Structure-Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening - Dighe_2016_J.Med.Chem_59_7683
Author(s) : Dighe SN , Deora GS , De la Mora E , Nachon F , Chan S , Parat MO , Brazzolotto X , Ross BP
Ref : Journal of Medicinal Chemistry , 59 :7683 , 2016
Abstract : Dighe_2016_J.Med.Chem_59_7683
ESTHER : Dighe_2016_J.Med.Chem_59_7683
PubMedSearch : Dighe_2016_J.Med.Chem_59_7683
PubMedID: 27405689
Gene_locus related to this paper: human-BCHE

Title : Kinetic characterization of a cocaine hydrolase engineered from mouse butyrylcholinesterase - Chen_2015_Biochem.J_466_243
Author(s) : Chen X , Huang X , Geng L , Xue L , Hou S , Zheng X , Brimijoin S , Zheng F , Zhan CG
Ref : Biochemical Journal , 466 :243 , 2015
Abstract : Chen_2015_Biochem.J_466_243
ESTHER : Chen_2015_Biochem.J_466_243
PubMedSearch : Chen_2015_Biochem.J_466_243
PubMedID: 25486543
Gene_locus related to this paper: human-BCHE

Title : Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents - Knez_2015_Bioorg.Med.Chem_23_4442
Author(s) : Knez D , Brus B , Coquelle N , Sosic I , Sink R , Brazzolotto X , Mravljak J , Colletier JP , Gobec S
Ref : Bioorganic & Medicinal Chemistry , 23 :4442 , 2015
Abstract : Knez_2015_Bioorg.Med.Chem_23_4442
ESTHER : Knez_2015_Bioorg.Med.Chem_23_4442
PubMedSearch : Knez_2015_Bioorg.Med.Chem_23_4442
PubMedID: 26116179
Gene_locus related to this paper: human-BCHE

Title : A highly efficient cocaine-detoxifying enzyme obtained by computational design - Zheng_2014_Nat.Commun_5_3457
Author(s) : Zheng F , Xue L , Hou S , Liu J , Zhan M , Yang W , Zhan CG
Ref : Nat Commun , 5 :3457 , 2014
Abstract : Zheng_2014_Nat.Commun_5_3457
ESTHER : Zheng_2014_Nat.Commun_5_3457
PubMedSearch : Zheng_2014_Nat.Commun_5_3457
PubMedID: 24643289
Gene_locus related to this paper: human-BCHE

Title : Amino-acid mutations to extend the biological half-life of a therapeutically valuable mutant of human butyrylcholinesterase - Fang_2014_Chem.Biol.Interact_214C_18
Author(s) : Fang L , Hou S , Xue L , Zheng F , Zhan CG
Ref : Chemico-Biological Interactions , 214C :18 , 2014
Abstract : Fang_2014_Chem.Biol.Interact_214C_18
ESTHER : Fang_2014_Chem.Biol.Interact_214C_18
PubMedSearch : Fang_2014_Chem.Biol.Interact_214C_18
PubMedID: 24582612
Gene_locus related to this paper: human-BCHE

Title : Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor - Brus_2014_J.Med.Chem_57_8167
Author(s) : Brus B , Kosak U , Turk S , Pislar A , Coquelle N , Kos J , Stojan J , Colletier JP , Gobec S
Ref : Journal of Medicinal Chemistry , 57 :8167 , 2014
Abstract : Brus_2014_J.Med.Chem_57_8167
ESTHER : Brus_2014_J.Med.Chem_57_8167
PubMedSearch : Brus_2014_J.Med.Chem_57_8167
PubMedID: 25226236
Gene_locus related to this paper: human-BCHE

Title : Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase - Nachon_2013_Biochem.J_453_393
Author(s) : Nachon F , Carletti E , Ronco C , Trovaslet M , Nicolet Y , Jean L , Renard PY
Ref : Biochemical Journal , 453 :393 , 2013
Abstract : Nachon_2013_Biochem.J_453_393
ESTHER : Nachon_2013_Biochem.J_453_393
PubMedSearch : Nachon_2013_Biochem.J_453_393
PubMedID: 23679855
Gene_locus related to this paper: human-ACHE , human-BCHE

