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Family Report for: Carb_B_Chordata

Carb_B_Chordata



Relationship
Block C
Parent Family : Carboxylesterase

Comment
This family was extracted from the previous Carboxylesterase COesterase family. This family corresponds to the Carbohydrate Esterase family CE10 in CAZy - Carbohydrate-Active enZYmes database (CE_10). Mammalian liver carboxylesterases (CESs; EC 3.1.1.1) hydrolyze various xenobiotics and endogenous substrates with ester, thioester, or amide bonds and are thought to function mainly in drug metabolism and detoxication of harmful chemicals. CES1 is also responsible for hydrolysis of stored cholesterol esters in macrophage foam cells and release of free cholesterol for high density lipoprotein-mediated cholesterol efflux
1 Risk(s) factors

1 Xenobiotic(s) sensitivity
CES-1 deficiency in gene_locus human-CES1 with OMIM 114835.


Database
Sequences
Interpro
|
IPR002018 (Carboxylesterase, type B)
PIRSF
|
Pdoc
|
PFam
|
PF00135 (COesterase)
Prints
|
Prosite
|
EC at KEGG
|
EC at EXPASY
|


Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
11 more
    Title: Carboxylesterases in lipid metabolism: from mouse to human
    Lian J, Nelson R, Lehner R
    Ref: Protein Cell, 9:178, 2018 : PubMed

            

    Title: Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins
    Holmes RS, Wright MW, Laulederkind SJ, Cox LA, Hosokawa M, Imai T, Ishibashi S, Lehner R, Miyazaki M and Maltais LJ <9 more author(s)>
    Ref: Mamm Genome, 21:427, 2010 : PubMed

            

    Title: Genomic analysis of the carboxylesterases: identification and classification of novel forms
    Williams ET, Wang H, Wrighton SA, Qian YW, Perkins EJ
    Ref: Mol Phylogenet Evol, 57:23, 2010 : PubMed

            

Other Papers


Structure scheme for Carb_B_Chordata

Structures in Carb_B_Chordata family (20)

Genes Proteins in Carb_B_Chordata family (543)

Fragments of genes in Carb_B_Chordata family (295)

Substrates of some enzymes in the Carb_B_Chordata family (95)

Inhibitors of some enzymes in the Carb_B_Chordata family (42)



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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