Title : Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry - Carletti_2013_Chem.Res.Toxicol_26_280
Author(s) : Carletti E , Colletier JP , Schopfer LM , Santoni G , Masson P , Lockridge O , Nachon F , Weik M
Ref : Chemical Research in Toxicology , 26 :280 , 2013
Abstract : Carletti_2013_Chem.Res.Toxicol_26_280
ESTHER : Carletti_2013_Chem.Res.Toxicol_26_280
PubMedSearch : Carletti_2013_Chem.Res.Toxicol_26_280
PubMedID: 23339663
Gene_locus related to this paper: human-BCHE , mouse-ACHE

Title : A step toward the reactivation of aged cholinesterases - Crystal structure of ligands binding to aged human butyrylcholinesterase - Wandhammer_2013_Chem.Biol.Interact_203_19
Author(s) : Wandhammer M , De Koning MC , van Grol M , Loiodice M , Saurel L , Noort D , Goeldner M , Nachon F
Ref : Chemico-Biological Interactions , 203 :19 , 2013
Abstract : Wandhammer_2013_Chem.Biol.Interact_203_19
ESTHER : Wandhammer_2013_Chem.Biol.Interact_203_19
PubMedSearch : Wandhammer_2013_Chem.Biol.Interact_203_19
PubMedID: 22922115
Gene_locus related to this paper: human-BCHE

Title : Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure - Brazzolotto_2012_Febs.J_279_2905
Author(s) : Brazzolotto X , Wandhammer M , Ronco C , Trovaslet M , Jean L , Lockridge O , Renard PY , Nachon F
Ref : Febs J , 279 :2905 , 2012
Abstract : Brazzolotto_2012_Febs.J_279_2905
ESTHER : Brazzolotto_2012_Febs.J_279_2905
PubMedSearch : Brazzolotto_2012_Febs.J_279_2905
PubMedID: 22726956
Gene_locus related to this paper: human-BCHE

Title : X-ray crystallographic snapshots of reaction intermediates in the G117H mutant of human butyrylcholinesterase, a nerve agent target engineered into a catalytic bioscavenger - Nachon_2011_Biochem.J_434_73
Author(s) : Nachon F , Carletti E , Wandhammer M , Nicolet Y , Schopfer LM , Masson P , Lockridge O
Ref : Biochemical Journal , 434 :73 , 2011
Abstract : Nachon_2011_Biochem.J_434_73
ESTHER : Nachon_2011_Biochem.J_434_73
PubMedSearch : Nachon_2011_Biochem.J_434_73
PubMedID: 21091433
Gene_locus related to this paper: human-BCHE

Title : Reaction of cresyl saligenin phosphate, the organophosphorus agent implicated in aerotoxic syndrome, with human cholinesterases: mechanistic studies employing kinetics, mass spectrometry, and X-ray structure analysis - Carletti_2011_Chem.Res.Toxicol_24_797
Author(s) : Carletti E , Schopfer LM , Colletier JP , Froment MT , Nachon F , Weik M , Lockridge O , Masson P
Ref : Chemical Research in Toxicology , 24 :797 , 2011
Abstract : Carletti_2011_Chem.Res.Toxicol_24_797
ESTHER : Carletti_2011_Chem.Res.Toxicol_24_797
PubMedSearch : Carletti_2011_Chem.Res.Toxicol_24_797
PubMedID: 21438623
Gene_locus related to this paper: human-BCHE

Title : Structural study of the complex stereoselectivity of human butyrylcholinesterase for the neurotoxic V-agents - Wandhammer_2011_J.Biol.Chem_286_16783
Author(s) : Wandhammer M , Carletti E , van der Schans M , Gillon E , Nicolet Y , Masson P , Goeldner M , Noort D , Nachon F
Ref : Journal of Biological Chemistry , 286 :16783 , 2011
Abstract : Wandhammer_2011_J.Biol.Chem_286_16783
ESTHER : Wandhammer_2011_J.Biol.Chem_286_16783
PubMedSearch : Wandhammer_2011_J.Biol.Chem_286_16783
PubMedID: 21454498
Gene_locus related to this paper: human-BCHE

Title : Cocrystallization studies of full-length recombinant butyrylcholinesterase (BChE) with cocaine - Asojo_2011_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_67_434
Author(s) : Asojo OA , Ngamelue MN , Homma K , Lockridge O
Ref : Acta Crystallographica Sect F Struct Biol Cryst Commun , 67 :434 , 2011
Abstract : Asojo_2011_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_67_434
ESTHER : Asojo_2011_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_67_434
PubMedSearch : Asojo_2011_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_67_434
PubMedID: 21505234
Gene_locus related to this paper: human-BCHE

Title : Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun. - Carletti_2009_Biochem.J_421_97
Author(s) : Carletti E , Aurbek N , Gillon E , Loiodice M , Nicolet Y , Fontecilla-Camps JC , Masson P , Thiermann H , Nachon F , Worek F
Ref : Biochemical Journal , 421 :97 , 2009
Abstract : Carletti_2009_Biochem.J_421_97
ESTHER : Carletti_2009_Biochem.J_421_97
PubMedSearch : Carletti_2009_Biochem.J_421_97
PubMedID: 19368529
Gene_locus related to this paper: human-BCHE

Title : Aging of cholinesterases phosphylated by tabun proceeds through O-dealkylation - Carletti_2008_J.Am.Chem.Soc_130_16011
Author(s) : Carletti E , Li H , Li B , Ekstrom F , Nicolet Y , Loiodice M , Gillon E , Froment MT , Lockridge O , Schopfer LM , Masson P , Nachon F
Ref : Journal of the American Chemical Society , 130 :16011 , 2008
Abstract : Carletti_2008_J.Am.Chem.Soc_130_16011
ESTHER : Carletti_2008_J.Am.Chem.Soc_130_16011
PubMedSearch : Carletti_2008_J.Am.Chem.Soc_130_16011
PubMedID: 18975951
Gene_locus related to this paper: human-BCHE , mouse-ACHE

Title : Crystallization and X-ray structure of full-length recombinant human butyrylcholinesterase - Ngamelue_2007_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_63_723
Author(s) : Ngamelue MN , Homma K , Lockridge O , Asojo OA
Ref : Acta Crystallographica Sect F Struct Biol Cryst Commun , 63 :723 , 2007
Abstract : Ngamelue_2007_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_63_723
ESTHER : Ngamelue_2007_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_63_723
PubMedSearch : Ngamelue_2007_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_63_723
PubMedID: 17768338
Gene_locus related to this paper: human-BCHE

Title : Mechanisms of cholinesterase inhibition by inorganic mercury - Frasco_2007_FEBS.J_274_1849
Author(s) : Frasco MF , Colletier JP , Weik M , Carvalho F , Guilhermino L , Stojan J , Fournier D
Ref : Febs J , 274 :1849 , 2007
Abstract : Frasco_2007_FEBS.J_274_1849
ESTHER : Frasco_2007_FEBS.J_274_1849
PubMedSearch : Frasco_2007_FEBS.J_274_1849
PubMedID: 17355286
Gene_locus related to this paper: human-BCHE

Title : Naturally occurring mutation Leu307Pro of human butyrylcholinesterase in the Vysya community of India - Manoharan_2006_Pharmacogenet.Genomics_16_461
Author(s) : Manoharan I , Wieseler S , Layer PG , Lockridge O , Boopathy R
Ref : Pharmacogenet Genomics , 16 :461 , 2006
Abstract : Manoharan_2006_Pharmacogenet.Genomics_16_461
ESTHER : Manoharan_2006_Pharmacogenet.Genomics_16_461
PubMedSearch : Manoharan_2006_Pharmacogenet.Genomics_16_461
PubMedID: 16788378
Gene_locus related to this paper: human-BCHE

Title : The DNA sequence, annotation and analysis of human chromosome 3 - Muzny_2006_Nature_440_1194
Author(s) : Muzny DM , Scherer SE , Kaul R , Wang J , Yu J , Sudbrak R , Buhay CJ , Chen R , Cree A , Ding Y , Dugan-Rocha S , Gill R , Gunaratne P , Harris RA , Hawes AC , Hernandez J , Hodgson AV , Hume J , Jackson A , Khan ZM , Kovar-Smith C , Lewis LR , Lozado RJ , Metzker ML , Milosavljevic A , Miner GR , Morgan MB , Nazareth LV , Scott G , Sodergren E , Song XZ , Steffen D , Wei S , Wheeler DA , Wright MW , Worley KC , Yuan Y , Zhang Z , Adams CQ , Ansari-Lari MA , Ayele M , Brown MJ , Chen G , Chen Z , Clendenning J , Clerc-Blankenburg KP , Davis C , Delgado O , Dinh HH , Dong W , Draper H , Ernst S , Fu G , Gonzalez-Garay ML , Garcia DK , Gillett W , Gu J , Hao B , Haugen E , Havlak P , He X , Hennig S , Hu S , Huang W , Jackson LR , Jacob LS , Kelly SH , Kube M , Levy R , Li Z , Liu B , Liu J , Liu W , Lu J , Maheshwari M , Nguyen BV , Okwuonu GO , Palmeiri A , Pasternak S , Perez LM , Phelps KA , Plopper FJ , Qiang B , Raymond C , Rodriguez R , Saenphimmachak C , Santibanez J , Shen H , Shen Y , Subramanian S , Tabor PE , Verduzco D , Waldron L , Wang Q , Williams GA , Wong GK , Yao Z , Zhang J , Zhang X , Zhao G , Zhou J , Zhou Y , Nelson D , Lehrach H , Reinhardt R , Naylor SL , Yang H , Olson M , Weinstock G , Gibbs RA
Ref : Nature , 440 :1194 , 2006
Abstract : Muzny_2006_Nature_440_1194
ESTHER : Muzny_2006_Nature_440_1194
PubMedSearch : Muzny_2006_Nature_440_1194
PubMedID: 16641997
Gene_locus related to this paper: human-AADAC , human-AADACL2 , human-ABHD5 , human-ABHD6 , human-ABHD10 , human-ABHD14A , human-APEH , human-BCHE , human-CIB , human-LIPH , human-MGLL , human-NLGN1 , human-PLA1A

Title : Role of water in aging of human butyrylcholinesterase inhibited by echothiophate: the crystal structure suggests two alternative mechanisms of aging - Nachon_2005_Biochemistry_44_1154
Author(s) : Nachon F , Asojo OA , Borgstahl GE , Masson P , Lockridge O
Ref : Biochemistry , 44 :1154 , 2005
Abstract : Nachon_2005_Biochemistry_44_1154
ESTHER : Nachon_2005_Biochemistry_44_1154
PubMedSearch : Nachon_2005_Biochemistry_44_1154
PubMedID: 15667209
Gene_locus related to this paper: human-BCHE

Title : Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products - Nicolet_2003_J.Biol.Chem_278_41141
Author(s) : Nicolet Y , Lockridge O , Masson P , Fontecilla-Camps JC , Nachon F
Ref : Journal of Biological Chemistry , 278 :41141 , 2003
Abstract : Nicolet_2003_J.Biol.Chem_278_41141
ESTHER : Nicolet_2003_J.Biol.Chem_278_41141
PubMedSearch : Nicolet_2003_J.Biol.Chem_278_41141
PubMedID: 12869558
Gene_locus related to this paper: human-BCHE

Title : Cocaine metabolism accelerated by a re-engineered human butyrylcholinesterase - Sun_2002_J.Pharmacol.Exp.Ther_302_710
Author(s) : Sun H , Shen ML , Pang YP , Lockridge O , Brimijoin S
Ref : Journal of Pharmacology & Experimental Therapeutics , 302 :710 , 2002
Abstract : Sun_2002_J.Pharmacol.Exp.Ther_302_710
ESTHER : Sun_2002_J.Pharmacol.Exp.Ther_302_710
PubMedSearch : Sun_2002_J.Pharmacol.Exp.Ther_302_710
PubMedID: 12130735
Gene_locus related to this paper: human-BCHE

Title : Re-engineering butyrylcholinesterase as a cocaine hydrolase - Sun_2002_Mol.Pharmacol_62_220
Author(s) : Sun H , Pang YP , Lockridge O , Brimijoin S
Ref : Molecular Pharmacology , 62 :220 , 2002
Abstract : Sun_2002_Mol.Pharmacol_62_220
ESTHER : Sun_2002_Mol.Pharmacol_62_220
PubMedSearch : Sun_2002_Mol.Pharmacol_62_220
PubMedID: 12130672
Gene_locus related to this paper: human-BCHE

Title : Effects of mutations of active site residues and amino acids interacting with the Omega loop on substrate activation of butyrylcholinesterase - Masson_2001_Biochim.Biophys.Acta_1544_166
Author(s) : Masson P , Xie W , Froment MT , Lockridge O
Ref : Biochimica & Biophysica Acta , 1544 :166 , 2001
Abstract : Masson_2001_Biochim.Biophys.Acta_1544_166
ESTHER : Masson_2001_Biochim.Biophys.Acta_1544_166
PubMedSearch : Masson_2001_Biochim.Biophys.Acta_1544_166
PubMedID: 11341926
Gene_locus related to this paper: human-BCHE

Title : The sequence of the human genome - Venter_2001_Science_291_1304
Author(s) : Venter JC , Adams MD , Myers EW , Li PW , Mural RJ , Sutton GG , Smith HO , Yandell M , Evans CA , Holt RA , Gocayne JD , Amanatides P , Ballew RM , Huson DH , Wortman JR , Zhang Q , Kodira CD , Zheng XH , Chen L , Skupski M , Subramanian G , Thomas PD , Zhang J , Gabor Miklos GL , Nelson C , Broder S , Clark AG , Nadeau J , McKusick VA , Zinder N , Levine AJ , Roberts RJ , Simon M , Slayman C , Hunkapiller M , Bolanos R , Delcher A , Dew I , Fasulo D , Flanigan M , Florea L , Halpern A , Hannenhalli S , Kravitz S , Levy S , Mobarry C , Reinert K , Remington K , Abu-Threideh J , Beasley E , Biddick K , Bonazzi V , Brandon R , Cargill M , Chandramouliswaran I , Charlab R , Chaturvedi K , Deng Z , Di Francesco V , Dunn P , Eilbeck K , Evangelista C , Gabrielian AE , Gan W , Ge W , Gong F , Gu Z , Guan P , Heiman TJ , Higgins ME , Ji RR , Ke Z , Ketchum KA , Lai Z , Lei Y , Li Z , Li J , Liang Y , Lin X , Lu F , Merkulov GV , Milshina N , Moore HM , Naik AK , Narayan VA , Neelam B , Nusskern D , Rusch DB , Salzberg S , Shao W , Shue B , Sun J , Wang Z , Wang A , Wang X , Wang J , Wei M , Wides R , Xiao C , Yan C , Yao A , Ye J , Zhan M , Zhang W , Zhang H , Zhao Q , Zheng L , Zhong F , Zhong W , Zhu S , Zhao S , Gilbert D , Baumhueter S , Spier G , Carter C , Cravchik A , Woodage T , Ali F , An H , Awe A , Baldwin D , Baden H , Barnstead M , Barrow I , Beeson K , Busam D , Carver A , Center A , Cheng ML , Curry L , Danaher S , Davenport L , Desilets R , Dietz S , Dodson K , Doup L , Ferriera S , Garg N , Gluecksmann A , Hart B , Haynes J , Haynes C , Heiner C , Hladun S , Hostin D , Houck J , Howland T , Ibegwam C , Johnson J , Kalush F , Kline L , Koduru S , Love A , Mann F , May D , McCawley S , McIntosh T , McMullen I , Moy M , Moy L , Murphy B , Nelson K , Pfannkoch C , Pratts E , Puri V , Qureshi H , Reardon M , Rodriguez R , Rogers YH , Romblad D , Ruhfel B , Scott R , Sitter C , Smallwood M , Stewart E , Strong R , Suh E , Thomas R , Tint NN , Tse S , Vech C , Wang G , Wetter J , Williams S , Williams M , Windsor S , Winn-Deen E , Wolfe K , Zaveri J , Zaveri K , Abril JF , Guigo R , Campbell MJ , Sjolander KV , Karlak B , Kejariwal A , Mi H , Lazareva B , Hatton T , Narechania A , Diemer K , Muruganujan A , Guo N , Sato S , Bafna V , Istrail S , Lippert R , Schwartz R , Walenz B , Yooseph S , Allen D , Basu A , Baxendale J , Blick L , Caminha M , Carnes-Stine J , Caulk P , Chiang YH , Coyne M , Dahlke C , Mays A , Dombroski M , Donnelly M , Ely D , Esparham S , Fosler C , Gire H , Glanowski S , Glasser K , Glodek A , Gorokhov M , Graham K , Gropman B , Harris M , Heil J , Henderson S , Hoover J , Jennings D , Jordan C , Jordan J , Kasha J , Kagan L , Kraft C , Levitsky A , Lewis M , Liu X , Lopez J , Ma D , Majoros W , McDaniel J , Murphy S , Newman M , Nguyen T , Nguyen N , Nodell M , Pan S , Peck J , Peterson M , Rowe W , Sanders R , Scott J , Simpson M , Smith T , Sprague A , Stockwell T , Turner R , Venter E , Wang M , Wen M , Wu D , Wu M , Xia A , Zandieh A , Zhu X
Ref : Science , 291 :1304 , 2001
Abstract : Venter_2001_Science_291_1304
ESTHER : Venter_2001_Science_291_1304
PubMedSearch : Venter_2001_Science_291_1304
PubMedID: 11181995
Gene_locus related to this paper: human-AADAC , human-ABHD1 , human-ABHD10 , human-ABHD11 , human-ACHE , human-BCHE , human-LDAH , human-ABHD18 , human-CMBL , human-ABHD17A , human-KANSL3 , human-LIPA , human-LYPLAL1 , human-NDRG2 , human-NLGN3 , human-NLGN4X , human-NLGN4Y , human-PAFAH2 , human-PREPL , human-RBBP9 , human-SPG21

Title : Butyrylcholinesterase genes in individuals with abnormal inhibition numbers and with trace activity: one common mutation and two novel silent genes - Dey_1998_Ann.Clin.Biochem_35_302
Author(s) : Dey DC , Maekawa M , Sudo K , Kanno T
Ref : Annals of Clinical Biochemistry , 35 :302 , 1998
Abstract : Dey_1998_Ann.Clin.Biochem_35_302
ESTHER : Dey_1998_Ann.Clin.Biochem_35_302
PubMedSearch : Dey_1998_Ann.Clin.Biochem_35_302
PubMedID: 9547905
Gene_locus related to this paper: human-BCHE

Title : Organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase: synergy results in a somanase - Millard_1998_Biochemistry_37_237
Author(s) : Millard CB , Lockridge O , Broomfield CA
Ref : Biochemistry , 37 :237 , 1998
Abstract : Millard_1998_Biochemistry_37_237
ESTHER : Millard_1998_Biochemistry_37_237
PubMedSearch : Millard_1998_Biochemistry_37_237
PubMedID: 9425044
Gene_locus related to this paper: human-BCHE

Title : Human butyrylcholinesterase L330I mutation belongs to a fluoride-resistant gene, by expression in human fetal kidney cells - Sudo_1997_Biochem.Biophys.Res.Commun_240_372
Author(s) : Sudo K , Maekawa M , Akizuki S , Magara T , Ogasawara H , Tanaka T
Ref : Biochemical & Biophysical Research Communications , 240 :372 , 1997
Abstract : Sudo_1997_Biochem.Biophys.Res.Commun_240_372
ESTHER : Sudo_1997_Biochem.Biophys.Res.Commun_240_372
PubMedSearch : Sudo_1997_Biochem.Biophys.Res.Commun_240_372
PubMedID: 9388484
Gene_locus related to this paper: human-BCHE

Title : Overlapping drug interaction sites of human butyrylcholinesterase dissected by site-directed mutagenesis - Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423
Author(s) : Loewenstein-Lichtenstein Y , Glick D , Gluzman N , Sternfeld M , Zakut H , Soreq H
Ref : Molecular Pharmacology , 50 :1423 , 1996
Abstract : Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423
ESTHER : Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423
PubMedSearch : Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423
PubMedID: 8967962
Gene_locus related to this paper: human-BCHE

Title : Prolonged response to succinylcholine: a new variant of plasma cholinesterase that is identified as normal by traditional phenotyping methods -
Author(s) : Greenberg CP , Primo-Parmo SL , Pantuck EJ , La Du BN
Ref : Anesthesia & Analgesia , 81 :419 , 1995
PubMedID: 7618741
Gene_locus related to this paper: human-BCHE

Title : Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket - Ordentlich_1993_J.Biol.Chem_268_17083
Author(s) : Ordentlich A , Barak D , Kronman C , Flashner Y , Leitner M , Segall Y , Ariel N , Cohen S , Velan B , Shafferman A
Ref : Journal of Biological Chemistry , 268 :17083 , 1993
Abstract : Ordentlich_1993_J.Biol.Chem_268_17083
ESTHER : Ordentlich_1993_J.Biol.Chem_268_17083
PubMedSearch : Ordentlich_1993_J.Biol.Chem_268_17083
PubMedID: 8349597
Gene_locus related to this paper: human-ACHE , human-BCHE

Title : Genetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholine. - Lockridge_1990_Pharmacol.Ther_47_35
Author(s) : Lockridge O
Ref : Pharmacol Ther , 47 :35 , 1990
Abstract : Lockridge_1990_Pharmacol.Ther_47_35
ESTHER : Lockridge_1990_Pharmacol.Ther_47_35
PubMedSearch : Lockridge_1990_Pharmacol.Ther_47_35
PubMedID: 2195556
Gene_locus related to this paper: human-BCHE

Title : Aspartate-70 to glycine substitution confers resistance to naturally occurring and synthetic anionic-site ligands on in-ovo produced human butyrylcholinesterase - Neville_1990_J.Neurosci.Res_27_452
Author(s) : Neville LF , Gnatt A , Loewenstein Y , Soreq H
Ref : Journal of Neuroscience Research , 27 :452 , 1990
Abstract : Neville_1990_J.Neurosci.Res_27_452
ESTHER : Neville_1990_J.Neurosci.Res_27_452
PubMedSearch : Neville_1990_J.Neurosci.Res_27_452
PubMedID: 2079709
Gene_locus related to this paper: human-BCHE

Title : Structure of human serum cholinesterase. -
Author(s) : Lockridge O
Ref : Bioessays , 9 :125 , 1988
PubMedID: 3067729
Gene_locus related to this paper: human-BCHE

Title : Brain cDNA clone for human cholinesterase - McTiernan_1987_Proc.Natl.Acad.Sci.U.S.A_84_6682
Author(s) : McTiernan C , Adkins S , Chatonnet A , Vaughan TA , Bartels CF , Kott M , Rosenberry TL , La Du BN , Lockridge O
Ref : Proceedings of the National Academy of Sciences of the United States of America , 84 :6682 , 1987
Abstract : McTiernan_1987_Proc.Natl.Acad.Sci.U.S.A_84_6682
ESTHER : McTiernan_1987_Proc.Natl.Acad.Sci.U.S.A_84_6682
PubMedSearch : McTiernan_1987_Proc.Natl.Acad.Sci.U.S.A_84_6682
PubMedID: 3477799
Gene_locus related to this paper: human-BCHE

Title : Isolation and characterization of full-length cDNA clones coding for cholinesterase from fetal human tissues - Prody_1987_Proc.Natl.Acad.Sci.U.S.A_84_3555
Author(s) : Prody CA , Zevin-Sonkin D , Gnatt A , Goldberg O , Soreq H
Ref : Proceedings of the National Academy of Sciences of the United States of America , 84 :3555 , 1987
Abstract : Prody_1987_Proc.Natl.Acad.Sci.U.S.A_84_3555
ESTHER : Prody_1987_Proc.Natl.Acad.Sci.U.S.A_84_3555
PubMedSearch : Prody_1987_Proc.Natl.Acad.Sci.U.S.A_84_3555
PubMedID: 3035536
Gene_locus related to this paper: human-BCHE

Title : Complete amino acid sequence of human serum cholinesterase - Lockridge_1987_J.Biol.Chem_262_549
Author(s) : Lockridge O , Bartels CF , Vaughan TA , Wong CK , Norton SE , Johnson LL
Ref : Journal of Biological Chemistry , 262 :549 , 1987
Abstract : Lockridge_1987_J.Biol.Chem_262_549
ESTHER : Lockridge_1987_J.Biol.Chem_262_549
PubMedSearch : Lockridge_1987_J.Biol.Chem_262_549
PubMedID: 3542989
Gene_locus related to this paper: human-BCHE